Journal of Clinical Oncology
Articles in this Issue
Impact of autoimmune disease on toxicity and outcomes after idecabtagene vicleucel in patients with multiple myeloma.
7552 Background: Idecabtagene vicleucel (ide-cel), an autologous BCMA-directed chimeric antigen receptor (CAR) T-cell therapy, has the potential to cure p...
Alcohol use and liver cancer mortality in the U.S. (1999–2020): A CDC WONDER analysis.
e13535 Background: Alcohol consumption is a major risk factor for liver cancer, contributing to preventable mortality. This study examines trends in U.S....
Multicenter trial of microbubble-enhanced transcranial focused ultrasound (MB-FUS) with monthly adjuvant temozolomide for patients with high-grade gliomas.
2009 Background: High-grade gliomas (HGGs) have few effective therapies targeting tumor cell recurrence, which remain shielded by blood-brain barrier (BBB...
Chemo-praidict eBC: A deep learning solution for predicting pathological complete response on biopsies of breast cancer patients treated with neoadjuvant chemotherapy.
e15156 Background: In precision medicine, the prediction of tumor chemosensitivity is of major importance to offer cancer patients the best possible treat...
Efficacy and safety of distamab vedotin combined with carboplatin and bevacizumab for HER2-expressing platinum-sensitive ovarian cancer with prior PARPi treatment.
e17580 Background: Disitamab Vedotin (DV) is a newly developed antibody-drug conjugate targeting human epidermal growth factor 2 (HER2) that is comprised...
Effect of oral mucositis on nutrition among patients with head and neck cancer.
e18123 Background: Cancer encompasses a vast array of diseases characterised by the uncontrolled division of abnormal cells that have the potential to inf...
Association of total neoadjuvant therapy sequencing with surgical intervention and overall survival in locally advanced rectal cancer: An NCDB analysis.
e15630 Background: Pooled analyses of the CAO/ARO/AIO-12 and OPRA trials in locally advanced rectal cancer (LARC) suggest that chemoradiotherapy followed...
First accounting of comprehensive radiotherapy life cycle assessment components in Africa.
e23213 Background: Climate change is a pressing issue on the global stage. Recently a comprehensive lifecycle assessment (LCA) of external beam radiothera...
Efficacy and safety of busulfan-fludarabine versus busulfan-cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplant in hematologic malignancy patients: A meta-analysis of randomized controlled trials and observational studies.
e18546 Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for hematologic malignancies but comes with risks...
Clear and non-clear cell renal cell carcinomas and the ability to engage in oxidative phosphorylation.
4542 Background: The impairment of oxidative phosphorylation (OxPhos) and upregulation of aerobic glycolysis, mediated by the loss of VHL...
Navigating healthcare costs and family support: Coping strategies adopted by breast cancer patients in a tertiary cancer care center—A qualitative phenomenological analysis.
e21022 Background: Economic distress caused by high costs of cancer treatment poses a significant challenge to patients and their caregivers. It affects t...
Outcomes with targeted therapy for NRAS-mutated melanoma: A systematic review and meta-analysis.
e21506 Background: Despite advancements in targeted therapy, NRAS-mutated melanoma remains a significant therapeutic challenge. This meta-analysis aims to...
Breast cancer survivors' perspectives on a clinical decision tool to facilitate individualized exercise prescriptions within clinical settings.
e13715 Background: Current clinical guidelines recommend that clinicians provide individualized exercise prescriptions to cancer survivors. However, there...
Radiotherapy integration strategy for small-cell lung cancer in extensive stage (RISE) with up to 10 metastases: A study protocol of a randomized phase II trial.
TPS8125 Background: The standard of care (SoC) for patients with extensive-disease small-cell lung cancer (ED-SCLC) currently involves chemo-immunotherapy...
Melanoma dormancy: Predictors of relapse in resected early-stage cutaneous melanoma.
e21557 Background: Early-stage (IA, IB, IIA) cutaneous melanoma (CM) is treated with wide local excision (WLE). However, some patients (PTS) relapse (R),...
Limited versus expanded multigene germline genetic testing among adolescents and young adults (AYA) with breast cancer.
10588 Background: In low- and middle-income countries, like ours, breast cancer is diagnosed mostly in younger women. With a median age of 50-52 years, br...
EORTC-2129-BCG: Elacestrant for treating ER+/HER2- breast cancer patients with ctDNA relapse (TREAT ctDNA).
TPS620 Background: (Neo)adjuvant systemic treatment, with chemotherapy and/or endocrine therapy (ET), substantially reduces the recurrence rates of estrog...
AI-driven risk stratification for disease progression after allo-SCT in AML.
e18562 Background: Disease progression is the leading cause of allogeneic stem cell transplantation (allo-SCT) failure in acute myeloid leukemia (AML). Ou...
Thymosin alpha-1–enhanced PRaG regimen: A novel approach to boosting immune dynamics and therapeutic efficacy in advanced solid tumors.
e14606 Background: Severe lymphopenia remains a significant obstacle to the long-term success of immunotherapy. In combination therapies, radiation-induce...
Clinical outcomes of patients with stage I triple-negative breast cancer (TNBC) treated with or without chemotherapy: The Mayo Clinic experience.
548 Background: TNBC is associated with higher risk of recurrence and poorer survival rates than other breast cancer subtypes. For node-positive TNBC or t...
Disparities in health-related quality of life between low-income Latino and white men with prostate cancer.
e23187 Background: Prostate cancer is the second most common cancer and the most diagnosed cancer among Latino men in the United States. Advances in scree...
Radiomic phenotypes of tumor angiogenesis compared with PD-L1 in pre-treatment prediction of outcomes across immunotherapy regimens in NSCLC: An external validation study.
8581 Background: Tumor angiogenesis is critical to cancer progression and treatment resistance, as evidenced by the success of therapies targeting both im...
Mutations in homologous recombination DNA damage repair genes and treatment outcomes to immune checkpoint inhibitors in melanomas.
e21502 Background: Homologous recombination DNA damage repair (HR-DDR) gene mutations are frequently found in melanomas, and studies have shown the presen...
Clinical characteristics and prognostic factors for survival in metastatic osteosarcoma, a 2004-2021 retrospective analysis of cases in SEER.
e23512 Background: Osteosarcoma is the most common primary bone malignancy, and 20% of cases are metastatic at diagnosis. Previous studies analyzing data...
Innovative data visualization tool for tracking system failures in colorectal cancer screening.
e13598 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the U.S., yet 30% of Americans are not up to date with...