The Journal of Immunology
Articles in this Issue
Peripheral memory T cells with self-renewing properties increase with tumor-targeting IL-12 immunocytokine therapy 2308731
Abstract Introduction Stem-like memory T cells (TSCM) are a rare subset of multipotent, self-renewing cells important for antitumor control....
Development and Therapeutic Evaluation of a Uniform Lymph Node Cell Transfer Model of Alopecia Areata 2256823
Abstract Introduction Alopecia areata (AA) is an autoimmune disease characterized by non-scarring hair loss, primarily mediated by cytotoxic...
T-Cell Synaptosomes Orchestrate Long-Term Anti-Tumor Immunity via Proliferative and Metabolic Reprogramming 2266860
Abstract Introduction T-cell activation requires intimate contact with antigen-presenting cells (APCs), during which activated T cells deposi...
SPIC-dependent erythrophagocytic macrophages promote bacterial tissue persistence during Salmonella infection 2309292
Abstract Introduction Macrophages maintain tissue homeostasis by phagocytosing spent cells, recycle nutrients, and mounting antimicrobial res...
Characterization of Anti-influenza B Hemagglutinin Antibodies 2248890
Abstract Introduction Influenza B viruses continue to cause seasonal outbreaks around the world. The mismatch between vaccine and circulating...
Mycobacterium tuberculosis inhibits nuclear factor erythroid 2-related factor 2 (NRF2) activity via type 1 interferon production 2259864
Abstract Introduction Mycobacterium tuberculosis (Mtb), the primary causative agent of human Tuberculosis (TB), is the leading cause of infec...
Targeting a cancer cell Interferon-TBK1 signaling axis attenuates inflammatory memory mediated resistance to immune checkpoint blockade 2257735
Abstract Introduction Acquired resistance in cancer is a major obstacle to durable response after immune checkpoint blockade (ICB). While int...
Pseudomonas instigates neutrophil accumulation in adipose tissue and insulin resistance in obesity 2309070
Abstract Introduction Obesity is a global pandemic, with over 75% of the U.S. population classified as overweight or obese. Adipose tissue in...
TH17 responses elicited by a BcfA-containing vaccine protects against B. bronchiseptica disease and respiratory tract bacterial burden in mice 2257134
Abstract Introduction Bordetella bronchiseptica (Bb) is a respiratory pathogen of farm and companion animals. Current vaccines do not prevent...
Meta-inflammation Enhances Migration and Invasion of Prostate Cancer Cells via S100A4 Signaling 2267403
Abstract Introduction Prostate cancer is one of the most commonly diagnosed cancers in American men and a leading cause of cancer-related dea...
Unsupervised clustering identifies a CD161+ MAIT-like T cell population associated with anti—PD-1 response and immune-related toxicity in melanoma 2309523
Abstract Introduction Manual gating has been the standard for cytometry analysis but does not scale well to high-parameter panels. Unsupervis...
Loss of the Vitamin D Receptor Exacerbates Influenza Severity Through Dysregulated Immunity and Elevated Parathyroid Hormone 2249087
Abstract Introduction Respiratory infections caused by influenza viruses remain a global health burden, with disease severity in part determi...
Functional Dynamics of Cytotoxic CD4+ T cells in Acute and Chronic Viral Infections 2259913
Abstract Introduction Classically CD4+ T cells are recognized for their helper functions in coordinating adaptive immunity; however recent st...
ICAM-1 Adhesion Molecules Facilitate Immune Cell Docking at the Cribriform Plate Perineural Microenvironment in Aging 2258099
Abstract Introduction With aging, the immune system releases pro-inflammatory factors causing chronic inflammation or “inflammaging”. Within...
Role of polyunsaturated fatty acids in regulating innate immune antiviral and inflammatory response during respiratory syncytial virus infection 2309103
Abstract Introduction Respiratory syncytial virus (RSV) infection causes of hyper-inflammatory lung diseases such as pneumonia and bronchioli...
nELISA high-throughput proteomic profiling of RADIOHEAD: insights from the largest plasma study of patients receiving checkpoint inhibitor therapy 2257210
Abstract Introduction Proteomics holds great promise for cancer immunotherapy, with intensive efforts being exerted for early disease identif...
Pulmonary immunomodulation by nitroalkenes: implications for asthma-associated inflammation 2267798
Abstract Introduction Allergic asthma remains a global health concern, due to its increasing prevalence and limited treatment options. This h...
Feasibility and Immunological Impact of Reusing Wild-Type C57BL/6 Mice in Systemic and Cutaneous Anaphylaxis Models 2309549
Abstract Introduction The reuse of laboratory animals across compatible immunological procedures offers a strategy to reduce animal numbers i...
Burn Baby Burn: Leveraging Fatty Acid Oxidation to Improve CD8+ T cell Efficacy Against Ovarian Cancer 2250461
Abstract Introduction CD8+ T cell differentiation upon activation is heavily influenced by type and availability of local nutrients. However,...
Helminth infection induces neuroimmune remodeling and clinical remission in a mouse model of multiple sclerosis 2260051
Abstract Introduction The central nervous system (CNS) is under constant immunosurveillance and is influenced by immune-related effector mole...
The Scavenger Receptor/Fatty Acid Translocase CD36 Promotes Optimal Expansion and Activation of CD11c+ T-bet+ B Cells 2258145
Abstract Introduction B cells expressing the pro-inflammatory transcription factor T-bet have been implicated in a variety of disease states,...
Targeting IRF5 with selective covalent oral small molecules attenuates Type I IFN and pro-inflammatory cytokine secretion in human PBMCs and in mice 2309520
Abstract Introduction Interferon regulatory factor 5 (IRF5) is an undrugged transcription factor strongly associated with autoimmune diseases...
Why do we need a New Bloom’s Taxonomy for Gen Z? 2257384
Abstract Introduction Gen Z has grown up in a digital-first world where multitasking, quick information processing, and visual learning are e...
Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident T follicular helper cells in humans 2258382
Abstract Introduction CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue...
Xenotransfusion of Triple-Knockout Porcine Red Blood Cells: Effects of hCD55/hCD39 Expression and Anti-CD154 Therapy in Non-Human Primates 2234209
Abstract Introduction Global aging and emerging infectious diseases threaten the stability of blood supplies, underscoring xenotransfusion as...