The Journal of Immunology
Articles in this Issue
Development of a sensitive assay for detection of pre-existing antibodies to de-risk biotherapeutic molecules for immunogenicity 2259345
Abstract Introduction Using proprietary Invisi-B and Invisi-T machine learning tools, our IMPACT platform allows us to remove B and T cell ep...
Lymphocyte Inhibition by Cell Wall Components of Batrachochytrium dendrobatidis (Bd) 2333163
Abstract Introduction The chytrid fungus, Batrachochytrium dendrobatidis (Bd), is linked to continuing global amphibian population declines....
Aim2 inflammasome dependent IL1β/IL-18/Gasdermin D signaling is required for initiation of stress erythropoiesis in anemia of inflammation 2258281
Abstract Introduction Anemia of inflammation (AI) accompanies chronic inflammatory diseases. While steady-state erythropoiesis makes ∼2.5 × 1...
The inflammatory response and immune cell status following radiation exposure influence the host’s susceptibility to new infections 2306220
Abstract Introduction Tissue-targeted and whole-body irradiation (WBI) are widely used to treat patients with solid tumors and hematologic ma...
Immunophenotyping of T-cell Responses from Immunocompromised Hosts in Response to Vaccination 2255680
Abstract Introduction Immunocompromised hosts, including those with lymphoid or hematological malignancies and solid organ transplant recipie...
Upregulation of Fatty Acid Metabolism in Activated Synovial CD4 T Cell Populations in Rheumatoid Arthritis 2259803
Abstract Introduction Rheumatoid arthritis (RA) is an autoimmune disease involving joint damage driven by infiltrating immune populations. Th...
Hybrid Cytometry: automated live-cell tracking with a final snapshot of fixed-cell phenotyping to study immune-synapse dynamics 2263890
Abstract Introduction Even advanced flow cytometry and fluorescence microscopy fall short in linking dynamic immune cell functions and phenot...
Distinct Immune Signatures are Associated with Exposure History in Human Malaria 2259590
Abstract Introduction As a surrogate to interrogating the diverse human immune response to natural malaria, we examined responses to four seq...
UCD200/206 scleroderma-prone chickens show aberrant innate immune function 2335106
Abstract Introduction Non-communicable diseases (e.g., autoimmunity) typically are multifactorial diseases, requiring genetic, immune system,...
Exogenous IFNα Impairs Neural Communication by Disrupting Endothelial Mitochondrial Function at the Blood-Brain Barrier 2258446
Abstract Introduction Type I interferon alpha (IFNα) is essential to maintain immune surveillance, but, when abnormally elevated, drives neur...
Investigation of the role of the cystic fibrosis transmembrane conductance regulator (CFTR) in SARS-CoV-2 pathogenesis 2308341
Abstract Introduction Acute lung injury and persistent inflammation caused by SARS-CoV-2 may lead to further complications after the virus ge...
Whole Body Irradiation (WBI) impairs antigen-independent functions of memory CD8 T cells 2255916
Abstract Introduction Radiation exposure is increasing due to its expanding use in the medical, energy production, and space travel industrie...
Investigating Cytotoxic Function in CD4+ T-cells for Cancer Immunotherapy 2260082
Abstract Introduction T-cell-based immunotherapies like ACT have mostly focused on CD8 T cells, but cytotoxic CD4 T cells (CD4 CTLs) are incr...
miR-10a induces IL-33/ST2 signaling and Tregs to promote adipose browning and attenuate adipose tissue inflammation 2253749
Abstract Introduction Obesity is a pandemic, characterized by infiltrating macrophages and T cells in adipose tissue (AT) which triggers chro...
Bridging the Gap in Flow Cytometry Training: A Practical Workflow for Teaching Autofluorescence Management in Immunology 2261098
Abstract Introduction Cellular autofluorescence, caused by endogenous biomolecules, can obscure low-intensity fluorophore emissions, leading...
Design and evaluation of engineered MyD88 fusion proteins for enhancing CAR-T therapy 2333869
Abstract Introduction MyD88 is a scaffold protein that plays a key role in propagating innate immune signals. Recent work has shown that a ch...
Mitochondrial ATP production links chromatin accessibility to T cell differentiation and function 2258461
Abstract Introduction Immune elimination of chronic infection or cancer requires cytotoxic CD8 T cells that adopt and maintain an effector ph...
Interrogating T-Cell Receptor Interactions with Peptide-MHC Through Structure-Guided Mutational Analysis 2219106
Abstract Introduction Studies have shown that germline contacts may underlie MHC restriction, supporting the idea that TCR—MHC specificity is...
Macrophage migration inhibitory factor as a microbial modulator of colitis-associated colorectal cancer 2256450
Abstract Introduction The gut microbiome is altered in inflammation and colorectal cancer (CRC), yet how proinflammatory factors induce dysbi...
Enhancement of Regenerative Activity Subsequent to SenoVax(TM) Senolytic Immunotherapy Cholesterol controls the pore-forming activity of mammalian gasdermins 2260188
Abstract Introduction Pyroptosis is a lytic form of cell death that requires pore formation by members of the gasdermin family of proteins. G...
“Do not eat me’’: LILRB4 signaling as a novel macrophage immunotherapy in lung cancer 2254327
Abstract Introduction Lung cancer is the leading cause of cancer-related deaths. Although current T cell-targeting immunotherapies have impro...
Regulation of neutrophil activity by novel potato-derived peptide 2261086
Abstract Introduction Neutrophils, key effectors of innate immunity, respond through phagocytosis, degranulation, and release of neutrophil e...
Synergistic Activation of TLR Adaptors MyD88 and TRIF Induces Inflammatory Cell Death in Infection 2260795
Abstract Introduction Severe infections often cause life-threatening inflammation, multi-organ failure, and death. During infection, pathogen...
IRF1 tunes the IRF4—IRF8 axis to drive effector B-cell fates in autoimmunity and inflammaging 2258675
Abstract Introduction Interferon regulatory factor 1 (IRF1) links IFNs and TLR signals to lymphocyte programs, yet its role in B cells and sy...
Early-life Fungal Colonization Reveals Stage-specific Immune Regulation in the Oral Mucosa 2241171
Abstract Introduction Neonates possess a developing immune system, which is different from adults as a result of initially living in a semi-a...