The Journal of Immunology
Articles in this Issue
SLE risk variants shapes IRF5 alternative promoter isoform usage in B cells 2252005
Abstract Introduction Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease driven by a complex interplay of genetic and en...
Antibody-Drug Conjugates (ADCs) as Adaptors for Universal CAR T cells 2259384
Abstract Introduction Antibody—drug conjugates (ADCs) and chimeric antigen receptor (CAR) T cells are powerful cancer therapeutics, but each...
Persistent uterine inflammation following murine chorioamnionitis predisposes to poor outcomes in a subsequent pregnancy 2310301
Abstract Introduction Chorioamnionitis, an infection and/or inflammation of the placenta and fetal membranes, is a leading cause of preterm b...
De novo generation of innate memory-like T cells occur early during human immune development 2254423
Abstract Introduction Infants rely heavily on innate immunity while adaptive memory develops. A subset of T cells, termed “virtual memory” or...
Imaging Flow Cytometry Enhances Characterization of Immune Cell Phenotype and Function 2255710
Abstract Introduction The addition of cellular imaging to high-speed, single-cell flow cytometry has revolutionized simultaneous immunophenot...
DUSP22 dysregulation and UBR2 upregulation induce T-cell receptor signaling and systemic lupus erythematosus 2256861
Abstract Introduction Downregulation of DUSP22 in peripheral blood T cells is correlated with human systemic lupus erythematosus (SLE) nephri...
Streamlined and cost-effective 96-well plate NGS assay for single-cell immune receptor chain pairing and T/B cell immunophenotyping 2260349
Abstract Introduction To facilitate the discovery of epitopes or immune therapy targets for researchers without ready access to expensive ins...
Combokines: Platform for Cytokine Delivery in aAPC Engineering 2252933
Abstract Introduction CAR-T therapy is promising, but poor T cell expansion causes up to 13% of patients to drop out. Traditional bead-based...
Hematopoietic stem and progenitor cells overcome treatment resistance to immune checkpoint inhibitors in preclinical gliomas 2240834
Abstract Introduction Glioblastoma (GBM) is one of the most lethal primary brain tumors, with dismal survival. Immune checkpoint inhibitors (...
CD137 and IFN-γ signaling in mature cDC2Bs play a central role in the regulatory feedback mechanism for alloimmune responses 2328469
Abstract Introduction Conventional dendritic cells (cDCs) are a prototype of professional antigen-presenting cells that dictate T-cell activa...
An integrated cell atlas of the innate lymphoid cells in health and disease 2254590
Abstract Introduction Innate lymphoid cells (ILCs) represent a highly diverse family of lymphocytes that play pivotal roles in tissue homeost...
Dissecting transcription factor networks for tissue-resident CD8 T cell differentiation and maintenance 2255891
Abstract Introduction Tissue-resident memory (Trm/TDRM) T cells populate non-lymphoid tissues and provide a first line of defense against pat...
Spatial immunoprofiling of human colon in health and disease: insights into inflammation 2256907
Abstract Introduction Inflammatory bowel diseases (IBD) are chronic, relapsing inflammatory conditions of the gastrointestinal tract. Despite...
Activation-induced marker (AIM) assay to detect Chlamydia trachomatis-specific T cells in highly exposed women 2261007
Abstract Introduction Natural immunity to Chlamydia trachomatis (CT) develops in some women but is weak and requires sensitive assays. Activa...
T-T cell crosstalk: Insights into mechanisms and disease development 2254071
Abstract Introduction Intercellular signaling is essential for immune coordination and cellular identity. While interactions between innate a...
Skull bone marrow is an early source of antiviral CD8 T cell priming and expansion during neurotropic virus infection 2241010
Abstract Introduction The anatomical locations of generating adaptive immune responses to neurotropic viruses are still being investigated. S...
Pulse Qualification Technology 2306501
Abstract Introduction In a typical flow cytometer, the signal generated by a single cell crossing the focused light beam produces an electric...
Nutritional Regulation of PKCζ: Omega-3 Fatty Acids Shape Neonatal T Cell Development 2255253
Abstract Introduction Infants born to mothers with a family history of allergy often display transiently low cord blood T cell (CBTC) protein...
IFNAR and STING signaling restrict proliferation of hapten- primed CD8 T cells producing IFNγ in response to skin sensitization 2255903
Abstract Introduction Contact hypersensitivity (CHS) is a CD8 T cell-mediated response to hapten skin sensitization and challenge. While sens...
Natural Antibody Recognition of DAMPs Is Required for Inflammasome-Driven Anti-Tumor Immunity 2257202
Abstract Introduction Damage-associated molecular patterns (DAMPs) released from malignant cells are known to induce immune responses. Natura...
Bispecific T Cell Engagers Sensitize the Glioblastoma Tumor Microenvironment to Immune Checkpoint Blockade Responsiveness 2261116
Abstract Introduction Glioblastoma (GBM) is the most aggressive brain tumor, accounting for ∼48% of all brain malignancies in children. Despi...
The transcription factor IRF8 promotes the survival of differentiated effector CD8 T cells 2254435
Abstract Introduction CD8+ T cells depend on IL-2 signals to drive effector differentiation and sustain clonal expansion, yet how IL-2—respon...
High-resolution spatial mapping of cell state and lineage dynamics in the tumor microenvironment with PEtracer 2302205
Abstract Introduction The tumor microenvironment is a complex ecosystem of cancer, immune, and stromal cells. Within this environment, cancer...
N. brasiliensis priming in three different inbred strains of mice provides protection to influenza A virus challenge in a strain dependent manner 2307446
Abstract Introduction N. brasiliensis (Nb) is a helminth that induces extensive type 2 remodeling in the lung due to its migration route thro...
SP2H selectively depletes Stimulator of Interferon Genes (STING), reducing inflammation and improving survival in Trex1-/- mice 2255319
Abstract Introduction STING contributes to the pathogenesis of autoimmune diseases, e.g. systemic sclerosis (SSc) and lupus (SLE). SP2H is a...