The Journal of Immunology
Articles in this Issue
Human gut microbe, Parabacteroides distasonis, accelerates diabetes onset in mice without causing gut dysbiosis 2258225
Abstract Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the destruction of pancreatic, insulin-producing...
Succinate Fuels CCR4+ Treg Expansion and Immune Escape in Aging Ovarian Tumors 2256159
Abstract Introduction Ovarian cancer (OvCa) remains the most lethal gynecologic malignancy, with older women experiencing the poorest outcome...
Early establishment of Virtual memory T cells in the neonatal lung 2259596
Abstract Introduction CD8+ T virtual memory (TVM) cells are antigen-inexperienced, memory-like cells that arise early in life. To date, most...
AHR-activated Stab1+Ly6G+ macrophages elicit resolution of pulmonary fibrosis-associated pathology 2328474
Abstract Introduction In response to various inflammatory stimuli, bone marrow-derived macrophages replace tissue-resident macrophages and me...
MEK/ERK Mediated Diffuse Alveolar Hemorrhage in Murine Lupus 2261092
Abstract Introduction About 3% of patients with lupus develop severe diffuse alveolar hemorrhage (DAH) with pulmonary vasculitis. C57BL/6 (B6...
Myeloid—Vascular Crosstalk as a Regulator of Secondary Brain Injury After Stroke 2310349
Abstract Introduction Secondary brain injury after stroke is a major factor in neurological outcomes, yet the mechanisms behind it remain poo...
Advanced Machine Learning Across Multiple Vaccines to Predict Durable Immunogenicity using the Immune Signatures Data Resource 2260430
Abstract Introduction Understanding vaccine durability is key to designing immunizations with long-term efficacy. Leveraging the Immune Signa...
Targeting IL-22 activity to the gut epithelium confers disease benefit without provoking skin inflammation 2258200
Abstract Introduction IL-22 is a cytokine acting on surface-lining epithelial cells to induce antimicrobial defense and barrier regeneration....
A Hybrid Grading Model for Immunology Education: Balancing Rigor and Equity 2256290
Abstract Introduction Immunology, a field known for its complexity and clinical significance, often imposes high cognitive and emotional dema...
Mapping the chromatin landscape of the mouse immune system with low-input automated CUT&RUN 2260000
Abstract Introduction Understanding how immune cells develop and function requires insight into the epigenomic mechanisms that regulate gene...
Evaluating immunotherapy response in bladder cancer patients by spatially interrogating PD-1/PD-L1 interaction 2258170
Abstract Introduction Protein-protein interaction is one of the many mechanisms where individual cells communicate with nearby cells or extra...
De novo generation of innate memory-like T cells occur early during human immune development 2254150
Abstract Introduction Infants rely heavily on innate immunity while adaptive memory develops. A subset of T cells, termed “virtual memory” or...
Monocyte-Derived ADA2 Regulates Myeloid—T Cell Crosstalk and Drives Pro-Inflammatory Responses Linked with Intestinal Inflammation in Crohn’s Disease 2307789
Abstract Introduction Crohn’s disease (CD) is a chronic inflammatory disorder marked by dysregulated immune responses. Purinergic signaling c...
Unbiased Multiparameter Analyses Reveal Mechanisms of Variable Restimulation-Induced Cell Death Sensitivity across Human T cell Populations 2251586
Abstract Introduction Restimulation-Induced Cell Death (RICD) is a crucial self-regulatory apoptosis pathway that constrains effector T cell...
IgA is necessary and sufficient to protect against norovirus infection 2258197
Abstract Introduction Human norovirus (HNV) causes up to 700 million infections and 200,000 deaths each year, primarily affecting young child...
Organ-scale control of persistent, host-destructive T cell responses following infection 2256259
Abstract Introduction The mammalian immune system deploys potent inflammatory responses to defend host tissues from invading pathogens, but t...
Repeated brain resident memory T cell reactivation induces microglial and T cell remodeling and sustained microglia activation in Alzheimer’s disease 2259954
Abstract Introduction Resident memory T cells (TRM) are a subset of memory T cells that persist in lymphoid and non-lymphoid tissues. Brain T...
Combination XPO1/PD1 inhibition for canine cutaneous T cell lymphoma: a comparative oncology approach 2258208
Abstract Introduction Cutaneous T cell lymphoma (CTCL) is a rare non-Hodgkin lymphoma marked by malignant T cell infiltration of the skin, wh...
An integrated cell atlas of the innate lymphoid cells in health and disease 2255047
Abstract Introduction Innate lymphoid cells (ILCs) represent a highly diverse family of lymphocytes that play pivotal roles in tissue homeost...
T-bet—dependent CD4+ T cell effector programming is essential for chronic resistance to Toxoplasma gondii 2308788
Abstract Introduction Protective immunity to the intracellular parasite Toxoplasma gondii relies on a rapid and robust CD4+ Th1 effector resp...
Development and Validation of High Sensitivity SimpleStep Ignite® ELISAs for Quantitative Measurement of Human Immune Checkpoint Proteins 2333298
Abstract Introduction Immune checkpoint pathways play critical roles in regulating T cell activation, tumor immune evasion, and responses to...
Butyrate and Secondary Bile Acids-Producing Gut Microbes Suppress Insulitis in NOD Mice 2258407
Abstract Introduction Gut microbiota-derived metabolites, including short-chain fatty acids (SCFAs) such as butyrate and secondary bile acids...
Engagement of the T cell receptor against an oncolytic virus generates a population of hypereffector CAR T cells with potent antitumor activity 2256915
Abstract Introduction We have shown that combining CAR T cells with oncolytic viruses (OVs) generates a subpopulation of highly cytotoxic CAR...
Epigenetic reprogramming of terminal T cell differentiation via DNMT1 inhibition reverses terminal DNA methylation and enhances multipotency 2259880
Abstract Introduction The effectiveness of T cell-based immunotherapy is limited due to T cell exhaustion, a state of impaired cytotoxicity,...
Cisplatin presentation to CD4 T cells involves robust activation and immunotoxicity 2258176
Abstract Introduction Cisplatin, a platinum-based chemotherapeutic agent, remains one of the most efficacious drugs in the clinical managemen...