The Journal of Immunology
Articles in this Issue
Deciphering the role of extrafollicular-derived IgM on germinal center memory and long-lived plasma cell responses to Influenza virus infection 2257479
Abstract Introduction Most if not all the IgM secreted early after Influenza virus infection by B-1 and B-2 cells is derived from antibody-se...
Allogeneic Tissue Tregs Improve Disease Outcome in Models of Acute Lung and Kidney Injury 2259889
Abstract Introduction Foxp3+ T regulatory cells (Tregs) are important mediators of tissue homeostasis and immune tolerance, known for suppres...
High risk blood myeloid dysregulation is elevated in obesity and is reduced by lifestyle interventions 2251787
Abstract Introduction We recently described the Human Immune Dysregulation Evaluation Framework (Hi-DEF) to quantify myeloid and lymphoid dys...
The Role of Tyro3—Axl—Mertk Receptors in Uterine Immune Regulation During Pregnancy: A Multilevel Analysis in Mouse Models 2266974
Abstract Introduction Successful pregnancy requires immune tolerance and controlled inflammation at the maternal—fetal interface. The Tyro3—A...
Novel HIV-1 p24 Epitope Identified for the Amerindian HLA-B*39:02 Allele 2252620
Abstract Introduction HLA drives HIV evolution by selecting polymorphisms within the HIV proteome. HLA-B*39:02 is frequent in populations wit...
Toward a Pan-Arenavirus T-cell Vaccine: Identification and Preclinical Evaluation of Conserved Epitope constructs 2260477
Abstract Introduction Arenaviruses represent a rapidly expanding group of rodent-borne emerging human pathogens with significant pandemic pot...
IL-9 at the Maternal-Fetal Interface Drives a Novel Immunological Mechanism of Preterm Labor and Birth 2257559
Abstract Introduction Preterm birth (PTB) — the leading cause of neonatal morbidity and mortality - frequently arises from spontaneous preter...
Embryonic Stem Cell—Derived Signals as Potential Modulators of Prostate Tumor Cell Growth 2258320
Abstract Introduction Prostate cancer progression is influenced by the tumor microenvironment and soluble signaling factors. Mouse embryonic...
Discovery of Exhausted-like Lung Tissue-Resident Memory T Cells as Key Mediators of Protective Immunity 2257944
Abstract Introduction Respiratory viral infections, especially influenza, remain a major global health challenge, and circulating antibody-ba...
Amino-bisphosphonates enhance CD8+ T cell responses to vaccine antigens through an ATRAID-dependent mechanism involving the stromal compartment 2259959
Abstract Introduction Bisphosphonates (BPs) are a family of drugs that are widely used to prevent bone resorption. Recent retrospective epide...
Ultra-small Saccharibacteria modulate immunoactivation through type IV pili and TLR2 2259816
Abstract Introduction Saccharibacteria (TM7) are episymbiont, that grow on the surface of host bacteria such as Schaalia and Actinomyces (Act...
Engineering natural killer cells to express immunoglobulin A Fc receptor CD89 unlocks IgA-mediated cytotoxicity responses 2309809
Abstract Introduction Natural killer (NK) cells are critical effector cells of the innate immune system. Classically, NK cells mediate antibo...
Bacterial bunker-busters: Novel Immunotherapeutics against Pneumonic Plague 2253158
Abstract Introduction Yersinia pestis (Yp) is a gram-negative bacillus that causes plague in humans and animals and is endemic in Africa, Asi...
A critical role of epithelial MHCII in initiation of autoimmune tumorigenesis and sustaining premalignancy growth in the stomach 2300319
Abstract Introduction Autoimmunity is emerging as a new etiology for early-onset gastric cancer (GC), especially in young women, but it remai...
Endosomal TLRs govern disease-stage specific B cell responses in Sjogren’s disease 2257833
Abstract Introduction Sjogren’s disease (SD) is a systemic autoimmune disease that occurs primarily in women. While B cells play an essential...
Evaluating MMP9 Expression Across Cancer Cell Lines to Identify Models for Functional Analysis 2258440
Abstract Introduction Matrix metalloproteinase-9 (MMP9) is an extracellular enzyme that contributes to tumor invasion and metastasis through...
Using dynamic model building and simulation to understand cytokines and adaptive immunity 2258020
Abstract Introduction An immune response is mediated by a complex interconnected system of cells and molecules. Understanding these responses...
Aberrant NK Cell Migration and Differentiation Underlie Immune Dysregulation in Endometriosis 2259942
Abstract Introduction Endometriosis affects approximately 10% of women of reproductive age and remains a major clinical challenge due to its...
Single-cell RNA and CITE-seq analysis of human CD4+ T cells reveals age-associated upregulation of IL-32 2259951
Abstract Introduction Aging profoundly alters the human immune system, leading to increased vulnerability to infection, autoimmunity, and car...
Open resources and data from the Allen Institute: exploring immune health, rheumatoid arthritis, tissue immunity, and cytokine perturbations 2309948
Abstract Introduction A core goal of the Allen Institute is to openly share our immunological data and enable the immunology community to exp...
Immune Cell Derived 1,25(OH)2D3: A Critical Defense Against Influenza Infection 2257145
Abstract Introduction Immune cells have vitamin D receptors (VDR) making them direct targets of vitamin D. CYP27B1 is the critical enzyme tha...
A Cross-Species Nerve- and Airway-Associated Macrophage Program that Drives Lung Tumor Progression and Immunotherapy Resistance 2301331
Abstract Introduction Nerve- and airway-associated interstitial macrophages (NAMs) are a distinct subset of lung-resident macrophages with ke...
The Effects of Club Cell Protein 16 on Endothelial NFκB Signaling 2258195
Abstract Introduction Club Cell Protein 16 (CC16), one of the most abundant proteins in airway secretions, is primarily produced by Club Cell...
Prior antigen experience influences the development of alopecia areata in C3H/HeJ mice 2258436
Abstract Introduction Alopecia areata (AA) is an autoimmune disease of the hair follicle (HF) with a 2% lifetime incidence, characterized by...
The role of T cells in uterine turnover and homeostasis 2258113
Abstract Introduction The endometrium undergoes a coordinated and cyclic turnover that is unlike any other mammalian tissue. In mice, this pr...