The Journal of Immunology
Articles in this Issue
ExTh17 Cells Arising from Th17 Support Chronic RA-Like Inflammation Independent of IL-17 2260860
Abstract Introduction T helper 17 (Th17) cells are present in both peripheral blood and synovial fluid of patients with rheumatoid arthritis...
Membrane Shedding Through T Cell Microvilli Enhances Clonal Expansion via mTOR Pathway Activation 2266804
Abstract Introduction When T cells establish an immunological synapse with antigen-presenting cells (APCs), they release surface membrane fra...
Genetic Depletion of Tumor-cell Derived Complement Factor H Suppresses Glioblastoma Development 2334891
Abstract Introduction Complement factor H (CFH) is a pivotal inhibitory modulator in complement alternative activation pathway. Our previous...
Δ8-Tetrahydrocannabinol (Δ8-THC) attenuates LPS-induced acute respiratory distress syndrome (ARDS) through immune-endothelial reprogramming 2300199
Abstract Introduction Acute Respiratory Distress Syndrome (ARDS) is a severe inflammatory lung disorder associated with high mortality. Curre...
Antibody Recruiting Small Molecules as Immune Probes 2254059
Abstract Introduction Immunotherapies that enhance the immune response may offer a novel approach for eliminating mycobacteria infections. Ou...
Itaconate alleviates autoimmune uveitis by boosting FOXP3 and blocking succinate-driven inflammation 2309786
Abstract Introduction We recently reported the activation of the Irg1/itaconate axis in promoting inflammation resolution during ocular infec...
Glycolysis Dependence of Lupus Antigen-Specific B cells Linked to Mitochondrial Dysfunction and Age-associated B Cell Differentiation 2309226
Abstract Introduction Different metabolic requirements between autoreactive and non-autoreactive B cells are potential targets of therapeutic...
Macrophage Priming Against Glyco-Antigens in the Host Microbiome 2260858
Abstract Introduction The mammalian immune system recognizes and responds to a broad variety of glycan antigens, most notoriously including l...
Antigen clade matching enhances protective efficacy of H5N1 DNA vaccines delivered by electroporation or lipid nanoparticles 2267127
Abstract Introduction Highly pathogenic avian influenza viruses (HPAIs) continue to threaten both agriculture and human health. Recent H5N1 c...
Immunotherapy Resistant Triple Negative Breast Cancer Utilizes Interferon Gamma Signaling to Evade NK Responses during Metastasis 2335047
Abstract Introduction Combination immunotherapy is an approved treatment for stage II-III triple negative breast cancer (TNBC). However, part...
Unmasking the in vivo role of IGF1R in Chronic lymphocytic leukemia and identifying novel inhibitors for its function 2298900
Abstract Introduction Insulin-like growth factor 1 receptor (IGF1R) signaling is a key regulator of cellular anabolism and is critically impl...
Oncostatin M Limits Lung Injury during Influenza by Modulating Leukocyte Recruitment and Inducing Tissue Repair Factors 2258236
Abstract Introduction Oncostatin M (OSM), an IL-6 family cytokine, is upregulated during pneumonia. We and others have previously shown that...
Functional Identification and Characterization of Human Tissue Resident Memory T Cells Using Ex Vivo Lung Perfusion 2309862
Abstract Introduction Identifying tissue resident memory T cells (TRM) in human lungs has traditionally relied on imprecise surrogate markers...
IFN-γ shapes neutrophil function and lung host defense against Aspergillus fumigatus 2220821
Abstract Introduction Aspergillus fumigatus (Af), a ubiquitous airborne fungus, causes >90% of invasive aspergillosis (IA). While tria...
Tissue tuned cell death: harnessing death for therapeutic efficacy 2260883
Abstract Introduction Immune cell death programs are not passive endpoints but active regulators of tissue immunity. Neutrophil extracellular...
Fever temperature alters metabolic and cytokine activities in activated macrophages in mice, chickens and fish 2266416
Abstract Introduction Response to fever affects the biological process in animals and often they are conserved in animals. In this study we i...
Spatially Resolved High-Plex Protein Profiling of Immune States in FFPE Tissue 2334779
Abstract Introduction Understanding immune cell states and signaling within intact tissue architecture remains a central challenge in immunol...
The VISTA—LRIG1 Axis Integrates Myeloid and T Cell Suppression to Drive Immune Resistance in Triple-Negative Breast Cancer 2303786
Abstract Introduction VISTA is a myeloid-enriched inhibitory ligand strongly linked to poor therapeutic outcomes in triple-negative breast ca...
Breast milk-derived signals regulate epithelial cells maturation and γδ-IEL colonization to shape early life intestinal homeostasis 2258727
Abstract Introduction The intestinal epithelium is a specialized barrier that balances tolerance and defense against luminal antigens and mic...
Powering health literacy with STEAM: Using an infographic project to teach the public about complex topics in immunology 2265691
Abstract Introduction An infographic is a brief document that emphasizes the use of charts, figures, or diagrams to graphically represent inf...
Expanded IL-22 producing γδ T cells after neonatal respiratory viral infection are required for lung repair 2241785
Abstract Introduction Human metapneumovirus (HMPV) is a respiratory virus that can lead to lower respiratory tract infection (LRTI), causing...
Effects of the Antiretroviral Raltegravir on Amyloid-Beta1-42-Induced Neuroinflammation 2310253
Abstract Introduction There is growing evidence supporting the potential role of microbial infections in the aetiology of Alzheimer’s disease...
MAIT17 Cells and IL-17-Driven iBALT Formation Protect Against Pulmonary Tularemia 2267799
Abstract Introduction Here we demonstrate that respiratory infection with Francisella tularensis induces the formation of induced bronchus-as...
Scaling measurements of peptide-HLA complex stability using user-defined libraries and mass spectrometry 2310029
Abstract Introduction Human leukocyte antigen (HLA) class I presents intracellular peptides to the immune system on the cell surface. Since t...
Role of EHF in regulating B cell checkpoint molecule TIM-1 and development of CD11c+TIM-1+ Age-associated B cells 2301855
Abstract Introduction Aging is associated with an increased risk of cancer and immunosenescence, coinciding with the expansion of Age-associa...