Journal of Clinical Oncology
Articles in this Issue
Optimizing timeliness of first appointment with medical oncology: A quality improvement initiative at Northwell Health Cancer Institute.
e23248 Background: As part of the quality improvement initiative , the Northwell Health Cancer Institute aimed to improve the average time to first appoin...
Understanding and increasing awareness of social determinants of health of patients with cancer treated by the MD Anderson Oncology Program at Lyndon B Johnson Hospital.
e23237 Background: Harris Health serves nearly a quarter of Harris County, the third most populous county in the United States. As a safety-net healthcare...
Neoadjuvant PD-1 inhibitor combined with Nab-paclitaxel and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NCT05522985): A randomized, controlled, open label, phase II clinical trial.
6018 Background: More than 60% of head and neck squamous cell carcinoma (HNSCC) patients (pts) were locally advanced at diagnosis. Many previous clinical...
Parenting challenges of international medical graduate hematologists-oncologists in the United States.
9016 Background: Almost two-thirds of physicians report delaying childbearing due to medical training. Amongst hematologists-oncologists (HOs), up to 75%...
Computational pathology to predict docetaxel benefit for high-risk localized prostate cancer in NRG/RTOG 0521 (NCT00288080).
1557 Background: The benefit of adding docetaxel (DTX) to standard of care (SOC) for high-risk localized prostate cancer remains debated. The NRG/RTOG 052...
Clinical characteristics and outcomes of multiple myeloma in Asian Indian and Pakistani Americans (AIPA).
e19558 Background: Multiple myeloma (MM) is a hematologic malignancy associated with significant morbidity and mortality, including complications like ost...
Utilizing cancer community outreach and engagement to explain impact of age, income, residence, knowledge, and survivorship on cancer fatalism in urban and rural/marginalized areas.
10538 Background: Nigeria has the highest cancer burden in sub-Saharan Africa, with 124,815 incidences and 78,899 deaths. Popular fatalistic beliefs such...
Association of initial abemaciclib dosing with duration of medication use in patients with stage II/III breast cancer on endocrine therapy.
e12514 Background: The CDK 4/6 inhibitor abemaciclib is given to decrease risk of distant recurrence of breast cancer. However, its use has been limited b...
Symptom burden, quality of life (QoL), social and behavioral characteristics in young patients (<40 years old) with cancer: A prospective cohort of 7323 patients across 110 sites in France and Belgium.
1615 Background: Cancer in individuals under 40 years old is increasingly recognized as a public health concern, characterized by unique etiologies, biolo...
The efficacy of watch and wait strategy or surgery after neoadjuvant immunotherapy for locally advanced colorectal cancer with dMMR/MSI-H guided by ctDNA dynamic monitoring (WINDOW): A single-center, open-label, prospective, phase II study.
3559 Background: Circulating tumor DNA (ctDNA) has shown potential in predicting the efficacy of neoadjuvant treatment for colorectal cancer (CRC). Howeve...
Transforming data management in clinical trials: Uncovering CRC pain points through user research.
e21001 Background: Clinical trial timelines are significantly influenced by the efficiency of data transfer from sites’ Electronic Health Records (EHRs) t...
Phase 1 study results of JNJ-78278343 (pasritamig) in metastatic castration-resistant prostate cancer (mCRPC).
5017 Background: Human kallikrein 2 (encoded by the KLK2 gene and hereafter referred to as KLK2) is a novel target expressed on PC...
Exploring the impact of race, ethnicity, and BMI on neoadjuvant hormonal treatment outcomes.
e12590 Background: Neoadjuvant hormonal therapy (NHT) is a treatment option for estrogen receptor-positive (ER+) breast cancer (BC) in postmenopausal wome...
A pilot exercise program in breast cancer survivors: Group vs individual training outcomes.
12050 Background: Exercise interventions have consistently led to improved fitness in breast cancer patients. Best practices to ensure longevity of lifest...
Risk of non-breast cancer–related mortality in breast cancer and dependence on disease characteristics, treatment, and survival duration.
12041 Background: Breast Cancer (BC) has seen significant improvement in survival in both early (eBC) and metastatic (mBC) setting. Prolonged survival inc...
ScRNA-seq profiles to identify HES1 associated with ACTH-secreting tumors and the distinct microenvironment between ACTH+/CRH+ and ACTH-/CRH- pheochromocytomas.
e16604 Background: Ectopic ACTH and/or CRH-secreting pheochromocytomas are rare catecholamine-secreting tumors originating from adrenal medulla, which cou...
Trial in progress: A phase Ib/II study to evaluate the safety and efficacy of atezolizumab plus bevacizumab as adjuvant therapy following carbon ion radiotherapy in hepatocellular carcinoma (VANGUARD trial).
TPS4222 Background: While hepatic resection remains the standard curative treatment for hepatocellular carcinoma (HCC), many cases are ineligible due to i...
Unveiling the promising potential of luspatercept in transfusion-dependent lower-risk myelodysplastic syndromes: A systematic review and meta-analysis.
e18580 Background: Myelodysplastic syndromes (MDS) are characterized by ineffective blood cell production. Luspatercept (Reblozyl) is a recently approved...
Clinical effectiveness of urine DNA for minimal residual disease (MRD) monitoring of urothelial carcinoma in urine: A multicenter, prospective, observational study.
TPS4617 Background: Limited methods and poor compliance are major issues in urothelial carcinoma (UC) surveillance. Non-invasive monitoring of minimal res...
Evaluating efficacy of targeted microwave ablation in patients with prostate cancer: A systematic review and proportional meta-analysis.
e17133 Background: Prostate cancer (PC) remains one of the most prevalent malignancies affecting men worldwide. Targeted focal therapies have helped ablat...
Project Shirley: Fear of recurrence and risk communication in Australian HR+ HER2– early breast cancer patients.
e13867 Background: Fear of cancer recurrence (FCR) significantly affects survivors of hormone receptor-positive (HR+), HER2-negative early breast cancer (...
Clinicopathological features of colorectal cancer in adolescents and young adults (AYA) at a tertiary referral centre in Nigeria.
3629 Background: Colorectal cancer (CRC) is traditionally considered a disease of older adults; however, its incidence among AYA has been rising globally....
Multimodal AI using host, tumor, and ghost biomarker for predicting immunotherapy efficacy in NSCLC.
8578 Background: Almost all NSCLC patients (pts) without driver alterations received a first-line based immunotherapy (IO). It is unclear if pts with very...
A phase I trial of binimetinib plus hydroxychloroquine inpatients with previously treated metastatic pancreatic cancer.
4152 Background: Combined MEK and autophagy inhibition exerts synergistic antitumor activity in preclinical models of RAS-mutant cancers. We hypothesized...
Understanding patient preferences for supplemental methods of communication of new drug approvals in breast cancer survivors.
e13551 Background: The landscape of cancer care is evolving rapidly. In 2023, there were 83 new FDA oncology approvals, and 145 interventional treatment (...