The Journal of Immunology
Articles in this Issue
Lymphocytic Variant Hypereosinophilic Syndrome is Composed of pathogenic CD4+ T cells with Features Distinct from those in T Cell Lymphoma 2300510
Abstract Introduction Lymphocytic variant hypereosinophilic syndrome (LHES) is an eosinophilic disorder characterized by phenotypically aberr...
The phenomenon of Fear of Missing Out (FOMO) has emerged as a significant psychological and behavioral challenge in contemporary education 2257142
Abstract Introduction FOMO, which is the widespread worry that others are experiencing rewarding moments that one is missing, is intensified...
The regulatory subunit ppp2r5a of protein phosphatase 2A selectively regulates spleen B-1 cell proliferation and accumulation 2257493
Abstract Introduction B-1 cells are a fetal/neonatal-derived B cell population located in small frequencies in the spleen. They are also the...
Design and Evaluation of a Novel Recombinant Antigen for a T Cell-Based Vaccine Against Valley Fever 2260372
Abstract Introduction Valley Fever (VF) is a potentially fatal fungal disease caused by Coccidioides; however, no clinical vaccine exists. We...
Establishing leukocyte reference values in seven wild-caught shark species 2259588
Abstract Introduction Immune assessment in wildlife populations is challenging. Peripheral blood sampling is a non-invasive approach in under...
The immunomodulatory potential of a medicinal plant-derived exosome-like nanovesicles and their applications in inflammatory skin disorders 2258926
Abstract Introduction Chronic immune-mediated skin disorders such as psoriasis and atopic dermatitis are characterized by epidermal hyperprol...
Changes in genes in the TLR signaling pathway within the lumbar spinal cord of doxycycline-inducible Tat transgenic mice following Tat induction 2254518
Abstract Introduction A common complication of human immunodeficiency virus (HIV)-1 infection is HIV neuropathy, which is often associated wi...
Epigenetic and lineage-specific transcription factors regulate the cell type specific induction of type I and type III interferons 2307867
Abstract Introduction Viral respiratory and mucosal infections affect millions of people in the USA and worldwide, creating a serious health...
Immune checkpoint blockade enhances CD4 effector function to control persistent viral infection 2267612
Abstract Introduction T cell exhaustion, a defining hallmark of chronic viral infections and cancer, is characterized by the progressive loss...
Activation, localization, and autoantibody production of tissue-based age-associated B cells in human type 1 diabetes 2257444
Abstract Introduction T cells mediate type 1 diabetes (T1D) pathogenesis, but mouse studies indicate that B cells function as critical antige...
Phagocytic CD206+ interstitial macrophages are remodeled after pneumococcal respiratory infection 2257592
Abstract Introduction Innate immune memory of lung macrophages is a crucial host safeguard against repeated respiratory infections. Based on...
T cell mediated dysregulation of bone marrow hematopoiesis in Glioblastoma 2260498
Abstract Introduction Glioblastoma (GBM) is an aggressive brain cancer which induces severe systemic immunosuppression. Systemically, immune...
Divergent roles for TLR7 and TLR9 in modulating the NFkB pathway in B cells 2261147
Abstract Introduction BCR signal strength plays a key role in the fate decision of B cells with strong BCR signals promoting plasma cell diff...
The Invisible Influence: Microbial Dynamics Impacting Tumor Immunity in NSCLC 2259273
Abstract Introduction Lung cancer remains a leading cause of cancer mortality, with non-small cell lung carcinoma (NSCLC) comprising over 80%...
Stimulating the resolution of inflammation overcomes CD8+ T cell exhaustion and boosts immunotherapy 2255409
Abstract Introduction PD-1 inhibition has revolutionized cancer therapy. However, despite the initial success of immune checkpoint inhibitors...
Investigating features of dengue immunity that drive enhancement versus protection 2307730
Abstract Introduction Secondary dengue virus (DENV) infection can lead to severe disease through antibody-dependent enhancement (ADE). Howeve...
Opposing Effects of Metoclopramide and Bromocriptine on Melanoma Response to Immune Checkpoint Blockade 2303237
Abstract Introduction Dual immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1 have been effective in treating advanced melanoma, y...
Tracking memory T follicular helper cells in the draining lymph node following boost vaccination in humans 2257551
Abstract Introduction T follicular helper (Tfh) cells are crucial in germinal center (GC) reactions, supporting B-cell maturation and long-te...
Impact of innate immune training on lung tissue resident memory formation following RSV infection 2328124
Abstract Introduction Trained immunity is a well-documented phenomenon which can mediate non-specific immunity against pathogens. Secondary c...
The Role of Pathogen-Restricted Paracrine Protection by T cells in Controlling Viral Infection 2260976
Abstract Introduction It is critical for the immune system to destroy cells harboring intracellular infection to remove pathogen burden. This...
Use of Pillars of Immunology to teach fundamental concepts of immunology to undergraduate students and create excitement for scientific enquiry 2261233
Abstract Introduction The field of immunology is of great interest to undergraduate students....
TIRTL-sequencing to interrogate the clonal repertoire of CARpos and CARneg TILs post CAR T-cell therapy for pediatric solid tumors 2259261
Abstract Introduction Post-immunotherapy, tumor infiltrating lymphocytes (TIL) expanded from solid tumors reflect immune responses within the...
Uncovering cellular programs and regulatory circuits governing cell fate bifurcations using interpretable machine learning 2255655
Abstract Introduction Understanding immune cell fate bifurcations requires deciphering how transcriptional and regulatory programs coordinate...
Sojadodamgangki-tang attenuates allergic lung inflammation by inhibiting T helper 2 cells and Augmenting alveolar macrophages 2307870
Abstract Introduction Sojadodamgangki-tang (SDG) is a traditional East-Asian herbal medicine mainly composed of Pinellia ternate (Thunb.) Mak...
IL-17A Enhances CD8+ T Cell Metabolism to Restrict West Nile Virus in the Brain 2305958
Abstract Introduction West Nile virus (WNV) is the leading viral agent responsible for human neurological diseases in North America. Currentl...