The Journal of Immunology
Articles in this Issue
Lymphotoxin Beta Receptor Activity in Fibroblasts Regulates Collagen Synthesis and is Crucial for Lung Fibrosis 2309700
Abstract Introduction Pulmonary fibrosis is a hallmark of severe asthma and other chronic lung diseases and is driven by fibroblast-mediated...
Development of a Protective Cellular Therapy to Prevent Graft Versus Host Disease Post Allogenic Hematopoietic Stem Cell Transplant 2331939
Abstract Introduction Graft-versus-host disease (GVHD) remains a primary cause of morbidity and mortality post-allogeneic hematopoietic stem...
Assessing Potential Additivity of Proinflammatory Cytokines and Kifunensine on ADCC Potency 2309647
Abstract Introduction Antibody-dependent cell mediated cytotoxicity, or ADCC, is a process where antibodies coat a target cell, recruiting ef...
Structural Characterization of the Human West Nile Virus Antibody Response 2259814
Abstract Introduction West Nile Virus (WNV) is a mosquito-borne Flavivirus capable of causing febrile and neuroinvasive disease. Rising infec...
Comprehensive and Automated Mouse Immune Profiling with CyTOF Technology Reveals Aging-Associated Alterations in Lymphoid and Pulmonary Tissues 2259224
Abstract Introduction Immunosenescence disrupts surveillance and contributes to age-related diseases, yet its mechanisms remain incompletely...
The Impact of Neutrophils on the Resolution of Post-Surgical Pain 2306258
Abstract Introduction It is well established that the immune system contributes to the development of chronic pain, however the intricacies o...
Neutrophil—endothelial crosstalk after skin UV exposure orchestrates renal repair in health but drives profibrotic remodeling in lupus 2258618
Abstract Introduction Neutrophils can remigrate from UV-exposed skin to the kidney, but how they instruct renal structural cells is unclear....
Development of T-cell-based immunotherapy against chronic Hepatitis B infection 2309924
Abstract Introduction Even though T cells are known to be essential for Hepatitis B virus (HBV) clearance, there is currently no FDA-approved...
Elevated TGF-β/IL-10 in platelet-monocyte complexes exacerbates atherosclerosis in people with HIV 2252272
Abstract Introduction People living with HIV (PLWH) are more susceptible to atherosclerosis (AS). Here, we examine the functional consequence...
Heterogeneity in the Naïve CD8+ T Pool Shapes the Infection Response 2309970
Abstract Introduction Naïve CD8+ T cells are classically viewed as a uniform population that expands upon infection to protect the host again...
Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension 2259853
Abstract Introduction T cells critically contribute to hypertension, a condition affecting nearly half of American adults and driving cardiov...
Dietary Iron Overload Rewires Regulatory T Cells into IL-17—Mediated Proinflammatory Effectors Aggravating Yersinia enterocolitica Infection 2259908
Abstract Introduction Iron is indispensable for host physiology but, when in excess, fuels inflammatory and infectious diseases. The mechanis...
Human Macrophages Modulate Neutrophil Transendothelial Migration in an Inflammation-on-a-Chip Model 2255264
Abstract Introduction Dysregulated neutrophil function contributes to chronic inflammatory diseases, including ANCA-associated vasculitis, ye...
Therapeutic treatment with PD-1 agonist antibody prevents progressive autoantibody increase in murine autoimmune disease models 2258756
Abstract Introduction Autoimmune diseases are chronic inflammatory conditions with no complete cure. Repeated inflammatory episodes against s...
Investing the Role of IFI35 on Cell Viability Following Bacterial and Viral Infection by means of a Novel Human IFI35 Knock Out Respiratory Cell Line 2309817
Abstract Introduction Viral infections, such as Respiratory Syncytial Virus (RSV) or SARS-CoV-2, can trigger a widespread antiviral immune re...
Targeting SERPINA3 in Gliomas Extends Survival and Reprograms the Immune Landscape 2260933
Abstract Introduction Malignant gliomas remain the most lethal cancers, with WHO grade IV having a 5-year survival rate below 7 percent. Thes...
IL-17A+ γδ T Cells Are Compromised by ICU-Associated Sleep Fragmentation, Increasing Pneumonia Susceptibility 2310058
Abstract Introduction Critically ill patients experience profound sleep disruption and are at high risk for bacterial pneumonia. Using a muri...
Reoxygenating the Tumor Microenvironment with Biomimetic Hemoglobin Nanoparticles Enhances Chemo, CAR-T, and Gene Therapies 2260007
Abstract Introduction Tumor hypoxia diminishes antitumor immunity by stabilizing HIF-1α, promoting M2-like macrophage polarization, and impai...
Antigen-driven MAIT cell activation restores skin Treg levels and attenuates lupus-like skin inflammation 2257534
Abstract Introduction MAIT cells are innate-like T cells with both repair and inflammatory capacity. Their role in inflammatory skin disease...
IgM antibodies and B cells are early responders during acute secondary viral infections and contribute to protection from severe disease 2255909
Abstract Introduction IgM antibodies comprise 5% of serum antibodies and are thought to be a primary (1°) and weak immune response. Yet, isol...
Bridging the gap : CD8αß+ γδ T cells at the frontline of neonatal respiratory immunity 2259032
Abstract Introduction The observation that infants are more susceptible to some pathogens but resistant to others has long puzzled our unders...
Regulatory T Cells Act as Tolerogenic Antigen Presenting Cells to Suppress Autoimmunity 2310009
Abstract Introduction Professional antigen presenting cells (APC) initiate most T cell responses, but human T cells express MHC-II post-activ...
Pharmacological activation of LANCL2 provides immunometabolic protection from disease and lung pathology in mouse models of asthma 2260965
Abstract Introduction Asthma is a chronic, complex, immunological disease that afflicts over 28 million people in the U.S. Current therapies...
ImmuneSpace in 2026: A Centralized Repository for Curated Human Immune-Profiling Data 2310296
Abstract Introduction ImmuneSpace (immunespace.org) is a freely accessible database that hosts curated human immune-profiling data from a wid...
Engineered Nanobodies for Durable Tolerance in Allergic Asthma 2260092
Abstract Introduction Allergic asthma is caused by hypersensitivity to airborne allergens such as dust mites and pollen. Current treatment in...