Journal of Clinical Oncology
Articles in this Issue
Patient-reported outcomes from the adjuvant ado-trastuzumab emtansine (T-DM1) for older patients with HER2+ breast cancer (ATOP) trial.
635 Background: Prospective data on efficacy, quality of life, and treatment-related toxicities in older adults with breas...
Effect of ripretinib on the pharmacokinetics (PK) of midazolam (MDZ), a sensitive CYP3A probe substrate, in adult patients (pts) with advanced gastrointestinal stromal tumor (GIST).
e23509 Background: Ripretinib is a switch-control tyrosine kinase inhibitor (TKI) indicated for the treatment of adult pts...
Real-world treatment patterns and overall survival (OS) in patients (pts) with HER2-positive (HER2+) advanced or metastatic gastroesophageal adenocarcinomas (mGEA) in the US.
4053 Background: The first-line (1L) standard of care for pts with HER2+ mGEA is HER2-targeted therapy (HER2 Tx) plus plat...
Pirtobrutinib in treatment-naïve patients with CLL/SLL: Pooled results from BRUIN CLL-313 and BRUIN CLL-314.
7044 Background: Pirtobrutinib, a highly selective, non-covalent Bruton tyrosine kinase inhibitor (BTKi), is approved glob...
The efficacy and safety of add-on ruxolitinib for patients with severe checkpoint inhibitor pneumonitis management with corticosteroids: A multicenter, open-label, randomised phase 2 trial.
12016 Background: Checkpoint inhibitor pneumonitis (CIP) stands out as a remarkable complication during ICIs therapy. Seve...
Association of proton pump inhibitor use with cancer-specific mortality in a nationally representative U.S. cohort (NHANES, 1999–2018).
10625 Background: Proton pump inhibitors (PPIs) are widely used and often continued beyond recommended durations. Evidence...
Predictors of EGFR-mutant primary lung adenocarcinoma.
10591 Background: The proportion of lung cancer cases in individuals who have never smoked (INS) is increasing. Most of th...
Inpatient outcomes by socioeconomic characteristics among younger adults hospitalized with gastrointestinal malignancies in the United States, 2018–2022.
e23168 Background: Early-onset gastrointestinal (GI) cancers are increasingly recognized, yet national data describing inp...
Association of acute myeloid leukemia (AML) patient, disease, and molecular characteristics with a long-term (LT) response to olutasidenib.
6523 Background: Mutations in isocitrate dehydrogenase 1 (m IDH1 ) occur in 7%-14%...
Comparative risk of osteopenia, osteoporosis, and pathological fractures in breast cancer patients treated with steroidal versus non-steroidal aromatase inhibitors: A large-scale real-world data analysis.
e12683 Background: Aromatase inhibitors (AIs) are widely used in hormone positive breast cancer. They are classified as ei...
Real-world outcomes of atezolizumab versus durvalumab in extensive-stage small cell lung cancer.
e23393 Background: Advent landmark trials, IMpower133 and CASPIAN, demonstrated improved median progression-free survival...
Disparities in statin prescription for secondary prevention of atherosclerotic cardiovascular disease in a Midwestern lung cancer screening population.
e13723 Background: Heart issues are a leading cause of death among lung cancer patients. Statins can effectively reduce pa...
A phase 1, first-in-human study of DS5361, a small-molecule, nonsense-mediated mRNA decay (NMD) inhibitor in patients with advanced/metastatic solid tumors (parts 1 and 2).
TPS2680 Background: Despite the profound impact of immune checkpoint inhibitors (ICIs) on the treatment of patients with a...
A global phase 1/2a trial of SHR-A1904, a CLDN18.2-targeting ADC, in advanced solid tumors expressing CLDN18.2.
e15018 Background: SHR-A1904, a novel CLDN18.2 targeted ADC, showed promising antitumor activity in pretreated CLDN18.2-po...
Integrated proteogenomic profiling to reveal prognostic subtypes and actionable targets in adenoid cystic carcinoma.
6067 Background: Adenoid cystic carcinoma (ACC) is a rare head and neck malignancy characterized by highly variable clinic...
Genetic signatures of CNS relapse in DLBCL patients profiled with next-generation sequencing (NGS).
7016 Background: CNS relapse of DLBCL is a devastating event with median survival <6 months. While the overall incidenc...
Clinicopathologic features of South African colorectal cancer patients by HIV status in a retrospective cohort study.
3658 Background: Colorectal cancer (CRC) is increasing among people living with HIV. South Africa (SA) has the largest HIV...
Targeting MAT2A-mediated metabolic pathways: A novel strategy for non-small cell lung cancer therapy.
e20711 Background: Methionine adenosyltransferase 2A (MAT2A) links metabolic reprogramming with epigenetic regulation by p...
Cardiotoxicity and mortality trends in chemotherapy-treated breast cancer patients before and during the COVID-19 pandemic.
e24013 Background: The Coronavirus Disease 2019 (COVID-19) pandemic caused widespread disruptions in breast cancer screeni...
Registry-based machine learning in Sezary syndrome: Assessment of prognostic signal and age-masked racial inequities.
e22615 Background: Sézary syndrome (SS) is a rare leukemic cutaneous T-cell lymphoma with limited contemporary population...
Impact of COVID-19 mRNA vaccines on survival outcomes in patients with solid tumors receiving immunotherapy: A large-scale retrospective study.
2637 Background: Immune checkpoint inhibitors (ICIs) became the cornerstone in the treatment of solid tumors. While person...
Phase II single-arm trial of low-dose capecitabine in patients with advanced breast cancer.
TPS1159 Background: Capecitabine is approved for use in both the adjuvant and metastatic settings of breast cancer. The cl...
A network analysis of symptoms in women with metastatic breast cancer undergoing systemic therapy.
e13107 Background: Women with metastatic breast cancer (MBC) experience various concurrent symptoms during cancer treatmen...
Updated efficacy results from the phase I cervical cancer cohort of BAT8008, a TROP-2–directed antibody-drug conjugate, in patients with advanced cervical cancer.
5507 Background: BAT8008 is a novel antibody-drug conjugate comprising a TROP-2 antibody and an exatecan payload. Patients...
A pillar of safety: Standardizing oral chemotherapy protocols.
e23323 Background: Standardizing protocols for oral chemotherapy treatment and delivery is a critical quality improvement...