The Journal of Immunology
Articles in this Issue
Directing Defense: ZBP1 Activation during MPXV Infection 2309240
Abstract Introduction Monkeypox virus (MPXV) remains a global health concern due to the recent outbreak that exhibited an increase in human t...
The Autoimmunity-Associated Minor Allele of PTPN22 Accelerates NK Cell Development and Augments Effector Function 2255984
Abstract Introduction Ptpn22 is expressed exclusively in immune cells and shows the highest expression in natural killer (NK) cells, yet its...
Non-invasive profiling of antigen-specific endometrial T cells via Menstrual Effluent 2249626
Abstract Introduction While human T cell responses are well-characterized in peripheral blood, little is known about their role in the female...
PD-1 regulates CD8+ T cell tissue resident memory differentiation and function following influenza infection 2260210
Abstract Introduction In addition to its established role in T cell exhaustion, PD-1 is also upregulated in CD8+ tissue-resident memory (TRM)...
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution 2218223
Abstract Introduction Neutrophils, the most abundant white blood cells and first responders to immune challenges, have long been considered s...
Novel Neuroprotective and Immunoregulatory Mechanisms for the Treatment of Multiple Sclerosis 2259190
Abstract Introduction Multiple sclerosis (MS) is a complex autoimmune disease involving myriad cell types with varied baseline immunological...
IL-1b-driven bystander proliferation of memory CD4 T cells partially depends on IL-2 2306098
Abstract Introduction Levels of the inflammatory cytokine IL-1b are elevated during aging and are associated with a number of morbidities inc...
Periodontal Pathogen—Derived Phosphoglycerol Dihydroceramides Attenuate Piezo1-Mediated Mechanosensing in Macrophages 2309477
Abstract Introduction Phosphoglycerol dihydroceramides (PGDHCs) produced by Porphyromonas gingivalis (Pg) are emerging virulence factors that...
Role of Neurotransmitter Transporters in Neuroimmune Communication and Cellular Responses 2256336
Abstract Introduction Measuring the dynamics of neurochemical-regulated immunity has been an area of research due to its implications in unde...
RGS16 as a Therapeutic Target to Overcome TGFβ-Induced Resistance in Adoptive T Cell Therapies 2250696
Abstract Introduction T cells, particularly CD8+ T cells, play a central role in immune defense against intracellular pathogens and in tumor...
In Vitro Characterization of Glioblastoma Inflammatory Signatures: Insights into Resistance and Model Selection 2260327
Abstract Introduction Glioblastoma multiforme (GBM) is a highly aggressive neurological cancer marked by treatment resistance and recurrence....
Gene expression profiling of immune cells in blood from patients with coronary Artery Disease 2235454
Abstract Introduction Coronary artery disease (CAD) is a leading cause of death worldwide and is increasingly recognized as an immune-mediate...
Mucosal vaccination with TLR9 agonists promote the development of tissue resident helper cells and mucosal humoral immunity against influenza 2259178
Abstract Introduction Current influenza (flu) vaccination strategies rely on accurate prediction of the circulating strains for the upcoming...
BHLHE40 Orchestrates ILC3 and RORγt+ APC-Mediated Barrier Immunity 2309149
Abstract Introduction A central feature of the intestinal immune system is its ability to protect against pathogens while maintaining toleran...
Neonatal Naïve CD8+ and CD4+ T Cells Exhibit Distinct Metabolic Profiles After Activation 2309657
Abstract Introduction Neonatal immune responses differ markedly from those of adults, partly due to distinct metabolic programs within immune...
Presentation by Virally Infected Cells of Antigenic Proteins Utilized in Natural Killer Cell Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) 2256335
Abstract Introduction The presence of viral proteins in the plasma membranes of infected cells is essential for natural killer (NK) cell anti...
Spike-specific de novo CD8+ T cell clones exhibit robust effector phenotypes in the context of hybrid immunity 2252473
Abstract Introduction Repeated SARS-CoV-2 exposures through infections and vaccinations shape memory CD8+ T cell responses. While exposure hi...
Interrelationship of Peritoneal Fluid and Mesothelial Macrophages and Species-Specific Pathways in Their Maintenance and Repopulation 2306939
Abstract Introduction The peritoneal cavity is a clinically important immune niche that regulates serosal organ homeostasis and contributes t...
Dual protein phosphatase promotes effector CD8+ T-cell persistence and tumor control 2241571
Abstract Introduction CD8+ T cell persistence is essential for long-term protection against cancer and infection. Immune checkpoint inhibitor...
SMAD7-Mediated Modulation of TGF-β Signaling Drives the Emergence of ex-Tissue-Resident CD8 T Cells in Autoimmune Uveitis 2259507
Abstract Introduction Tissue-resident memory T cells (TRMs) maintain local immune surveillance, yet their persistence and potential for egres...
Structural basis of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity 2299676
Abstract Introduction Anti-MHC-I mAbs in human and murine systems can stimulate immune responses to tumors and infections by competitively bl...
A follicular helper-like program enables T cell tolerance to ingested antigen 2309672
Abstract Introduction Extrathymic T cell tolerance towards innocuous antigen is mediated by 3 complementary mechanisms: deletion, anergy and...
CMV-specific clonal expansion of Th1, GZMK+ CD8+, and TEMRA T cells revealed by human PBMC profiling 2257482
Abstract Introduction Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with...
Central role of IL-10 in CNS-protection from Inflammatory Damage during Cryptococcus Meningoencephalitis 2253926
Abstract Introduction Cryptococcus neoformans meningoencephalitis (CM) is a highly lethal fungal disease. Th1/IFN-g are crucial for fungal cl...
Immune congestion drives dural sinus failure and lethal intracranial pressure in cerebral malaria 2308981
Abstract Introduction Cerebral malaria (CM) is a severe manifestation of Plasmodium falciparum infection affecting young children and causing...