The Journal of Immunology
Articles in this Issue
Dual Reporter multiplexing enables simultaneous detection of IgG and IgM antibodies against autoantigens and pathogenic proteins in human samples 2257943
Abstract Introduction Profiling both IgG and IgM antibodies against autoantigens and infectious disease targets provide insight into the immu...
Serpin B1 prevents severe pulmonary influenza through specific effects on T cells and NK cells 2334958
Abstract Introduction The murine serpin b1a gene protects against H3N2 influenza A viral induced pathogenicity but the natural protein is int...
Revealing NMOSD Molecular Mechanisms in an AQP4-Induced Animal Model 2261163
Abstract Introduction Neuromyelitis optica is a severe autoimmune disease of the central nervous system (CNS), mediated by autoantibody and T...
Stem-like and effector peripheral helper T cells orchestrate distinct local immune responses in rheumatoid arthritis 2262732
Abstract Introduction Peripheral helper T (Tph) cells can contribute to the pathogenesis of human autoimmune diseases. Although Tph cells are...
Cell death executioners driving PANoptosis 2259603
Abstract Introduction Cell death is a key effector mechanism to maintain homeostasis and drive immune activation and host defense. However, e...
Investigating tracheal repair and remodeling following influenza infection 2261104
Abstract Introduction The airway epithelium forms a critical barrier against inhaled pathogens and toxins, requiring rapid and coordinated re...
Narrowband ultraviolet B induces peripheral regulatory T cells to exert antigen-specific immune suppression 2308173
Abstract Introduction Commonly used to treat inflammatory skin diseases, narrowband ultraviolet B (UVB) has been shown to induce antigen-spec...
Extracellular cAMP as a potent immune modulator promotes T cell exhaustion in chronic lymphocytic leukemia 2306108
Abstract Introduction Cyclic adenosine monophosphate (cAMP) is a key intracellular second messenger known to regulate immune responses. Howev...
Regulatory T cells set a dynamic boundary between cellular and humoral immunity based on input signal kinetics 2258109
Abstract Introduction The adaptive immune system defends through two strategies: humoral immunity, mediated by antibodies that require long t...
A novel LNP/mRNA-based STING immunotherapy approach for chronic HBV infection 2334947
Abstract Introduction Chronic hepatitis B virus (HBV) infection remains a major global health burden. Current antiviral therapies suppress vi...
Local Antigen Encounter and a Type I IFN-IL-15 Axis Cooperatively Program Cytotoxic CD4 Differentiation and Tissue Residency 2261140
Abstract Introduction Cytotoxic CD4 T cells (ThCTL) are a distinct tissue-resident effector subset driving MHC-II- restricted cytotoxicity ag...
Integrated multiomics profiling reveals MS-specific molecular signatures linked to progression and response to nasal anti-CD3 (Foralumab) therapy 2267524
Abstract Introduction Chronic neuroinflammation in multiple sclerosis (MS) can persist independently of relapse activity, revealing mechanism...
Cardiac Responses to Klebsiella pneumoniae Infection; Investigating Its Role in Sepsis and Endocarditis 2251186
Abstract Introduction Sepsis causes nearly 11 million deaths across the globe and about 350,000 per year in the United States. Sepsis can be...
Regulatory T Cell—Derived Amphiregulin Consolidates Transplant Tolerance via EGFR-Mediated T Cell Exhaustion 2263100
Abstract Introduction Durable transplant tolerance remains a major challenge. Prior studies have linked amphiregulin (Areg) to Treg cell stab...
T Follicular Helper cell and CD8+ T Cell Dynamics in Breast Cancer: Insights from Patient Samples and Immune Checkpoint Blockade in Murine Model 2308437
Abstract Introduction Breast cancer (BC) in India shows distinct epidemiological features, yet immune profiling remains limited. We investiga...
Understanding the impact of polyethylene glycol (PEG)-lipids on mRNA-LNP vaccine immunogenicity 2260679
Abstract Introduction mRNA - lipid nanoparticle (LNP) vaccines developed against SARS-CoV-2 are a transformative technology and saved million...
Intranasal exposure to SARS-CoV-2 spike protein induces Th2 and Th17 cell-associated pulmonary immunopathology 2258252
Abstract Introduction SARS-CoV-2 spike—based vaccines control COVID-19, yet vaccine-associated enhanced respiratory disease (VAERD) after bre...
Experimental Validation of Variant Antibodies Guided by a Large Language Model and Optimized through Combinatorial Algorithms 2307181
Abstract Introduction Machine-learning—guided antibody design offers a promising approach for rapidly generating high-affinity therapeutics a...
Inducible expression of non-classical innate immune genes by a novel DAP-type peptidoglycan sensing and Toll signaling pathway 2266405
Abstract Introduction The Imd and Toll pathways regulate the Drosophila innate response, with each pathway activating distinct NF-κB factors...
Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression 2267628
Abstract Introduction Inflammation involves timed gene expression, suggesting that the fine-tuned onset, amplitude, and termination of expres...
Inflammatory Monocyte Responses and Endothelial Stress in Young Adult E-Cigarette Users 2253631
Abstract Introduction E-cigarettes (ECs) are increasingly used by youth and young adults, but their long-term health risks remain unclear due...
ELISA-Based Neutralizing Antibody (NAb) Detection as a Fit-for-Purpose Alternative to Cell-Based Assays for Biotherapeutic Immunogenicity Assessment 2266841
Abstract Introduction Neutralizing antibodies (NAbs) are a critical component of the adaptive immune response to biotherapeutic agents, capab...
A distal transcribed enhancer of KRAS fine-tunes Tfh-mediated vaccine response 2308711
Abstract Introduction Enhancer RNAs (eRNAs) are noncoding transcripts from active enhancers whose functions in adaptive immunity are poorly d...
TIDEPOOL, a method for inferring disease trajectories across cohorts, identifies neutrophil-driven trajectories associated with severity of infections 2260680
Abstract Introduction Inferring molecular signatures of disease progression usually requires costly and time-consuming longitudinal samples....
IL-4Rα mediated signalling on Foxp3+ T regulatory cells has a protective role during cutaneous Leishmaniasis 2258800
Abstract Introduction Forkhead box P3 (Foxp3+) T regulatory (Treg) cells are a unique subset of CD4+ T cells that play important immunomodula...