The Journal of Immunology
Articles in this Issue
Imprinted antibody lineages can persist for half a century and dominate cross-neutralizing recall responses to poliovirus 2310306
Abstract Introduction Humoral immunity depends on a dynamic interplay between durable, circulating polyclonal IgG antibodies and long-lived m...
Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation 2253320
Abstract Introduction The border between chronic inflammation and autoimmunity is obscure. It is unclear whether persistent innate immune act...
Rapid Identification of Aerobic Growth in Sepsis Pathogens by Flow Cytometry 2254627
Abstract Introduction Sepsis is a life-threatening syndrome with 30% mortality in severe cases. Early therapy within 6 hours improves prognos...
The Ikaros zinc finger transcription factor Aiolos promotes the formation of lung-resident memory CD8+ T cells 2257320
Abstract Introduction Influenza A virus (IAV) is responsible for half of all pandemics since the early 1900s, and since 2024, influenza infec...
Long-term maintenance of CD8+ tissue resident memory T cells in the upper respiratory tract 2257745
Abstract Introduction CD8+ tissue-resident memory T cells (TRM) in the upper respiratory tract (URT) limit viral replication and prevent spre...
A neonatal bias towards CX3CR1 ++ memory CD8+ T cells is associated with impaired control of Cytomegalovirus in early life 2232221
Abstract Introduction Congenital cytomegalovirus (CMV) is a leading cause of hearing loss and neurological deficits. A risk factor for congen...
Targeting the Idiotype: Nanobody-Based PET Imaging of Antigen-Specific T Cells in Experimental Autoimmune Encephalomyelitis 2260726
Abstract Introduction Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by demyelination and neuro...
LatY136F mice: a preclinical model for IgG4-related disease and autoimmune disorders 2328676
Abstract Introduction Experimental preclinical models are powerful research tools to explore autoimmune diseases as well as the efficacy and...
Immunomodulatory effects of non-psychoactive cannabinoids in a model of metabolic dysfunction-associated steatotic liver disease (MASLD) 2232983
Abstract Introduction Emerging evidence suggests that activation of different immune cell populations contributes to the progression of MASLD...
BCG vaccine induced CD4 T cell activation is dependent on processing by cDC1 and cDC2 subsets of human dendritic cells 2259597
Abstract Introduction Tuberculosis due to Mycobacterium tuberculosis (Mtb) kills a million people each year and the widely used BCG vaccine i...
Enhanced CD25 expression and IL-2/STAT5 signaling characterize β-galactosidase+ senescent and aged CD4+ T cells 2257543
Abstract Introduction Alterations to the IL-2 signaling axis contribute to age-related immune decline, with increased IL-2RA (CD25) expressio...
Differential effect of Recombinant Zoster Vaccine (RZV) and Zoster Vaccine Live (ZVL) in a controlled human infection model (CHIM) of VZV reactivation 2307815
Abstract Introduction HZ results from uncontrolled VZV reactivation. Both ZVL and RZV protect against HZ, with RZV (AS01B-adjuvanted gE glyco...
Characterization of Non-Neutralizing Antibody Responses in a Dengue Virus-4 Human Challenge Model 2243013
Abstract Introduction Primary infection with one of the four dengue viruses (DENV-1—4) induces serotype-specific antibodies (Abs) that confer...
Carbonic anhydrase 1 is a potent therapeutic target for mucosal and connective tissue mast cells 2261031
Abstract Introduction Mast cells (MCs) are innate immune cells that play an important role in mediating allergic and inflammatory responses....
Facile Induction of Immune Tolerance by an Interleukin-2-TGF-β Surrogate Agonist 2329867
Abstract Introduction CD4+ regulatory T (Treg) cells are essential for immune tolerance. Peripherally induced Tregs (pTregs) complement thymi...
B Cells Reside in the Healthy Murine Retina and are Altered by Lack of IgM 2245387
Abstract Introduction The retina, the central nervous tissue responsible for vision, undergoes functional decline with aging contributing to...
Molecular Insights into the RELT—FLNA Interaction and its Role in Breast Cancer Cells 2259610
Abstract Introduction Receptor Expressed in Lymphoid Tissues (RELT), member of the Tumor Necrosis Factor Receptor Superfamily, is upregulated...
Microbiota-dependent IGF-1 limits alveolar macrophage inflammatory function 2257596
Abstract Introduction The impact of the systemic commensal microbiome on the lung microenvironment and alveolar macrophage (AM) polarization...
Evaluating the Immune Response to the Artificial Oxygen Carrier OxyVita® 2308574
Abstract Introduction A major challenge in treating uncontrolled blood loss through hemorrhage is the lack of an oxygen delivery system to su...
Influenza-specific lung-resident memory B cells assist CD4 recall responses during challenge infections 2256984
Abstract Introduction In repeated influenza A virus (IAV) infections, lung-resident memory B cells (BRMs) enhance early recall responses. How...
Single-cell RNA sequencing reveals conserved T cell populations across kidney tissue and urine of patients with immune checkpoint inhibitor nephritis 2262974
Abstract Introduction Immune checkpoint inhibitors inhibit the negative regulation of T cells, leading to both anti-tumor activity and immune...
The Immunological Landscape of Biliary Atresia: Focus on Th2 and Th17 Profiles 2330296
Abstract Introduction Our understanding of the underlying causes and immunological mechanisms of biliary atresia remains limited. Hence, the...
Germline-encoded recognition underlies development of convergent antibodies in humans 2246040
Abstract Introduction The presence of food-specific IgG in response to dietary ingestion has been long-observed. In a subset of individuals,...
Distinct Innate Immune Correlations to Tissue-Resident Memory T Cell Distribution across the Female Reproductive Tract 2259843
Abstract Introduction Tissue resident memory T cells (TRM) positioned within immune-restricted tissue sites, including the female reproductiv...
Defects in CD8+ T cell suppression by Foxp3-dE2 regulatory T cells 2257749
Abstract Introduction Regulatory T-cells (Tregs) prevent autoimmunity through suppressive functions which are largely programmed by the trans...