Journal of Clinical Oncology
Articles in this Issue
CURE AI as a predictor of TIGIT as a therapeutic target in pediatric cancers.
e22000 Background: Clinical trials are not able to study individual treatment effects as methods to do so have not...
Integrated clinical and genomic analysis of mediastinal germ cell tumors (GCT) with somatic transformation (SM): A multi-institutional cohort study.
5029 Background: SM of GCT is a rare but lethal entity largely described in the context of testicular primaries. The disti...
Incorporating tumor pathological subtype into a multiparameter model: Improved accuracy in predicting prostate cancer extraprostatic extension.
e17117 Background: Extraprostatic extension (EPE) at radical prostatectomy (RP) is associated with worse biochemical recur...
Immune checkpoint blockade (ICB) in advanced/metastatic leiomyosarcoma (LMS): Real-world cohort from MD Anderson.
e23545 Background: LMS is an aggressive soft-tissue sarcoma with an immunologically “cold” tumor microenvironment and hist...
Septicemia in acute lymphoblastic leukemia: Disparities in incidence, resource utilization, and mortality between pediatric and adult populations.
e18510 Background: Acute lymphoblastic leukemia (ALL) in adults has substantially worse outcomes than pediatric ALL, with...
Demographic patterns and survival outcomes in acute myeloid leukemia with t(6;9)(p23;q34); DEK–NUP214.
e18553 Background: Acute myeloid leukemia (AML) with t(6;9)(p23;q34); DEK–NUP214 is a rare, adverse-risk cytogenetic subty...
Development and early implementation of a statewide comprehensive childhood cancer network to support pediatric oncology care and research.
10056 Background: Although pediatric cancer survival has improved substantially, families continue to face fragmented acce...
Competing risks of relapse and major organ failure after allogeneic hematopoietic cell transplantation.
e18579 Background: Outcomes after allogeneic hematopoietic cell transplantation (allo-HCT) are often summarized using over...
Prognostic validation of artificial intelligence (AI)–based Stratipath breast risk stratification in TAILORx.
555 Background: Stratipath Breast is an AI-based prognostic medical device for risk stratification of early-stage breast c...
Hearing/vestibular dysfunction and longitudinal changes in psychosocial well-being among breast cancer survivors.
12084 Background: Breast cancer treatment, in some cases, can cause hearing/vestibular dysfunction and negatively affect p...
Efficacy and safety of giredestrant (GIRE) in patients (pts) with estrogen receptor–positive, HER2-negative early breast cancer (ER+, HER2– eBC) in the phase III lidERA BC clinical trial: Results by menopausal status.
502 Background: The lidERA BC trial (NCT04961996) demonstrated a statistically significant, clinically meaningful improvem...
Characteristics of patients with resectable early-stage non–small cell lung cancer treated with neoadjuvant chemoimmunotherapy or surgery ± adjuvant therapy.
8061 Background: The integration of immune checkpoint inhibitors (ICIs) into neoadjuvant, perioperative, and adjuvant trea...
Long-term cognitive impairment after CAR-T therapy compared with autologous stem cell transplantation.
7032 Background: Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of relapsed and refractor...
Establishing a rapid diagnostic clinic at a tertiary care cancer center: The Indiana University Simon Comprehensive Cancer Center (IUSCCC) experience.
e13602 Background: Rapid diagnostic clinics (RDCs) are designed to accelerate evaluation and treatment for patients with s...
Analysis of an oral anticancer repository program and the impact on access to care.
1506 Background: Patients with cancer face many barriers to timely access of oral anticancer agents, including financial t...
Preliminary clinical validation of a novel integrated genomic and epigenomic liquid biopsy assay (SPIRAL) in breast cancer.
e22511 Background: Early detection of breast cancer is critical for improving patient outcomes. Liquid biopsy using circul...
Cachexia index, allostatic load, and body composition phenotypes in racially and ethnically diverse patients with metastatic colorectal cancer.
e15601 Background: Cachexia Index (CXI), which integrates muscle mass, nutritional status, and systemic inflammation, and...
FGFR-targeted therapies in advanced esophagogastric cancer: A systematic review and meta-analysis.
e16053 Background: Esophagogastric cancer carries high mortality, with most patients diagnosed at advanced stages. In HER2...
A phase II exploratory study of iparomlimab and tuvonralimab (QL1706) combined with bevacizumab in patients with locally advanced or metastatic MSI-H/dMMR colorectal cancer.
TPS3677 Background: Microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) colorectal cancer (CRC) is high...
Towards hyper-sensitive MRD: Assessment of Enspyre as a cost-effective ctDNA detection technique using very large variant panels.
e15048 Background: Tumor-informed minimal residual disease (MRD) assays track patient-specific variants at significantly h...
Incidence of new keratinocyte cancers during pembrolizumab in resectable cutaneous squamous cell carcinoma: The De-Squamate study.
9582 Background: Patients with advanced cutaneous squamous cell carcinoma (cSCC) or basal cell carcinoma (BCC) frequently...
A real-world comparison of treatment and survival outcomes with zanubrutinib (zanu) and acalabrutinib (acala) monotherapy among patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL) in the United States.
7062 Background: MCL is a rare and aggressive subtype of B-cell non-Hodgkin lymphoma that remains incurable. Bruton tyrosi...
Outcomes and responsiveness of standard tyrosine kinase inhibitor dose versus dose de-escalation in chronic myeloid leukemia: A single-center retrospective study.
6598 Background: Treatment with tyrosine kinase inhibitors (TKIs) enables patients with chronic myeloid leukemia (CML) to...
Comparative analysis of the tumor microenvironment in primary versus metastatic lymph node malignancies using The Cancer Genome Atlas data.
e15189 Background: The tumor microenvironment (TME) plays a critical role in cancer progression, immune evasion, and metas...
Trends in soft tissue sarcoma of the heart in the United States (1975–2022): A SEER-based analysis.
e23571 Background: Soft tissue sarcoma of the heart is an extremely rare malignancy with limited population-level data. Ev...