Journal of Clinical Oncology
Articles in this Issue
Risk factors for high-grade prostate cancer in an inner-city population: Analysis of commonly dispensed medications and patient comorbidities.
e17080 Background: The purpose of this study was to determine risk factors for having high-grade prostate cancer at biopsy by analyzing commonly dispensed...
Real-world zanubrutinib treatment patterns in mantle cell lymphoma (MCL) among US community oncology patients with prior Bruton tyrosine kinase inhibitor (BTKi) therapy.
e23270 Background: MCL is a rare and aggressive type of non-Hodgkin lymphoma. The next-generation BTKi, zanubrutinib (zanu), was developed to maximize eff...
Effect of induction chemo-immunotherapy on the chance for re-irradiation in high-risk recurrent nasopharyngeal carcinoma: A prospective, single-arm, phase II trial.
6040 Background: The PRANCIS model has been shown to be robust for identifying patients with recurrent nasopharyngeal carcinoma (rNPC) who are at high ris...
Temporal patterns in renal cancer mortality: A 20-year analysis of US-Mexico border states.
e16534 Background: Kidney cancers pose a growing health challenge in the U.S., with rising incidence and mortality. Individuals in U.S.-Mexico border stat...
First-line treatment with surufatinib, camrelizumab, nab-paclitaxel, and S-1 in locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC): A phase Ib/II randomized study.
4161 Background: PDAC is a highly aggressive cancer with limited treatment options. Previous reports of NCT05218889 showed promising efficacy of nab-Pacli...
Predicting pathologic complete response in colorectal cancer patients after immunotherapy based on endoscopic biopsy and deep learning approach.
3532 Background: Immune checkpoint inhibitors (ICIs) have emerged as effective treatments for microsatellite instability-high (MSI-H)/deficient mismatch r...
Molecular landscape of distinct follicular lymphoma histologic grades: Insights from genomic and transcriptome analyses.
7002 Background: The 2022 World Health Organization Classification of Hematologic Malignancies classifies follicular lymphoma grad...
Immune landscape of sarcoma patients treated with an autologous dendritic cell vaccine.
e23530 Background: The role of the sarcoma immune tumor microenvironment (TME) is a critical area of ongoing research, particularly to understand response...
Return to intended oncologic therapy in patients with metastatic non-small cell lung cancer discharged to a skilled nursing facility.
e23062 Background: Hospitalized patients with metastatic non-small cell lung cancer (mNSCLC) with poor performance status are commonly discharged to a ski...
Pathomics-based prediction of thymic epithelial tumor subtypes within the French RYTHMIC network.
8112 Background: Thymic epithelial tumors (TETs) are classified into primary subtypes (A, AB, B1, B2, B3, C) and mixed classes, determined by varying prop...
Neo-adjuvant chemo-immunotherapy in pancreatic cancer: Results of the Australasian Gastrointestinal Trials Group (AGITG) NEO-IMPACT pilot trial.
4189 Background: Despite curative intent surgery and peri-operative chemotherapy for resectable pancreatic ductal adenocarcinoma (PDAC), recurrence rate r...
Investigation of tumor-associated macrophages (TAMs) and therapeutic resistance to immune checkpoint inhibitors (ICI) through single-cell analysis of renal cell carcinoma (RCC).
4527 Background: RCC is characterized by a tumor microenvironment (TME) enriched in TAMs, which suppress antitumor immunity in RCC. We conducted a compreh...
Bothersome hot flashes following relugolix and stereotactic body radiotherapy for localized prostate cancer.
e17087 Background: Androgen deprivation therapy (ADT) has been shown to improve cancer control when combined with radiation therapy. Relugolix is an oral...
Disparities in receipt of palliative interventions across disaggregated Hispanic subgroups with late-stage colon cancer in the United States.
12078 Background: Palliative interventions, defined as cancer-directed therapies with palliative intent, improve the quality of life and alleviate sufferi...
CDK inhibitors and radiation therapy in breast cancer: Hematologic toxicity and survival implications.
e15095 Background: Breast cancer is the most common cancer and the second leading cause of cancer-related deaths in women. Hormone receptor-positive, HER2...
Identification of germline hereditary cancer syndrome variants and associated cancers in a healthcare biobank population.
10581 Background: Identification of pathogenic/likely pathogenic variants (P/LPV) in hereditary cancer syndrome (HCS) genes enables surveillance and preve...
MRI-based radiomics for prediction of isocitrate dehydrogenase subtype in glioblastoma multiforme through artificial intelligence models: A systematic review and meta analysis.
2074 Background: Gliomas are aggressive tumours with poor prognosis. Isocitrate Dehydrogenase (IDH) mutations are present...
Patient preferences for survivorship educational programs.
e13870 Background: Patient feedback is instrumental in shaping the programs provided to a survivorship program. This valuable information allows us to mor...
Molecular profiling in targeted therapy of gliomas in a community setting.
e14030 Background: In the 2021 WHO Classification for gliomas, molecular characteristics are mandatory for classification. However, there is not enough da...
Bone marrow polyclonal plasma cells in myeloma post-treatment: Implications on outcome and effect of therapy.
e19531 Background: Effective treatment and elimination of clonal plasma cells (PC) in multiple myeloma (MM) are typically associated with recovery of poly...
Real-world efficacy of first-line chemotherapy plus nivolumab in gastric and GEJ adenocarcinoma patients: The ORACLE study.
e16087 Background: Nivolumab (NIV) plus chemotherapy (CHT) is the standard first-line treatment for advanced gastric and gastroesophageal junction (GEJ) a...
Impact of racial disparities on efficacy and safety outcomes for patients with RRMM receiving T-cell engagers.
e19523 Background: The approval of T-cell engagers (TCEs) for multiple myeloma (MM) has led to prolonged survival, yet baseline health disparities have be...
Impact of mutant STK11, KEAP1, and KRAS on firstline chemoimmunotherapy survival outcomes in metastatic non-small cell lung cancer (NSCLC): A meta-analysis of randomized and comparative studies.
e20504 Background: Frontline chemoimmunotherapy has emerged as a revolutionary treatment modality for advanced lung cancer, significantly altering the the...
Endotrophin: Analysis of a fibroinflammatory biomarker during breast cancer therapy.
e15056 Background: A major challenge in breast cancer research is identifying actionable biomarkers that enable the precise molecular characterization of...
Pan-cancer gene set discovery via scRNA-seq for optimal deep learning based downstream tasks.
e13606 Background: The application of deep learning to transcriptomics data has enabled various downstream tasks in cancer research. Due to the high dimen...