The Journal of Immunology
Articles in this Issue
Adaptor SLP-76 couples the TCR to glucose metabolism in T-cells with augmented obesity 2310033
Abstract Introduction The adaptor protein SLP-76 is indispensable for thymic T-cell development, yet its contribution to peripheral T-cell si...
Th10 and activated Tfh1 expansion correlate with strong, while Tfr expansion correlate with poor responses to Fluzone High Dose in older adults 2259592
Abstract Introduction Seasonal influenza poses a significant health risk to older adults (>65 years), who exhibit reduced vaccine effe...
Modeling Infection-Associated Chronic Illness: Murine Borrelia burgdorferi-Driven Connective Tissue Alterations and MAESTRO Clinical Correlates 2260529
Abstract Introduction Borrelia burgdorferi (Bb), the bacterium that causes Lyme disease, is linked to chronic illness in an estimated two mil...
Caspase-8 regulates cell death and inflammatory responses in complex respiratory infection 2259631
Abstract Introduction Lung infections represent a major global health burden, with pneumonia remaining one of the leading causes of death in...
Validated high throughput microneutralization assay for anti-AAV2 neutralizing antibodies (NAbs) in clinical trials in support of gene therapy 2247247
Abstract Introduction Recombinant adeno-associated (AAV) viral vectors are being widely used in gene therapy. One of the challenges for AAV-b...
Molecular characterization of the IgE serological repertoire in pediatric peanut allergy 2267488
Abstract Introduction Though recent strides in peanut allergy prevention have changed the clinical thinking about pediatric treatment, the an...
CD43 regulates T-cell function and survival in a context-dependent manner 2299796
Abstract Introduction CD43 (sialophorin) is a sialomucin widely expressed on hematopoietic cells that governs T-cell adhesion, trafficking, a...
GPR25 as a novel target to boost anti-tumor TRM responses 2300820
Abstract Introduction Tissue-resident memory CD8 T (TRM) cells are central to durable antiviral and antitumor immunity, yet the molecular cue...
CD8 T cells require IFNg to induce disease in a murine model of Alopecia Areata 2310132
Abstract Introduction Alopecia Areata (AA) is a prevalent autoimmune disease affecting 2% of the population and presents as nonscarring hair...
Simplifying CD19 CAR Detection: A Bright Single-Step Solution for Flow Cytometry 2259753
Abstract Introduction Accurate flow cytometric detection of CD19 CAR-expressing cells is critical across CAR-T cell discovery and translation...
IL2 signaling and Foxp1 expression maintain Treg identity in the absence of Foxp3 2260415
Abstract Introduction Regulatory T cells (Treg) have a pivotal role in tolerance and immune homeostasis. In autoimmunity, Treg are destabiliz...
Proinflammatory Genes are Transcriptionally Suppressed by Type I Interferon Through Undescribed Non-canonical Mechanisms 2259728
Abstract Introduction Type I interferons (IFN) are crucial for effective antiviral immune responses. Paradoxically, they exhibit poorly defin...
Critical role of 4-1BB:4-1BBL axis in humoral immune responses against Plasmodium 2242516
Abstract Introduction Several costimulatory and coinhibitory signaling axis have been reported to modulate anti-Plasmodium immune response, a...
Antibodies cloned from a patient with Idiopathic CD4 Lymphopenia induce potent anti-T and B cell complement-dependent lysis 2304145
Abstract Introduction Idiopathic CD4 Lymphopenia (ICL) is a rare immunodeficiency disorder characterized by an unexplained CD4+ T-cell lympho...
Creation of the first gluten allergenicity map using diploid, tetraploid, and hexaploid wheats in a mouse model 2300763
Abstract Introduction Gluten allergy is a growing global disease affecting individuals with high risk of potentially deadly anaphylactic reac...
Inhibition of Innate Immune Allorecognition Using Nanobiologics Effectively Overturns Ongoing T Cell Mediated Allograft Rejection 2305425
Abstract Introduction Acute T cell mediated rejection (TCMR) episodes are inadequately controlled by rejection treatment and impede long-term...
Exploring the antiviral potency of synthetic Cationic lipo-oligopeptides (CLOPs) against Herpes simplex virus type 1 2310162
Abstract Introduction Herpes simplex virus type 1 (HSV-1) is a common human pathogen that can infect sensory neurons and establish latency, w...
Extracellular vesicles and cytokines released from Pseudomonas aeruginosa infected macrophages activate cardiac fibroblasts 2259917
Abstract Introduction Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative, opportunistic pathogen and a major cause of severe pneumonia...
B cells facilitate immune evasion of metastasizing cancer cells in tumor-draining lymph nodes 2260657
Abstract Introduction Lymphatic colonization correlates with worse prognosis in several cancers, as lymph nodes act as a reservoir of maligna...
mRNA Nanotherapy targeting Kv1.3 channels enables in vivo reprogramming of T cells for cancer therapy 2260072
Abstract Introduction Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with a suboptimal immunotherapy response. T cell-...
A New Therapeutic Strategy for Multiple Sclerosis: DRAK2 Inhibition Promotes Induction of Regulatory T Cells via Metabolic Reprogramming 2256515
Abstract Introduction Multiple Sclerosis (MS) is an autoimmune disease where autoreactive T cells cause damage in the central nervous system....
Targeting IL-33 and TSLP in Asthma: Efficacy Assessment in Humanized Mouse Models 2302202
Abstract Introduction Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are key epithelial cytokines driving allergic inflammati...
Novel comparative models of canine tumors xenografted into mice to develop effective immunotherapies against osteosarcoma 2302620
Abstract Introduction Osteosarcoma (OSA) in dogs and humans is an aggressive form of bone cancer with limited effective treatment options for...
Long-distance communication between CD8 T cells and brainstem neurons determines sickness behaviors and infection outcome 2254620
Abstract Introduction CD8 T cells are classically known for their cytotoxic role in eliminating infected, cancerous, and damaged cells. Howev...
CD4 T cell specifically deplete tissue resident alveolar macrophage 2310198
Abstract Introduction Alveolar macrophages are lung tissue resident macrophages that play a critical role clearing particles, protecting from...