The Journal of Immunology
Articles in this Issue
Synthetic Sufficiency Models of Cell Death for Immunology 2260195
Abstract Introduction Regulated cell death is essential for tissue homeostasis and host defense. Many death pathways culminate in the loss of...
The transcription co-regulator OCA-B/Pou2af1 differentially controls autoimmunity and tumor immunity 2307240
Abstract Introduction Expression of the transcription coregulator OCA-B in T cells is dispensable for primary immune responses but critical f...
A Novel Dual-targeting OX40L and IL-13 Bispecific Antibody with Synergistic Effect for Atopic Dermatitis Treatment 2255160
Abstract Introduction Atopic dermatitis (AD) is a chronic inflammatory skin disorder. While the immune response in AD is predominantly mediat...
MHC-II-restricted neoantigen expression drives tumor infiltration, activation, and maintenance of nonspecific T cells in lung cancer 2251169
Abstract Introduction Cancer mutations can result in the expression of tumor-specific “neoantigens” that are targeted by T cells. Neoantigen...
Host Lipid and Mitochondrial Metabolism Networks as Functional Targets for Novel Antimicrobials against Intracellular Bacteria 2309839
Abstract Introduction Host lipid metabolism has been implicated in viral and bacterial pathogenesis. Here we identify that temporal manipulat...
Shield or Showcase: Unraveling How BCR Binding Shapes MHCII Peptide Presentation for CD4+ T Cell Activation 2256684
Abstract Introduction Effective cooperation between B cells and CD4+ T cells is central to durable antibody responses. This interaction is me...
The antigen-specific immunotherapy, AKS-107, selectively depletes anti-insulin B lymphocytes in the pancreas and reduces insulitis in T1D-prone mice 2259549
Abstract Introduction Type 1 diabetes (T1D), results from T cell-mediated destruction of insulin-producing beta cells. Developing new immunot...
B-Cell Tolerance Checkpoint Fidelity in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) 2259996
Abstract Introduction Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder of the...
Immunotherapeutic control of MHC I-heterogeneous tumors to minimize therapy resistance 2307892
Abstract Introduction The anti-tumor activity of CD8 T cells, which recognize MHC I-presented tumor antigens, is enhanced by blocking checkpo...
Targeting convergent pathways prevents the differentiation of tissue-resident memory T cells from multilineage progenitors in the arthritic synovium 2256215
Abstract Introduction Rheumatoid arthritis is an autoimmune disease characterized by chronic, recurrent inflammation of the joints. We identi...
Single-cell and spatial transcriptome profiling reveals innate-adaptive crosstalk in alopecia areata 2251484
Abstract Introduction Alopecia areata (AA) is an autoimmune disorder characterized by immune-mediated attack on hair follicles, resulting in...
Microglial Remodeling of Cerebrovascular Structure and Function during Respiratory Inflammation 2310075
Abstract Introduction Microglia are brain-resident immune cells that have valence on virtually all areas of the cerebral landscape, one locus...
Aging releases the brakes on the T follicular helper cell — B cell axis in murine atherosclerosis 2256916
Abstract Introduction Aging is the most dominant risk factor for atherosclerotic cardiovascular disease (ASCVD), which is characterized by th...
Optimized arenavirus vectors with tumor-tropic mutations as new class of amplificators of anti-tumoral T cell responses 2259607
Abstract Introduction Recent understandings of anti-tumoral immune mechanisms reveal a critical role for strong and sustainable activation of...
People living with HIV have increased CD4+ T cell metabolic activity and reduced influenza-reactive cellular responses to vaccination 2260148
Abstract Introduction While antiretroviral therapy has improved health outcomes for people living with HIV (PLWH), individuals are more likel...
Decoding Single-Cell Protein Interactomes with the Proximity Network Assay 2309978
Abstract Introduction Proteins on the cell surface do not act in isolation, rather, their spatial organization and physical interactions are...
Aging Narrows Human B1-like Cell Repertoire and Impairs Defense Against Encapsulated Pathogens 2256562
Abstract Introduction B1-like B cells are an innate-like subset of human B cells that produce natural antibodies essential for early defense...
Host Immune Composition Complexity Shape Murine IFN-γ ELISpot Readouts 2251432
Abstract Introduction ELISpot enables highly sensitive counting of cytokine-secreting cells at single-cell resolution; however, it remains un...
Immune checkpoint blockade enhances CD4 effector function and enables control of persistent viral infection 2310195
Abstract Introduction T cell exhaustion, a defining hallmark of chronic viral infections and cancer, is characterized by the progressive loss...
CD40+ MHC-II+ astrocytes promote Th17 cell-driven CNS autoimmunity 2257206
Abstract Introduction Astrocyte subsets contribute to the pathology of multiple neurologic disorders, including the T cell driven autoimmune...
Expanding the Antigen Targeting of CAR T Cells via a Universal Bispecific T cell Engager 2259699
Abstract Introduction Although CAR T cell therapy has shown remarkable clinical effects in the treatment of hematological cancers, the applic...
An allogeneic CD19 targeted Engineered Treg approach for treating B cell mediated autoimmune diseases 2260315
Abstract Introduction CD19 CAR T cells have demonstrated promising efficacy in SLE by deeply depleting B cells, but these autologous cell the...
Nuclear estrogen receptors modulate regulatory T cell suppressive function 2309981
Abstract Introduction Autoimmune diseases are driven by an intricate combination of genetic and epigenetic factors, but the specific mechanis...
GLUT1 in Memory CD4+ T-cells Correlates with Sustained Antibody Responses and Polyfunctionality Post-RSV Vaccination in Immunocompromised Individuals 2250589
Abstract Introduction The immunogenicity of respiratory syncytial virus (RSV) vaccination in immunocompromised individuals is poorly understo...
Treatment Responses Alter Myeloid Activation in BRAF-Mutant Melanoma 2252856
Abstract Introduction Melanoma is responsible for 80% of skin cancer-related deaths. Approximately 50% of melanoma patients carry the BRAFV60...