The Journal of Immunology
Articles in this Issue
Targeting the FOXP3—T-bet interaction to restore Treg stability in IFN-γ—driven autoimmunity 2254306
Abstract Introduction Regulatory T cells (Tregs) maintain immune homeostasis through FOXP3-centered transcriptional complexes that tightly co...
Neutrophil Elastase Regulates both Innate and Adaptive Immunity in SARS-CoV-2-Infected Mice 2260457
Abstract Introduction Neutrophil elastase (NE), encoded by ELANE, is a serine protease that contributes to both antimicrobial defense and inf...
Integrative Multi-Omics Profiling Identifies Candidate Biomarkers in Triple-Negative Breast Cancer 2258118
Abstract Introduction Triple-negative breast cancer (TNBC) remains one of the most therapeutically resistant breast cancers and often display...
Dysregulated host responses are associated with severe influenza A virus disease in individuals with arterial hypertension 2335206
Abstract Introduction Influenza A virus (IV) infections cause seasonal epidemics, which remain a major cause of morbidity and mortality world...
Diabetogenic CD8 Tcells are highly adaptive in beta-cell antigen recognition 2258433
Abstract Introduction Type 1 diabetes (T1D) is an autoimmune disease in which cytotoxic CD8+ T cells destroy insulin-producing β cells throug...
Dietary exposure modulates cutaneous immunity and microbiota to facilitate wound healing 2308096
Abstract Introduction Nutrition influences all host physiological processes, yet its role in regulating tissue repair remains poorly understo...
Evaluation of Salmonella bearing Tumor-targeting Peptides for Cancer Therapy 2334639
Abstract Introduction Salmonella, known for its facultative anaerobic nature to replicate in tumors and ability to deliver foreign genes into...
The Immune Signatures Data Resource 2.0: An Expanded Compendium of Systems Vaccinology Datasets 2304506
Abstract Introduction Vaccines are among the most impactful public health interventions. Systems vaccinology leverages high-dimensional omics...
Investigating the antibacterial and pro-coagulant activity of neutrophil-derived extracellular vesicles induced by phagocytosis of S. aureus 2254459
Abstract Introduction Extracellular vesicles (EVs) are small nanosized particles with the ability to influence host-pathogen interactions. Th...
The Indigestible Burden of Microplastics Drives Bioenergetic Dysfunction in Macrophages 2260413
Abstract Introduction To date, over 7 billion tons of plastic waste has been generated, of which, 80% has accumulated in the environment. Mac...
Activity in vivo of in vitro expanded and adoptively transferred antigen-specific CD8+ T cells against neoepitopes that mediate tumor rejection 2306826
Abstract Introduction A subset of somatic passenger mutations in cancer cells lead to generation of peptides which can be presented by MHC I...
A Tonsil Organoid Model for Epstein-Barr Virus-Host Immune Interactions in Germinal Centers 2308488
Abstract Introduction Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that establishes lifelong persistence in B lymphocytes by ad...
A novel mice colitis model recapitulates human T cell and myeloid cell reconstitution to Support drug evaluation of inflammatory bowel disease 2258809
Abstract Introduction Inflammatory bowel disease (IBD) is a chronic autoimmune disorder of the gastrointestinal tract with complex pathogenes...
Multi-omics and longitudinal immune profiling uncover a distinct monocyte phenotype distribution and function in Kawasaki disease 2308476
Abstract Introduction Kawasaki disease (KD) is an acute childhood vasculitis marked by strong monocyte (MO)-driven innate activation. Despite...
Plasma IgM inversely correlates with coronary artery AS risk 2335222
Abstract Introduction B cells are important immune cells in murine atherosclerosis (AS), regulating lesion development in a subset-dependent...
Epigenetic Regulation of FosB in Mast Cells 2306012
Abstract Introduction Early life adversity (ELA) leads to increased chances of developing proinflammatory disorders like allergy later in lif...
Acute Fasting Suppresses Neutrophil Metabolism and Effector Function 2254957
Abstract Introduction Acute fasting is common in perioperative care and may create a transient window of vulnerability to hospital-acquired i...
Therapeutic treatment with a single CD4+ T cell epitope containing PLGA nanoparticles reverses CD8+ T Cell induced Type I Diabetes 2260609
Abstract Introduction T cell-mediated autoimmune diseases, such as type I diabetes (T1D) are mediated by autoantigen-specific CD4+ and CD8+ T...
Antibody-Mediated Entry Renders Non-Susceptible Macrophages Permissive to SARS-CoV-2 Replication 2307324
Abstract Introduction SARS-CoV-2 entry into epithelial cells via ACE2 is well characterised, but its interactions with alveolar macrophages r...
Fusion Peptide Priming and Trimer Boosting Strategies for HIV Vaccine Development in Guinea Pigs 2308606
Abstract Introduction Inducing broadly neutralizing antibodies (bnAb) is a central challenge in HIV vaccine development. The HIV envelope (En...
A rapid IL-9-secreting T cell response mediates uropathogenic Escherichia coli (UPEC) clearance in an acute UTI mouse model 2267492
Abstract Introduction Urinary tract infections (UTIs) are commonly caused by gut-derived pathogenic bacteria, such as Escherichia coli, that...
A BACH2-STAT5 transcriptional module licenses a short intracellular C3 proteoform in activated CD4+ T cells 2308647
Abstract Introduction IL-2-STAT5 signaling is vital for CD4+ T cell function, whereas BACH2 restrains activation. How these transcription fac...
MEX3B as a Potent Regulator of Inflammasome Signaling 2267250
Abstract Introduction Inflammasomes are crucial for innate immune defense to many microbial infections but are also subjected to stringent ce...
B cells induce the age-related accumulation of CD39+CD73+ CD8+ T cells 2305676
Abstract Introduction Even in “healthy” aging, adaptive immune cells become dysregulated, increasing age-associated B cells and exhausted and...
Unlocking Therapeutic Vulnerabilities in Leukemia with CRISPR-Based Screens 2255583
Abstract Introduction Background: Leukemia is a cancer of hematopoietic stem cells in the bone marrow. It is classified as lymphoid or myeloi...