The Journal of Immunology
Articles in this Issue
A Traditional Herbal Formula Attenuates Chronic Pruritus by Inhibiting IgE—FcεRI Signaling and Sensory Neuron Activation 2333596
Abstract Introduction Chronic pruritus is a debilitating symptom accompanying various inflammatory and dermatologic diseases, yet currently a...
Double-Negative T Cells Induce Ferroptosis-Dependent, MHC-Independent Cytotoxicity of CD8+ T Cells Against AML 2256323
Abstract Introduction Acute myeloid leukemia (AML) is a blood cancer originating from myeloid cells in the bone marrow with poor prognosis. C...
Ultra-Sensitive Cytokine Quantification Using Binding Oligo Ladder Detection: A Universal Signal-Amplification Strategy for Standard Immunoassays 2308422
Abstract Introduction Accurate quantification of low-abundance cytokines is essential for resolving early immune activation, subtle inflammat...
Linking zygosity and allelic balance to phenotype with programmable heterozygous editing and allele-specific single-cell RNA sequencing 2307550
Abstract Introduction Heterozygous single-nucleotide variants cause many inborn errors of immunity (IEI), yet most functional genomics tools...
Viral (LCMV) coinfection decreases the number of pathogenic Th17 cells in the CNS and prevents demyelinating disease 2309860
Abstract Introduction Multiple sclerosis is a chronic autoimmune demyelinating disease impacting 2.9 million people worldwide. Despite the si...
Neutrophil Extracellular Traps Prime B Cell—Mediated Fibrogenesis in MASH by Silencing HES1 and Promoting Plasma Cell Differentiation 2261119
Abstract Introduction Metabolic dysfunction—associated steatohepatitis (MASH) is a severe form of metabolic dysfunction—associated steatotic...
Introduction of a remediation process to support student learning in veterinary immunology 2308929
Abstract Introduction The veterinary curriculum is challenging, and individual students sometimes need additional opportunities to assimilate...
Acquired Digital Fibrokeratoma Presenting In a Patient With WHIM (Warts, Hypogammaglobulinemia, Infections, Myelokathexis) Syndrome 2333706
Abstract Introduction WHIM syndrome is a primary immunodeficiency disorder with an estimated prevalence of 1 in 5 million live births and les...
Discovery and delineation of human antibody-secreting cell subsets 2256534
Abstract Introduction Antibody-secreting cells (ASCs) differentiate from B cells after immune activation and home to inflamed tissues or to s...
Characterizing the role of ovarian hormones in regulating sex differences in baseline immune parameters 2309498
Abstract Introduction Sex differences among peripheral blood mononuclear cells (PBMCs) have been previously described in humans, including gr...
The role of the T-cell receptor (TCR) in the generation of lung CD4+ tissue-resident memory T cells (TRM) following influenza infection 2307595
Abstract Introduction Upon initial antigen encounter, anti-influenza T cells infiltrate the lung and form tissue-resident memory T cells (TRM...
Tumor Egfl6 is a new driver of neutrophil extracellular traps (NETs) in ovarian cancer 2310080
Abstract Introduction Ovarian cancer (OvCa) is characterized by immunosuppressive tumor microenvironment (TME). We displayed the tumor-secret...
Discovery of novel antifungal candidates for coccidioidomycosis through integrated drug screening and proteomics 2261274
Abstract Introduction Inhalation of airborne Coccidioides species causes coccidioidomycosis, a severe respiratory disease ranked as a signifi...
Identification of Coccidioides specific T cell clones and antigens in naturally exposed Pig-tailed Macaques and Valley fever patients 2308943
Abstract Introduction Coccidioidomycosis (Valley fever (VF)) is frequently misdiagnosed and mistreated as bacterial or viral pneumonia due to...
Immune alteration in the CNS tissues during peripheral influenza infection 2333891
Abstract Introduction Growing evidence suggests that peripheral infections contribute to neurodegenerative disease progression and cognitive...
Guanylate-Binding Protein 5 (GBP5) Exacerbates Sepsis by Inhibiting STING-mediated Post-Golgi Transport 2256813
Abstract Introduction Excessive activation of STING is associated with sepsis. Maintaining appropriate self-limiting mechanisms following STI...
Decoupling Drug Exposure, Binding ADA, and Functional Neutralization in Anti—PD-L1 Therapy Using Orthogonal ELISA Immunogenicity Assessment 2309558
Abstract Introduction Immune checkpoint inhibitors targeting PD-L1 can trigger anti-drug antibody (ADA) responses with varied biological effe...
Bioactive Enhanced Adjuvant Chemokine Oligonucleotide Nanoparticles (BEACON) for Mucosal Vaccination Against Genital Herpes 2307637
Abstract Introduction Genital herpes (caused primarily by herpes simplex virus 2 [HSV-2]) remains highly prevalent with no licensed vaccine,...
Fibroblasts as Protective Immunoregulators in Oral Mucosal Disease 2310061
Abstract Introduction The oral cavity is a critical barrier site that is continuously exposed to a variety of stimuli, including dietary comp...
Lung Tfh13 Differentiate from Lymph Node-derived Progenitor Tfh Cells to Sustain Allergic Antibody Responses 2266239
Abstract Introduction Allergic inflammation is driven by high-affinity IgE antibody production. We previously reported that during acute alle...
Effects of biological therapy with anti-TNF and anti-IL-12/IL-23 antibodies on parodontitis in patients with inflammatory bowel diseases 2309583
Abstract Introduction The prevalence of periodontitis is elevated in patients with inflammatory bowel disease (IBD). The neutralisation of an...
TLR2 sensing of the SARS-CoV-2 envelope protein drives NLRP3-dependent pyroptosis in post-COVID-19 systemic lupus erythematosus 2300032
Abstract Introduction In systemic lupus erythematosus (SLE), accelerated cell death promotes autoantigen release and immune complex formation...
B Cells Undergo Transcriptional Changes Following Autoimmune Sicca Development in Melanoma Patients Treated with Immune Checkpoint Inhibitors 2256997
Abstract Introduction Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of melanoma and other cancers but can cause...
CD36-mediated metabolic changes in Tbet+CD11c+ B cell during obesity 2309773
Abstract Introduction CD21- CD23- CD11c+ Tbet+ B cells expand in primary immune and peripheral tissues during chronic conditions such as agin...
SLC7A5-mediated glutamine export is required for humoral immunity 2308652
Abstract Introduction Germinal center (GC) B cells and plasma cells strongly upregulate gene expression of SLC7A5, which is an amino acid ant...