The Journal of Immunology
Articles in this Issue
Intranasal SARS-CoV-2 vaccine boosting alters immune imprinting and B cell repertoire 2331448
Abstract Introduction Immune imprinting is a phenomenon in which prior antigen exposure limits variant-specific de novo immune responses to s...
Cellular ancestry determines plasma cell diversity 2257317
Abstract Introduction Plasma cells (PCs) secrete antibodies with diverse specificities and isotypes. PCs also exhibit differences in cellular...
Endoplasmic reticulum stress as a determinant of Mycobacterium tuberculosis survival in alveolar macrophages 2259865
Abstract Introduction Alveolar macrophages (AMs) are the first innate immune cells to encounter Mycobacterium tuberculosis (M.tb) following n...
Cytokine Programming Combined with 4-1BB Enrichment Enhances Ovarian TIL Expansion and Function 2260346
Abstract Introduction Ovarian cancer remains the most lethal gynecologic malignancy and the fifth leading cause of cancer-related deaths in w...
ViSENet: Joint Sequence and Structure Embeddings of Spike Proteins for Predicting Viral Dynamics 2310110
Abstract Introduction Predicting which viral strains will become predominant is challenging for vaccine design and therapeutic development. V...
Targeting mannose receptor (CD206)+, pro-fibrotic macrophages to halt lung fibrosis progression in chronic graft-versus-host disease 2251444
Abstract Introduction TGFβ−secreting, CD206+ profibrotic macrophages (macs) are key chronic graft-versus-host disease (cGVHD) drivers. Global...
Harnessing the homeostatic proliferation capacity of memory CD8+ T cells to restore immune memory after radiation exposure 2253074
Abstract Introduction While lymphopenia elicits vigorous homeostatic proliferation and memory phenotype acquisition among naive CD8+ T cells,...
Reels in Classroom Teaching: Enhancing Engagement and Learning 2256286
Abstract Introduction The integration of short-form videos, known as reels, into classroom teaching has transformed how educators deliver ins...
Gamma-Delta T cell—microglia crosstalk drives CD8+ T cell infiltration and promotes Alzheimer’s-like pathology in APP/PS1 mice 2257327
Abstract Introduction Neuroinflammation is a central feature of Alzheimer’s disease (AD), driving neuronal injury, synaptic dysfunction, and...
High-Throughput Immunomodulator Screening Reveals Subtype-Specific Responses in Low-Abundance Immune Cell Populations Using Scalable scRNA-seq 2260031
Abstract Introduction Understanding immune cell variability including rare populations is essential for dissecting inflammatory mechanisms an...
B Cells Under Pressure: How Losing Desmosterol Fuels Atherosclerosis 2260473
Abstract Introduction Atherosclerosis is an inflammatory disease characterized by plaque buildup in vessels. Cholesterol homeostasis is cruci...
WDFY1 is a key adaptor protein in Axl receptor tyrosine kinase signaling 2310082
Abstract Introduction The WD repeat and FYVE-domain containing protein 1 (WDFY1) encodes a phosphatidylinositol 3-phosphate (PI3P) binding pr...
Impaired IFNγ transcription and translation drive tumor-specific CD8 T cell dysfunction 2252067
Abstract Introduction Tumor-specific CD8 T cells (TST) are often dysfunctional and fail to produce IFNγ, a cytokine essential for tumor elimi...
Intrinsically disordered sequence in the ZMIZ1 drives leukemic activity, regulates protein stability and biomolecular condensate formation 2253537
Abstract Introduction T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer in children and adults, marked by the uncontr...
SARS-CoV-2-induced IL-6 paralyzes DC function through maturation impairment and immunosuppressive DC3 expansion 2256903
Abstract Introduction Severe COVID-19 is characterized by profound dendritic cell (DC) dysfunction, yet the molecular drivers remain poorly d...
Elevated type I interferon levels during Influenza virus infection profoundly suppress pulmonary innate and adaptive immunity and exacerbate disease 2257518
Abstract Introduction Most mouse studies aimed at investigating the roles of specific cytokines in disease states use mice deficient for the...
Short-term rapamycin treatment of an older human cohort alters immune and inflammatory markers but fails to re-set the epigenetic biological clock 2259884
Abstract Introduction Pharmacological inhibition of the mTOR pathway with rapamycin (RAPA) extends lifespan and improves aspects of healthspa...
Unbiased Transcriptomic Clustering Reveals an Inflammatory PEC Niche Associated with Cytokine and RAAS Signaling in Glomerular Disease 2260566
Abstract Introduction Kidney diseases are a major cause of morbidity and mortality worldwide. Glomerular pathologies constitute a substantial...
Stk11 loss in lung adenocarcinoma increases tumor CXCL16 and is associated with an expansion of Areg+ CXCR6+ IL-17-producing γδ T cells 2310280
Abstract Introduction gd T cells have been shown to both promote tumor growth/metastasis and to efficiently kill tumor cells. These contrasti...
A novel engineered cytokine immunotherapy reduces clinical features of disease in a mouse model of steroid-resistant asthma 2253062
Abstract Introduction Asthma is a disease of chronic airway inflammation associated with heterogenous immune phenotypes. While current immuno...
Meta-Data Informed Microphysiological System Replicates in vivo Macrophage Regulation of CD8+ T Cell Migration in Renal Cell Carcinoma 2254287
Abstract Introduction CD8+ T cells are abundant in clear cell renal cell carcinoma (ccRCC) yet are often retained at the tumor margin, a hall...
Characterizing Host-Viral Interaction Interfaces for Insights into Viral Transmission and Infections 2257274
Abstract Introduction Viruses hijack human cellular machinery through protein—protein interactions (PPIs). Since interaction interfaces play...
Metabolic Regulation during Stress Erythropoiesis 2257677
Abstract Introduction During Anemia of Inflammation (AI), pro-inflammatory cytokines skew hematopoiesis towards myelopoiesis and impair homeo...
The mTOR pathway in pristane -induced lupus models 2218025
Abstract Introduction mTOR signaling is overactive in systemic lupus erythematosus (SLE) and plays a key role in the disease pathogenesis by...
Delineating the role of CXCR6 for the formation and maintenance of CD8+ tissue-resident memory T cells in the gut 2260742
Abstract Introduction The CXCR6-CXCL16 axis has emerged as a critical regulator of T cell migration across various barrier tissues, thereby s...