The Journal of Immunology
Articles in this Issue
The Enteric Nervous System Primes Systemic Immunity in Response to Mucosal Infection 2258662
Abstract Introduction The enteric nervous system (ENS) is essential for gastrointestinal (GI) function and has recently been implicated in re...
Loss of TET function in T regulatory cells yields Tfh-like ex-Treg cells with the features of heterochromatin dysfunction 2266533
Abstract Introduction FOXP3 is the lineage-defining factor of T regulatory (Treg) cells, which can lose FOXP3 and convert into pathogenic ex-...
TRIM21 Orchestrates Inflammasome Assembly and Drives Autoinflammatory Pathology 2300561
Abstract Introduction Inflammasomes are pivotal cytoplasmic scaffolds that drive the maturation of interleukin (IL)-1β and IL-18 and initiate...
Exploring Female Obesity and Type 1 Interferon Signaling in the Context of Multiple Sclerosis 2310319
Abstract Introduction Multiple sclerosis (MS) is a demyelinating autoimmune disease that is heterogeneous in prognosis. This variability is e...
Type 1 interferons (T1 IFNs) regulate cellular redox balance by suppressing the host antioxidant response during influenza A virus infection in vivo 2267523
Abstract Introduction Influenza A virus (IAV) infection leads to a wide spectrum of outcomes, from asymptomatic cases to severe disease, emph...
Targeting MDSC activation via the RAGE/TLR4 pathway during early TB modestly reduces lung inflammation but not granuloma bacteria loads 2310052
Abstract Introduction Tuberculosis (TB) causes more than a million deaths annually. Drug-sensitive TB is treated with an arduous antibiotic r...
Development & clinical validation of microneutralization assays for the robust quantification of neutralizing antibodies to human cytomegalovirus 2305514
Abstract Introduction mRNA-1647 is an investigational vaccine composed of six mRNAs encoding human cytomegalovirus (hCMV) gB and pentamer ant...
Collaboration among the common gamma chain cytokine family supports circulating and tissue-resident CD8+ T cell memory 2259059
Abstract Introduction We recently demonstrated resilience of circulating and tissue-resident memory (TRM) CD8+ T cells to loss of interleukin...
B cell-intrinsic CCR6 expression is required for IgE production in a murine model of galactose-alpha-1,3-galactose syndrome 2267251
Abstract Introduction Alpha-gal syndrome (AGS) is acquired through bites from the lone star tick (LST), leading to IgE-mediated reactions to...
Elucidating the Function of Redox-Signaling Mechanisms Underlying Trained Immunity in Alveolar Macrophages 2303944
Abstract Introduction Trained immunity represents a functional state of the innate immune system characterized by long-term epigenetic and me...
Prolonged IL-10 Exposure Modulates Adaptive and Innate Immune Responses in Secondary Lymphoid Organs during Experimental Autoimmune Encephalomyelitis 2332777
Abstract Introduction Interleukin-10 (IL-10) is a potent immunoregulatory cytokine that suppresses pro-inflammatory cytokine production, redu...
Targeting genome organizer Satb1 in regulatory T cells safely and potently enhances cancer immunity 2309560
Abstract Introduction Rigorous research over the years has revealed that the cellular composition of the tumor microenvironment (TME) matters...
Tissue-Resident Memory B cells Mediate Local and Metastatic anti-Cancer Immunity 2310347
Abstract Introduction Tissue-resident memory B cells (BRM) have been identified in barrier tissues such as the lung, where they provide durab...
Early-life mucosal T cells direct intestinal stem cell fate via a coordinated developmental program 2305986
Abstract Introduction Although early-life immunity was once considered immature, the human fetal immune system is dynamic and compartmentaliz...
Endogenous Retrovirus Neoantigen Enables Personalized Cancer Vaccine in glioblastoma, IDH-wildtype 2259068
Abstract Introduction Glioblastoma (GBM) remains refractory to immunotherapy due to low mutational burden and limited neoantigens. Aberrant e...
Diet-Specific Microbial Rewiring Governs Immune Activation Across the Gut—Liver—Kidney Axis in Experimental MASLD 2303975
Abstract Introduction Metabolic dysfunction—associated steatotic liver disease (MASLD) often advances beyond hepatosteatosis to systemic immu...
Using hand drawings as a visual learning tool to encourage medical students’ understanding of complex contents of innate and adaptive immune responses 2304682
Abstract Introduction Understanding how the innate and adaptive immune systems work to protect the body from infectious diseases, cancer, or...
Loss of STAT1 and Nitric Oxide Signaling Compromises the Development of the Stress Erythropoiesis Niche 2260816
Abstract Introduction Steady-state erythropoiesis generates erythrocytes in the bone marrow to replace senescent cells cleared by the spleen....
Mucosal cellular immunology in SARS CoV2 infection and hybrid immunity 2309658
Abstract Introduction Mucosal immunity is critical in protection against COVID-19 respiratory disease. It is still unclear how the dynamics a...
The in vivo inhibitory fucntion of the MHC-I a3 domain/CD8a interaction 2329318
Abstract Introduction Since the discovery of the MHC-I α3 domain/CD8α interaction approximately 40 years ago, numerous in vitro studies have...
Oxphos, not Glycolysis, Promotes the Survival Of Effector Tc17 Cells 2307301
Abstract Introduction IL-17A+ T cells are implicated in immunity and immunopathology. Fungal infections primarily occur in immunocompromised...
IL-39/IL-39R Signaling Drives Acute Graft-versus-Host Disease by Promoting Pathogenic T-Cell Responses 2259690
Abstract Introduction Acute graft-versus-host disease (aGVHD) remains a life-threatening complication of allogeneic hematopoietic cell transp...
Milk Allergen-Induced Eosinophil Activation in Eosinophilic Esophagitis: The IgG4 Pathway 2302520
Abstract Introduction Eosinophilic esophagitis (EoE) is a chronic allergic condition, defined by symptoms of esophageal dysfunction (such as...
Dual Immunomodulatory Roles of MARCKS in Proinflammatory and Type I Interferon Signaling in Macrophages 2306298
Abstract Introduction Lipopolysaccharide (LPS) signaling plays a critical role in innate immune responses and inflammation. Myristoylated ala...
Caught in the NET: Stress-Driven Neutrophil Dynamics Alter Behavior 2258480
Abstract Introduction Despite recognized neuroendocrine-immune crosstalk, the effects of psychological stress on neutrophil extracellular tra...