The Journal of Immunology
Articles in this Issue
TLR4—Spike Interaction Mediates Metabolic Reprogramming in Human B Cells 2256897
Abstract Introduction Viral infections intricately modulate B cell immunity, yet the precise underlying mechanisms remain elusive....
Multivariate Host-Pathogen Interactions Driving Heterogeneous Response to Influenza 2265319
Abstract Introduction Influenza infections differ greatly among individuals, with controlled human infection studies showing wide variation i...
Immune Modulation of T Cell Dysfunction in Tibia Fracture Model of Complex Regional Pain Syndrome 2260770
Abstract Introduction Complex regional pain syndrome (CRPS) is a debilitating chronic pain disorder with no effective treatments. Increasingl...
Development of a novel preclinical immunocompetent model of glioblastoma that reflects tumor heterogeneity 2260765
Abstract Introduction Glioblastoma is an aggressive, lethal brain tumor with limited treatments and poor patient survival. Several murine tum...
Epigenetic Tumor Suppressor KMT2D Shapes the Immune Landscape in Pancreatic Cancer 2335260
Abstract Introduction KMT2D (known as Mll4 in mice) is a histone methyltransferase and a critical epigenetic regulator frequently mutated acr...
Effects of dietary fiber on the intestinal humoral immune response via interactions with the microbiota 2260105
Abstract Introduction The Western diet, rich in fats and low in fermentable fibers, has been associated with a range of immune-mediated infla...
T cells play a protective role in maintaining spinal health after intervertebral disc injury 2308705
Abstract Introduction The intervertebral disc (IVD) is an essential joint of the spine that is prone to injury and exhibits limited regenerat...
CD1d Modulation Influences Tumor Immune Crosstalk in Triple-Negative Breast Cancer (TNBC) through NKT and Macrophage Interaction 2257312
Abstract Introduction TNBC remains an aggressive malignancy with immunosuppressive microenvironment. The lipid antigen-presenting molecule CD...
Enhancing Immunology Learning through Team-Based Learning (TBL): A Multi-Cohort Study in Undergraduate Medical Education 2267327
Abstract Introduction Immunology is perceived as a challenging subject in medical education due to its abstract concepts, cross-disciplinary...
ScRNA-seq Analysis of Olfactory Epithelium in Chronic Rhinosinusitis with Nasal Polyps 2261022
Abstract Introduction Olfactory epithelium inflection is associated with olfactory dysfunction, but the specific target cells and regulatory...
Measurement of the Reduction of OC-43 Coronavirus Production by Natural Killer Cell Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) 2260991
Abstract Introduction The expression of OC-43 coronaviral proteins in the plasma membranes of infected cells [that are needed to support anti...
IFNαR1/R2 heterodimer recombinant protein significantly enhanced Type 1 IFN binding and induced diverse antibody responses in mice 2260333
Abstract Introduction Type I interferons play a crucial role in regulating immune responses through the IFNα/β receptor (IFNαR). IFNαR is a h...
Dysregulated Myelopoiesis and Altered Neutrophil Metabolism in Obese Adults: A Role for Glutaminase in Hypoxia-Induced Cell Survival 2260130
Abstract Introduction Obesity is associated with myelopoietic dysfunction, metabolic abnormalities, and low-grade inflammation. This study in...
Self-reactive CD4+ T cells display diverse differentiation in health and gain stem-like features in rheumatoid arthritis 2308930
Abstract Introduction Self-reactive T cells have long been associated with autoimmune diseases, yet they are also a physiological component o...
Dietary Reversal of Dyslipidemia Ameliorates CD1b-Autoreactive T Cell-Mediated Skin Inflammation 2257438
Abstract Introduction Unconventional group 1 CD1 (CD1a, b, and c)-restricted T cells recognize self/microbial lipid antigens and play importa...
Decoding the Role of Resident Tissue Macrophages in Controlling Local Iron Levels and Supporting Organ Function 2309623
Abstract Introduction Iron is an essential micronutrient for nearly all organisms, yet how its balance and distribution are maintained at the...
Tbet+CD11c+ B cells depend on CD36 for expansion and effector function during obesity 2258257
Abstract Introduction CD21- CD23- CD11c+ Tbet+ B cells expand in primary immune and peripheral tissues during chronic conditions such as agin...
Discordant Anti-SARS-COV-2 IgA Responses In Blood, Saliva, and Tears 2261177
Abstract Introduction To determine whether anti-SARS CoV-2 IgA responses in blood reflected the expression of anti-SARS CoV-2 IgA in mucosal...
Schistocephalus solidus suppresses melanomacrophages, IgM+, and CD4+ cells but not IL-17 expression in threespine stickleback (Gasterosteus aculeatus) 2260422
Abstract Introduction Immunoregulation is critical for maintaining an organism’s health, as excessive or deficient immune responses can lead...
Clonal Persistence of Tissue-Adapted CD4+ T Cells Drives Recurrent Oral Mucosal Inflammation 2309294
Abstract Introduction The oral mucosa is a major immunological barrier and a primary site of interaction between the host immune system and t...
Uncovering T cell antigens in sarcoidosis 2308956
Abstract Introduction Sarcoidosis is characterized by the accumulation of clonally expanded CD4+ T cells within affected tissues, strongly im...
MAIT cells support Treg response to UV light in healthy skin and restrain CD8 activation in lupus skin 2257500
Abstract Introduction MAIT cells are innate-like T cells enriched in barrier sites, including the skin, that exhibit both repair and inflamma...
Cancer Cell Mediated Mitochondrial Transfer Reprograms Macrophage Metabolism and Polarization 2309895
Abstract Introduction Mitochondria are regulators of cellular metabolisms, redox balance, and survival. Their dysfunction has been shown to a...
Adrenergic Signalling Drives Accumulation of Myeloid-derived Suppressor Cells in the Liver During Stress 2258331
Abstract Introduction Psychological stress, due to exposure to environmental and/or emotional stressors, has long been associated with immune...
CD4+ T cell-mediated Immune Surveillance during Intestinal Tumor Initiation 2262796
Abstract Introduction While the immune system’s role in tumor development has been broadly studied in established tumors , how the immune sys...