The Journal of Immunology
Articles in this Issue
Evaluating Bruton Tyrosine Kinase Inhibition in T-Cell Leukemia and Lymphoma Models 2258370
Abstract Introduction Bruton’s Tyrosine Kinase (BTK) is a cytoplasmic kinase best known for its role in B-cell receptor signaling, but aberra...
Multimodal Interrogation of Autoimmune Disease Patients Reveals Highly Diverse Biomarker Signatures 2259778
Abstract Introduction Autoimmune diseases (AIDs) like multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel dise...
Modulatory Effects of Mdivi-1 on OxLDL-Induced Metabolic Alterations, Inflammatory Responses, and Foam Cell Formation in Human Monocytes 2253928
Abstract Introduction Atherosclerosis, a leading cause of cardiovascular disease, is characterized by lipid accumulation and chronic inflamma...
TREM-1-mediated modulation of innate immune response in acute and chronic inflammation: Effect of treatment timing and cell specificity on outcome 2223031
Abstract Introduction Triggering receptor expressed on myeloid cells 1 (TREM-1) is a promising target in inflammation-related diseases such a...
Reconstructing Immune Time from a Single Snapshot: The Single-Cell Brownian Bridge Framework for Reverse-Time Evolutionary Inference 2248645
Abstract Introduction Modeling the temporal evolution of the immune system remains a central yet unsolved challenge in computational immunolo...
Serum factor regulation of mast cell desensitization following combined immunotherapy 2308953
Abstract Introduction Our laboratory recently developed cell culture systems allowing selective differentiation of MCs co-expressing tryptase...
Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710
Abstract Introduction Stem cell-derived β cells offer a promising strategy for Type 1 diabetes (T1D) treatment, yet the mechanisms driving im...
Interferon Regulatory Factor 5 modulates CD11b+ cell composition and NLRP3-related factors in emphysema pathogenesis 2258665
Abstract Introduction Although interferon regulatory factor 5 (IRF5) is known to play a central role in inflammation, its function in chronic...
Ebola virus exploits host lncRNA LINC01740 to enhance ATF3 and suppress antiviral immune responses 2259953
Abstract Introduction Ebola virus (EBOV) causes a highly lethal hemorrhagic fever marked by uncontrolled cytokine release and impaired antivi...
Glucose Uptake by Germinal Center B Cells Selectively Sustains Autoimmunity While Sparing Responses to Foreign Antigens 2255581
Abstract Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that features persistent germinal center (GC) format...
Transcriptional and post-translational regulation of B7-H4 2258098
Abstract Introduction Immune tolerance mechanisms are shared between cancer and pregnancy. By cross-analyzing single-cell RNA sequencing data...
Translational control of T cell expansion and autoimmune responses by a non-conventional RNA binding protein 2252845
Abstract Introduction Naïve CD4+ T cells respond to antigenic stimulus and rapidly transition into active state by intensifying clonal expans...
Targeting the Adenosine—Adenosine Deaminase-1 Axis to Restore HIV-Specific CD8+ T Cell Function 2309228
Abstract Introduction Despite suppressive antiretroviral therapy (ART), HIV reservoirs rapidly rebound upon treatment interruption, driven in...
Antibodies in Guillain-Barré syndrome, the immune system’s double-edged sword 2332889
Abstract Introduction Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide, and a majority of isolates express an o...
Defining the Stress—Gut Microbiome Interplay in Anti-Tumor B Cell Response 2247381
Abstract Introduction Chronic psychological stress is a major driver of cancer progression, yet its effects on anti-tumor B cell immunity rem...
Opa1 Regulates iNKT Cell Differentiation Through Control of TCR Signaling 2260028
Abstract Introduction Invariant natural killer T (iNKT) cells are innate-like T cells with rapid effector functions. Distinct metabolic progr...
The Impact of Age-Associated Lymph Node Microenvironment Changes On Dendritic Cell:CD4+ T Cell Interactions During Germinal Center Initiation 2255775
Abstract Introduction Germinal center (GC) formation in lymph node (LN) follicles is essential for generating high-affinity antibodies follow...
Uncovering a role of aryl hydrocarbon receptor (AhR) in the differentiation dynamics of human B cells 2258222
Abstract Introduction Upon activation, B cells differentiate into plasmablasts (PBs), germinal center (GC) B cells, and memory B cells (MBCs)...
eQTL analysis of SLE B cells reveals functional genomic regulatory variation associated with autoimmunity 2253669
Abstract Introduction Systemic lupus erythematosus (SLE) is a complex and heterogenous autoimmune disease characterized by the expansion of e...