The Journal of Immunology
Articles in this Issue
Cyclodextrin-Based Nano-Immunotherapy Enhances Dendritic Cell Activation to Drive Anti-Tumor Immunity in Bladder Cancer 2334395
Abstract Introduction High risk non muscle invasive bladder cancer is commonly treated with intravesical BCG therapy, yet many patients fail...
Discovery and validation of novel IgA proteases for the treatment of autoimmune and inflammatory diseases 2328257
Abstract Introduction IgA is a multifunctional immunoglobulin essential for maintaining tolerance to commensal bacteria in the gut lumen and...
Investigating immune checkpoint blockade of LY-6A protein as cancer immunotherapy in mice 2330710
Abstract Introduction Ly-6A is a potential immune checkpoint on T cells. Evidence suggests that overexpression of Ly-6A diminishes T cell res...
Tumor-innervating nociceptors drive immuno-suppressive monocyte differentiation to prevent T cell-mediated anti-cancer immunity 2259756
Abstract Introduction Nociceptors — peripheral nervous system neurons that trigger the sensation of pain or itch in response to noxious stimu...
Multiphoton Imaging of Regulatory T Cell and Oligodendrocyte Interactions During Neural Stem Cell Transplantation in Autoimmune Encephalitis 2308362
Abstract Introduction Multiple Sclerosis is an autoimmune disease of the central nervous system (CNS) characterized by demyelination and neur...
A novel hydrophilic nanoparticle mRNA-based platform to deliver antigen-specific immune therapies in autoimmune diseases 2334959
Abstract Introduction We developed NanoGalaxy™ a hydrophilic nanoparticle (HNP) platform, to deliver mRNA to spleen antigen-presenting cells...
Heterogeneity of mechanical responses of αβ T-cell receptors 2257683
Abstract Introduction Alpha beta T cell receptors (TCRs) recognize target ligands, antigenic peptide-loaded major histocompatibility complex...
Decoding the Antibody Reactome at Scale with Novel Antigen Display Technology to Decipher Immune History 2335216
Abstract Introduction The human immune system serves as a ledger of environmental exposures, infections, and self-reactivity and there is a t...
Single cell profiling identifies effector CD8+ T cells and peripheral helper T cells as drivers of recurrent immunotherapy mediated arthritis 2328826
Abstract Introduction Immune checkpoint inhibitor (ICI) therapy is often associated with inflammatory arthritis (ICI-IA). However, the mechan...
Investigating Inflammasome Responses to Pathogenic Fungi 2331094
Abstract Introduction Fungal pathogens are increasingly recognized as important activators of the innate immune system, particularly through...
Amphiregulin production from regulatory T cells does not require autocrine or paracrine feedback signaling 2260280
Abstract Introduction Pneumonia triggers inflammatory responses followed by recovery and tissue repair. T regulatory (Treg) cells play a nece...
Discovery of potent, selective and insurmountable MRGPRX2 antagonists for mast cell-driven disorders 2308475
Abstract Introduction Mas-related G protein—coupled receptor X2 (MRGPRX2) is an important mediator of non-IgE—dependent mast cell activation...
Understanding long term consequences of respiratory viral infection 2260810
Abstract Introduction In the wake of the SARS-CoV-2 pandemic, most people have experienced at least one respiratory viral infection and many...
The ascorbate-Tet axis is a checkpoint regulator of naive T-cell quiescence 2257733
Abstract Introduction T-cell peripheral tolerance is crucial for maintaining immune homeostasis and preventing autoimmunity, which is charact...
Interferon lambda 4 genotype determines baseline expression of interferon-stimulated genes and lipid metabolism-related genes in the healthy liver 2304507
Abstract Introduction Interferon lambda 4 is an ancestral protein produced in the presence of the rs368234815-delta-G allele. This haplotype...
Impact of Pre-Existing Adenovirus Immunity on Vaccine Immunity Induced by ChAdOx1 nCoV-19 in Immunodeficient Patients 2330644
Abstract Introduction Chimpanzee adenovirus—vectored COVID-19 vaccines, including ChAdOx1 nCoV-19 (nCoV-19), were selected in part due to low...
Leveraging Advances In Long-Read Sequencing to Improve Analysis of Host Immune Responses 2332674
Abstract Introduction Short-read based technologies have dominated high-throughput sequencing workflows for years. However, many complex sequ...
Bivalent vaccination fails to enhance conserved spike T cell responses across BetaCoronaviruses 2260452
Abstract Introduction The COVID-19 pandemic highlighted the need for vaccines strategies that elicit broad T cell-mediated immunity against e...
Age-Linked Neutrophilic Inflammation Signatures Associate with Disease Severity in Primary Ciliary Dyskinesia 2309093
Abstract Introduction Primary ciliary dyskinesia (PCD) is characterized by chronic neutrophil-predominant airway inflammation, yet spirometri...
Limosilactobacillus reuteri-educated T cells protect against activation of liver inflammation in immunocompromised mice 2229185
Abstract Introduction Oral administration of probiotic Limosilactobacillus reuteri DSM 17938 prolongs survival and reduces Th1- and Th2-assoc...
Immunomodulatory Effects of Lactococcus lactis on the Gut—Pancreas Axis 2257747
Abstract Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of pancreatic beta cells by T...
Meningeal lymphoid hubs support autoreactive immune responses 2306190
Abstract Introduction Immune cells within the meninges are increasingly recognized as key regulators of CNS homeostasis and disease. The dura...
Canonical WNT pathway utilizes LEF1 to coordinate innate immune memory 2335059
Abstract Introduction Wnt signaling is a fundamental and evolutionarily conserved pathway that governs cell fate, proliferation, and tissue h...
Characterization of Immune Cell Populations in Lupus Nephritis Using a SignalStar® Multiplex Immunohistochemistry Assay 2332985
Abstract Introduction Systemic Lupus Erythamatosis (SLE) is a chronic autoimmune disease characterized by dysregulated immune response, produ...
Flow Cytometric Antigen-Specific Immune Responses in Latent Tuberculosis Infection: A Comparison Between Low- and High-Endemic TB Settings 2260608
Abstract Introduction Screening individuals with latent tuberculosis infection (LTBI) from regions with varying TB endemicity is critical for...