Journal of Clinical Oncology
Articles in this Issue
Elacestrant in combination with capivasertib in patients with ER+/HER2− advanced breast cancer: Update from ELEVATE, a phase 1b/2, open-label, umbrella study.
1098 Background: Disease progression in patients (pts) with ER+/HER2- ABC on 1L ET+CDK4/6i is associated with several mech...
Short-term financial toxicity in CAR T-cell therapy.
e23264 Background: While chimeric antigen receptor T-cell therapy (CAR-T) is remarkably efficacious in achieving remission...
Which treatment is best? A systematic review and Bayesian network meta-analysis of adjuvant treatments for low-grade glioma.
2057 Background: The standard of care for low-grade glioma (LGG) includes resection with or without adjuvant treatment. It...
Emergency presentation as a diagnostic failure phenotype in ovarian cancer: A National Inpatient analysis (NIS 2016–2023).
e17575 Background: Ovarian cancer is generally diagnosed and managed through outpatient care pathways, yet a substantial p...
Intersecting rural, racial, and Medicaid disparities in cervical cancer outcomes across North Carolina, 2019–2023.
1523 Background: Although national cervical cancer incidence has declined, mortality disparities persist, particularly amo...
Clinicopathologic features and prognosis of breast cancer in germline <i>ATM</i> and <i>CHEK2</i> carriers: A monocentric retrospective study.
e22625 Background: Germline pathogenic or likely pathogenic variants (PV/LPVs) in moderate-risk genes like...
Impact of adult failure to thrive (AFTT) on inpatient mortality (IM) and resource utilization in patients with gastrointestinal cancer (GIC): A nationwide analysis.
e15708 Background: AFTT is characterized by physical, nutritional, and psychosocial decline. In GIC, AFTT arises from maln...
Platinum-sensitive relapsed SCLC: What is the best option? A meta-analysis.
e20155 Background: Small cell lung cancer (SCLC) remains highly aggressive with high relapse rates despite platinum-based...
Burden of disease management among patients with multiple myeloma and their care partners.
e23253 Background: The complexity of current multiple myeloma (MM) treatment (tx) regimens imposes burdens on daily life,...
Germline analysis in Latino young adults with early-onset cancer.
e22639 Background: An estimated 5-10% of cancers are inherited, and 35% carry a variant of unknown significance (VUS). We...
Delivering oncology care in Syria: Implementation lessons from conflict-affected and resource-limited settings.
1607 Background: Oncology services are often excluded from humanitarian health response packages despite the rising cancer...
Disparities in initial systemic staging imaging workup for endometrial cancer.
e17614 Background: Endometrial cancer (EC) is the sixth most common cancer in females, with rising incidence. CT chest (CT...
Expressive writing for body image distress and anxiety in adolescent and young adult cancer survivors: A pilot, randomized controlled trial.
12082 Background: Up to 60% of adolescent and young adult cancer survivors (ages 15-39) experience body image distress but...
Safety and efficacy of Azer-cel, an allogeneic CD19 CAR T for the treatment of patients with relapsed/refractory non-Hodgkin lymphoma and chronic lymphocytic leukemia not previously exposed to autologous CAR T therapy.
7012 Background: Azer-cel (azercabtagene zapreleucel) is an allogeneic, off-the-shelf, CD19-directed, chimeric antigen rec...
Utilization of artificial intelligence (AI) scribes (AIS) by the hematology and oncology (HemOnc) workforce: Characterizing adoption patterns, barriers, and clinical gaps.
e13677 Background: The development of AI led to the emergence of tools such as AIS, which have been increasingly adopted i...
Real-world outcomes of immunotherapy in older adults with advanced NSCLC: A retrospective cohort analysis.
e20587 Background: Immunotherapy is a standard first-line treatment for driver gene-negative advanced non-small cell lung...
Impact of social determinants of health on women with early-onset colorectal cancer: A retrospective study.
3662 Background: The incidence of early-onset colorectal cancer (EOCRC) in adults under age 50 has significantly increased...
MC240701: Decentralized pilot study of triple oral metronomic chemotherapy in recurrent/metastatic oral cavity cancer.
TPS6126 Background: Oral cavity cancers (OCC) are a rare subtype of head and neck cancer (HNC) with poor outcomes and limi...
Evaluation of intraperitoneal dehydration, hyperthermia, and chemotherapy in an in vitro model of peritoneal metastasis.
e15200 Background: A newly introduced combination of intraperitoneal dehydration, hyperthermia, and subsequent chemotherap...
Current landscape and future directions of breast cancer screening and early detection of disease: A literature review and experts’ perspective.
e22553 Background: Breast cancer (BC) is the second leading cause of cancer-related deaths among women in the US. Advances...
Second primary malignancies after CAR-T versus SCT in multiple myeloma.
e19556 Background: Multiple myeloma (MM) survival has improved with autologous stem cell transplantation (SCT) and immunot...
Chromosomal instability and integrated tumor-margin immune ecosystem remodeling as drivers of progression of pulmonary ground-glass nodules.
8027 Background: Precise management of pulmonary ground-glass nodules (GGNs) is hindered by an incomplete understanding of...
Exploring the clinical significance of pathogenic variants in Lynch syndrome: A single-center retrospective review.
e22657 Background: Lynch syndrome (LS) is the most common hereditary cancer syndrome and is associated with increased mali...
Phase 2 study of PFS in third-line immune checkpoint inhibitor–resistant advanced NSCLC treated with the telomere-targeting agent ateganosine (THIO; 6-thio-2'-deoxyguanosine) sequenced with ICI.
e20610 Background: Despite advancements in third line treatments, long-term survival for advanced non-small cell lung canc...
National trends and disparities in gallbladder cancer mortality in the United States, 1999–2023.
e16286 Background: Gallbladder cancer (GBC) is a rare but devastating gastrointestinal malignancy with an incidence of 122...