The Journal of Immunology
Articles in this Issue
Tissue-directed maintenance of human B-cell memory after vaccination and infection 2260241
Abstract Introduction Vaccines differ in their efficacy and durability of protection. Clinical titer studies show that some, e.g. measles, co...
Regulatory Role of MSMB in Lymphoma and Its Tumor Suppressor Function Across Cancer Types 2258421
Abstract Introduction Lymphoma is a globally prevalent malignancy driven by diverse genetic alterations. Identifying novel genes that influen...
Parasympathetic neural regulation of immune tolerance in corneal allografts via inhibition of dendritic cell activation and T cell polarization 2253341
Abstract Introduction This study aimed to investigate the role of the parasympathetic nervous system in the allorecognition and rejection of...
An Intracellular C3-CFB Complement Axis Reprograms Tubular Metabolism and Chromatin to Drive Kidney Fibrosis 2307504
Abstract Introduction Complement is often viewed as liver-derived and extracellular, yet many non-hepatic cells generate intracellular comple...
Evidence for Human Thymopoiesis in a Porcine Thymus Graft and T Cell Tolerance to the Source Pig in a Human Recipient of a Thymokidney Xenotransplant 2254531
Abstract Introduction Porcine thymic transplantation tolerizes xenogeneic recipients to the porcine source animal in animal models. A 54-year...
Protective Immunity after DNA Vaccination against Pneumonic Plague Using a Needle-Free Jet Injection Platform 2253077
Abstract Introduction Yersinia pestis (Yp), a facultative anaerobic gram-negative bacillus, causes plague, which if untreated has a case-fata...
Increasing the Efficacy of Chemotherapy by Rescuing the Innate Immune Response 2309649
Abstract Introduction Despite advancements in immunotherapy, more than half of melanoma patients will either not respond or will later relaps...
HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors 2258016
Abstract Introduction Peptides presented by class-I Human Leukocyte Antigen (HLA-I) proteins provide the basis of immune surveillance. Conver...
CD96 as a target to reverse aryl hydrocarbon receptor mediated immune suppression in aged individuals 2260343
Abstract Introduction Influenza virus is a major source of morbidity and mortality throughout the world. The majority of deaths and hospitali...
Therapeutic intranasal delivery of NanoSTING provides broad protection against seasonal and highly pathogenic influenza strains 2258688
Abstract Introduction Seasonal and highly pathogenic influenza strains pose major public health challenges. Broad-spectrum therapies that pro...
Diverse resident memory T-cell subsets differentiate in tumors to promote antitumor immunity and response to immune checkpoint blockade immunotherapy 2254428
Abstract Introduction The accumulation of CD103+CD8 resident memory T (TRM) cells in tumors is predictive of a response to PD-1 blockade. How...
Early Growth Response 2 (EGR2) Regulates Late B Cell Differentiation and Double-Negative T Cells in Lupus-Prone MRL/lpr Mice 2307921
Abstract Introduction Early Growth Response 2 (EGR2) is a zinc-finger transcription factor known to regulate T cell activation and tolerance;...
BCR Density Regulates IgE Germinal Center B Cell Survival 2254802
Abstract Introduction IgE antibodies mediate allergic disease, yet IgE+ B cells rarely persist in germinal centers (GCs). Low B cell receptor...
Mapping Galectin-3 Ligand Networks Driving Renal Fibrosis Using Proximity-Labeling Proteomics 2253572
Abstract Introduction Galectin-3 (Gal-3) is a β-galactoside—binding lectin implicated in inflammation, epithelial injury, and fibrosis. Altho...
Macrophage—Treg immunopathology in mucosal chronic graft-versus-host disease defined by single-cell and spatial profiling 2309654
Abstract Introduction Chronic graft-versus-host disease (cGVHD) is an alloimmune complication of allogeneic hematopoietic stem cell transplan...
HSV-2 Infection Induces Lasting Transcriptional and Functional Changes in Vaginal Tissue NK Cells 2258179
Abstract Introduction Mucosal immunity in the vaginal tract (VT) remains poorly defined despite its essential role in defense against sexuall...
Role of Microbial Tryptophan Metabolism in Th17 Activation and Multiple Sclerosis 2260431
Abstract Introduction The relationship between diet, the gut microbiota, and immune cells influences autoimmune diseases such as multiple scl...
Human Microbiota-Driven Mouse Model Improves Drug Metabolism Prediction 2258986
Abstract Introduction Drug—microbiome interactions are increasingly recognized as critical in pharmacology. The gut microbiome influences dru...
Dynamic but Unified Changes in the Perinatal Thymus Promote Distinct Waves of Treg Generation 2254735
Abstract Introduction The thymic environment enforces tolerance by inducing autoreactive T cells to either undergo negative selection or dive...
Characterization Of Usutu Virus Replication And Associated Immune Response In Vitro 2308012
Abstract Introduction Usutu virus (USUV), a mosquito-borne flavivirus, is an emerging public health concern capable of causing neurological d...
Strategically leveraging Influenza A induced trained immunity to shape immune profiles to subsequent vaccination with heterologous antigens 2309699
Abstract Introduction Trained immunity, the epigenetic and metabolic reprogramming of innate immune cells upon inflammatory signaling shapes...
S-1117, an engineered pan-IgG cleaving enzyme, reduces IgG BCR mediated B cell activation and removes Fc fragments from tissue-bound anti-AChR IgG 2253830
Abstract Introduction Autoreactive IgGs and BCRs trigger tissue damage in autoantibody-mediated diseases. IgG and BCR degradation using S-111...
Perivascular macrophage regulates sympathetic innervation density in adipose tissue 2309701
Abstract Introduction Metabolic balance within adipose tissue is tightly controlled by both the peripheral nervous system and the local immun...
Ancestry-Informed Transcriptomic Analysis Identifies YY1 Axis Disruption and Stromal Program Loss in African American Prostate Cancer 2258332
Abstract Introduction Prostate cancer (PCa) shows racial disparities, with African American (AA) men experiencing higher incidence and worse...
Characterization of the brain immune microenvironment in healthy mice and a human infant with AT/RT 2260665
Abstract Introduction Atypical Teratoid/Rhabdoid Tumors (AT/RT) are devastating brain tumors with high mortality. Due to rare occurrence in i...