The Journal of Immunology
Articles in this Issue
New insights into the regulation of γδ T cells in diabetic wounds 2254952
Abstract Introduction Diabetes is a widespread metabolic disorder. One of its most severe complications is diabetic foot ulcers (DFUs)-open w...
Highly dynamic dural sinuses support meningeal immunity 2308983
Abstract Introduction The central nervous system is surrounded by three interconnected meningeal membranes, including the dura mater, which c...
IL-33 Expands M2 Macrophages population and Restrains Inflammatory Monocyte Recruitment During Clostridioides difficile Infection 2332432
Abstract Introduction Antibiotic exposure predisposes to Clostridioides difficile infection (CDI) by disrupting intestinal immune homeostasis...
Ozureprubart, a next-gen anti-IgE antibody, inhibits IgE binding to FcαRI, dissociates FcαRI-bound IgE, and reduces FcαRI expression on basophils 2258455
Abstract Introduction Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic inflammatory diseases. Omalizumab, the only...
From Marrow to Model: a human bone marrow-derived neutrophil assay to study neutrophil development and function 2257049
Abstract Introduction Neutrophils play critical roles in innate immunity, autoimmune disease and cancer, however drug development to target t...
CD3-epsilon/delta heterodimer recombinant protein induced diverse antibodies binding to Jurkat cells and primary T cells in mice 2260655
Abstract Introduction The T cell receptor (TCR)/CD3 complex is assembled by pairwise interactions involving the formation of dimers of CD3 ep...
Reduced BCMA Signaling Disrupts the BAFF/APRIL Axis and Promotes Inflammatory Cytokine Production by B Cells in Multiple Sclerosis 2258573
Abstract Introduction Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. While anti-CD20 therapies reduce...
Characterization of the circulating T-cell landscape in cutaneous lichen planus patients 2266750
Abstract Introduction Cutaneous lichen planus (cLP) is a T cell—mediated skin disease in which cytotoxic CD8+ T cells attack basal keratinocy...
Identification of a FoxP3-specific small molecule degrader with potent antitumor immunotherapeutic efficacy 2309510
Abstract Introduction T regulatory cell (Treg) infiltration and accumulation within solid tumors leads to tumor immune evasion and is a major...
Mapping immune landscapes and immunopathomechanisms of inflammatory skin diseases through single-cell multi-omic analysis 2334083
Abstract Introduction Inflammatory skin diseases are a heterogeneous group of chronic disorders characterized by persistent or recurrent infl...
Subunit Vaccination Using Atomic Layering Thermostable Antigen and Adjuvant (ALTA®) Platform Elicits Enhanced Humoral and Cellular Immune Responses 2258445
Abstract Introduction Creating effective and thermostable vaccines is of significant relevance for global health. The Atomic Layering Thermos...
Defining viral-host mechanisms of neuroinflammation after human metapneumovirus infection 2257071
Abstract Introduction Human metapneumovirus (hMPV) is a leading cause of severe respiratory illness in infants, and can lead to the rare deve...
The Intestinal Microbiome Differentially Modulates SARS-CoV-2-Induced Pathology and Host Immune Response in Male and Female Mice 2261020
Abstract Introduction Several reports have shown disparity in male and female responses to SARS-CoV-2 infection. Males often develop move sev...
Targeting the KRAS G12D mutant suppresses tumor growth in a syngeneic mouse cholangiocarcinoma model through activation of immune cells 2258895
Abstract Introduction Cholangiocarcinoma (CCA), is an aggressive malignancy often diagnosed at an advanced, inoperable stage, with 5-year sur...
Distinct Inflammatory Programs Underlie the Intramuscular Lipid Nanoparticle Response 2267321
Abstract Introduction Developments in mRNA Lipid nanoparticle (mRNA/LNP) technologies have heralded a new era of both vaccines and therapeuti...
CD4-Targeted CAR-Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia 2224687
Abstract Introduction Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor prognosis. Current Immunotherapies, incl...
Early-Life Overnutrition Reprograms Metabolism and Immunity to Promote Sex-Biased CNS Autoimmunity 2333917
Abstract Introduction Multiple sclerosis (MS) is a chronic autoimmune disease with a strong female bias and no curative therapy. MS incidence...
IL-10 suppresses adaptive immune responses during Borrelia burgdorferi infection 2258748
Abstract Introduction Borrelia burgdorferi (Bb), the causative agent of Lyme disease, causes persistent infections in their reservoir hosts,...
Neutrophil Reprogramming Fuels Immunosuppression in Staphylococcus aureus Biofilm Infection 2256977
Abstract Introduction Neurosurgical procedures such as craniotomies carry up to a 15% infection risk, predominantly due to Staphylococcus aur...
Inhibition of Fatty Acid Metabolism in Alloreactive T Cells Minimizes Acute Graft-versus-host Disease 2303327
Abstract Introduction Acute Graft-Versus-Host Disease (GVHD) is a complication of allogeneic blood and marrow transplantation in which allore...
From Mouse to Clinic: Non-Invasive Swab-Based Profiling of Inflammatory and Barrier Markers in Atopic Dermatitis 2258968
Abstract Introduction Atopic dermatitis (AD) is a chronic inflammatory skin disease driven by immune dysregulation and impaired barrier funct...
Rapid Assembly of Oligo Pools into Medium-Scale T Cell Receptor Lentiviral Libraries 2267508
Abstract Introduction Synthesis and construction of T cell receptor cDNA is one of the main bottlenecks to large-scale T cell receptor (TCR)...
Functionally divergent resident memory T cells localize to lung and lymph node following influenza infection 2220996
Abstract Introduction Resident memory T cells (TRM) mediate localized immunity in barrier tissues while central memory T cells (TCM) recircul...
Characterization of γδ TCR ligand expression using a novel Vγ4Vδ7 TCR tetramer 2335176
Abstract Introduction γδ T cells are evolutionarily conserved innate-like T cells that have been implicated in infectious disease, autoimmuni...
Glucocorticoids redirect naïve T cells to the bone marrow for preservation in malnourished mice 2253552
Abstract Introduction Malnutrition impairs immunity and contributes significantly to child mortality. This depressed immunity involves the im...