Journal of Clinical Oncology
Articles in this Issue
Adjuvant cisplatin regimens for locoregionally advanced head and neck squamous cell carcinoma: A meta-analysis.
e18121 Background: The optimal postoperative cisplatin dosing schedule for locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN) re...
Clinical characteristics and treatment outcomes of hepatosplenic T-cell lymphoma: Mayo Clinic experience.
7075 Background: Hepatosplenic T-cell lymphoma (HSTCL) is a rare, aggressive peripheral T-cell lymphoma arising primarily from γδ T-cells. It carries a po...
Comparison of mobile mammography versus urban hospital-based breast cancer screening.
1605 Background: Breast cancer screening via mobile mammography units (MMU) is used to improve access in medically underserved communities. This study aim...
Transoral robotic surgery (TORS) and de-escalated adjuvant therapy for human papillomavirus-related oropharyngeal carcinoma (HPVOPC): Long-term follow up of the Sinai Robotic Surgery (SIRS) trial (NCT02072148).
6089 Background: De-escalation therapy for HPVOPC remains undefined and controversial. Definitive and postoperative chemoradiation are associated with sig...
Accuracy of MRI in the detection of pathological complete response post neoadjuvant therapy in locally advanced colorectal cancer.
e15670 Background: Pathological Complete Response (pCR) conventionally denotes the absence of malignant cells in rectal specimens resected from patients w...
Global trends in disability adjusted life years (DALYs) and mortality rates in gastric cancer among elderly (70+ Years) from 1990-2021: A Global Burden of Disease study.
e16133 Background: Although the incidence and mortality of gastric cancer have decreased over the past decades due to the progress in diagnostic methods,...
Clinicopathological and prognostic characteristics of gastric-type endocervical adenocarcinoma: A single-center retrospective study.
5525 Background: Gastric-type endocervical adenocarcinoma (G-EAC) is a rare and highly aggressive subtype of cervical cancer. Limited screening methods of...
Long-term follow-up of patterns of melanoma early and late recurrence after adjuvant anti-PD1 therapy.
e21527 Background: Despite the promise of immune checkpoint inhibitors (ICI), 25-30% of stage III/IV patients (pts) with (w) resected melanoma develop rel...
Technical performance of the L3 Skeletal Muscle Index in CT.
e24073 Background: Skeletal muscle, beyond mobility, is now seen as a vital endocrine organ with significant metabolic roles affecting overall health. Ass...
Phase I dose escalation and expansion study of PRAME T-cell receptor (TCR) engineered IL15-transduced cord blood–derived natural killer (NK) cells in patients with recurrent and/or refractory melanoma (PRAMETIME-Mel).
TPS9602 Background: For patients with relapsed and/or refractory metastatic melanoma (RRFM), there is a critical need to test novel strategies with improv...
Efficacy and safety of depatuxizumab mafodotin (ABT-414) in EGFR-amplified glioblastoma: A systematic review and Bayesian network meta-analysis.
2060 Background: Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, typically resulting in a median survival of 12–15 months. Ep...
Systematic review of BCMA-targeted therapies in relapsed/refractory (R/R) multiple myeloma (MM).
e19528 Background: MM patients still face unmet medical needs, especially in the R/R setting. Recent breakthroughs in B cell maturation antigen (BCMA)-tar...
Real-world outcomes of nivolumab plus ipilimumab versus immune checkpoint inhibitor and tyrosine kinase inhibitor combinations as first-line treatment for metastatic clear cell renal cell carcinoma.
e16510 Background: The management of metastatic clear cell renal cell carcinoma (mccRCC) has evolved significantly with the introduction of immune checkpo...
Impact of socioeconomic and demographic factors on treatment-related time intervals in oral cavity cancers: National Cancer Database study.
e18122 Background: Oral cavity squamous cell carcinoma (OCSCC) has high mortality, recurrence, and metastasis, requiring multimodal treatment. Treatment d...
Effect of pre-biopsy steroids on diagnostic yield in diffuse large B-cell lymphoma (DLBCL).
7072 Background: DLBCL is an aggressive lymphoma, and patients (pts) often require urgent steroid administration for symptom relief or organ compromise pr...
Knowledge and barriers to breast and cervical cancer screening in rural Nigerian communities: An ethnographic study.
e23233 Background: There is a growing need for health researchers, policymakers, and practitioners in resource-limited settings to leverage ethnography fo...
Real-time AI-based computer-aided detection/diagnosis (AI-CAD) for breast ultrasound: A prospective, multicenter, multinational study.
1569 Background: To evaluate the effectiveness of a real-time AI-based computer-aided detection/diagnosis (AI-CAD) system as a diagnostic decision support...
A novel non-invasive machine learning model for predicting tertiary lymphoid structures and treatment response to neoadjuvant therapy in triple-negative breast cancer: A multicenter retrospective study.
e13596 Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) and neoadjuvant therapy (NAT) has become an essenti...
DLBCL-associated PIM1 mutation and its impact on ANXA2 localization and lymphomagenesis.
7060 Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and has an overall cure rate of approximately 60...
Levels of immune responses in tertiary lymphoid structures of non-small cell lung cancer (NSCLC) and association with survival.
2627 Background: Tumor-infiltrating tertiary lymphoid structures (TLSs) are thought to have anti-tumor activity and are believed to indicate a favorable p...
Comparison of intraoperative ex-vivo electrical impedance measurements for oral squamous cell carcinoma.
e18100 Background: Oral squamous cell carcinoma (OSCC) is a prevalent, lethal cancer representing 4.6% of global cancer-related deaths. 60% of oral cancer...
Patterns and clinical significance of high-risk secondary cytogenetic abnormalities at first relapse in multiple myeloma.
e19545 Background: Cytogenetic abnormalities (CA) at diagnosis are important prognostic factors in multiple myeloma (MM), but there is limited information...
Triple-negative breast cancer remodeling of the tissue immune microenvironment by regulation of embryonic-derived tissue-resident macrophage polarization through the IRF7/CH25H/25HC pathway.
e14557 Background: The immune microenvironment of breast cancer is richly infiltrated with macrophages, yet modulation targeting macrophage polarization h...
Racial and ethnic disparities in clinical outcomes of HER2-positive metastatic breast cancer treated with antibody-drug conjugates: A TriNetX real-world evidence study.
1036 Background: HER2-positive breast cancer (HER2+ BC) is an aggressive BC subtype driven by overexpression of the human epidermal growth factor receptor...
Safety and efficacy of chimeric antigen receptor (CAR)–T cell therapy (BRG01) targeting the Epstein-Barr virus (EBV) envelope protein in EBV+ lymphoproliferative disease patients.
7079 Background: Epstein-Barr virus (EBV) is a type I carcinogen which has infected more than 95% of population. EBV infection is closely associated with...