The Journal of Immunology
Articles in this Issue
Reconstitution of human bronchial epithelial cells in humanized mice with autologous immune system 2335217
Abstract Introduction Humanized mouse models were developed to bridge fundamental differences between murine and human immune systems and to...
Inflammasome Activation Limits Radiotherapy-Induced Antitumor Immunity and Shapes CD8+ Responses in a Sex-Dependent Manner 2260523
Abstract Introduction Radiation therapy (RT) induces immunogenic cell death and antitumor immunity. We demonstrated that myeloid MyD88 signal...
Monoclonal antibody therapy promotes survival by recalibrating neuroinflammation during Australian Bat Lyssavirus Infection 2308563
Abstract Introduction Australian Bat Lyssavirus (ABLV), a neurotropic relative of Rabies virus, causes fatal encephalitis. Effective treatmen...
Characterization of myelin lipid changes across disease stages in experimental autoimmune encephalomyelitis 2302268
Abstract Introduction Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. The myelin sheath of the...
Impact of Epstein-Barr Virus LMP2A on Toll-Like Receptor 9 (TLR9) expression and function 2257860
Abstract Introduction Toll-like receptor 9 (TLR9) in an important mechanism by which both innate and adaptive immune cells sense unmethylated...
CD2 x IL2RG bispecific antibodies synergistically modulate lymphocyte activation, resulting in suppression of inflammation and prevention of GVHD 2258985
Abstract Introduction The common γ chain (γc, IL2RG) is a shared receptor subunit for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 that regulates...
Between Nodes and Niches: Tracing Tumor-Associated B Cell Trafficking and Effector Maturation in NSCLC 2260893
Abstract Introduction B cells support anti-tumor immunity via antibody production, antigen presentation, and immunomodulation. Somatic hyperm...
Spatial and vascular determinants of tumor-infiltrating lymphocyte expansion in glioblastoma 2260218
Abstract Introduction Adoptive transfer of tumor-infiltrating lymphocytes (TILs) has shown promise in solid tumors but remains limited in gli...
Targeting Myeloid-Derived Suppressor Cell-Mediated Immunotherapy Resistance in Pediatric Brain Cancer 2260592
Abstract Introduction Despite the decrease in childhood cancer mortality, a cure for certain tumors remains elusive. The survival rates for h...
Gut Microbial Translocation may drive NK cell Reprogramming in Adolescents Living with Perinatally Acquired HIV 2308891
Abstract Introduction Natural killer (NK) cell dysregulation contributes to chronic inflammation in people living with HIV, yet underlying me...
Exocyst complex regulates fungal-mediated IL-33 release and facilitates type 2 immune response 2304790
Abstract Introduction Recent studies overwhelmingly show that the fungal microbiome (mycobiome) is pervasive in tumors and plays a key role i...
Influence of the absence of TRPM5 in CD4 T cells during the inflammatory response in autoimmune colitis induced by adoptive cell transfer 2258085
Abstract Introduction Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, with an increased in...
Age and Activity-Dependent Differences in Intraocular Immune Profile of Chronic Autoimmune Uveitis 2259109
Abstract Introduction Autoimmune uveitis is a chronic inflammatory disorder of the eye. Uveitis relapse occurs in 85% of patients who discont...
The Ubiquitin Ligase Marchf1 Controls cDC Development to Sustain CD8+ T Cell Antitumor Immunity and Response Checkpoint Blockade 2259196
Abstract Introduction Conventional dendritic cells (cDCs) are essential for sustaining CD8+ T cell-mediated tumor immunity, yet the developme...
Assessment of Transcription Factors and Cytokines of CD4+ T Cells in beta2-Adrenergic Receptor Deficient Stressed Mice during Chlamydia Infection 2260245
Abstract Introduction Genital infection by Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. However...
Post-operative IL-15 enhances the immunosuppressive effects of myeloid derived suppressor cells in sarcoma 2258326
Abstract Introduction Myeloid derived suppressor cells (MDSCs) inhibit NK and T cells leading to negative outcomes in cancer. Interleukin 15...
Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease 2309590
Abstract Introduction Alcohol is a leading cause of global morbidity and mortality, yet the innate immune sensors that detect alcohol-induced...
Evaluation of Vesiculab Vesi-Ref CD63- mNeonGreen (mNG) Extracellular Vesicles (EV) Reference Standard on the CytoFLEX nano Flow Cytometer 2306506
Abstract Introduction Accurate and reproducible characterization of EVs by nanoscale flow cytometry requires both robust reference materials...
Il22 regulatory elements shape inflammatory responses in Imiquimod-induced psoriasis 2258410
Abstract Introduction IL22 is a type III cytokine produced by innate and adaptive lymphocytes that is essential for maintaining tissue homeos...
Integrated Multi-Omic Approach Using Spatial Transcriptomics and Proteomics Reveals an In-Depth View of Localized Immune Response in Renal Cancer 2259256
Abstract Introduction Clear cell renal cell carcinoma (ccRCC) is a highly heterogeneous cancer with complex tumor and immune microenvironment...
Identification of microglial immunomodulatory compounds by high-throughput proteomics: insights from quantification of 1000 proteins in > 6,500 samples 2259191
Abstract Introduction Microglia are critical for maintaining neural homeostasis. However, under pathological conditions, they can adopt a chr...
Losing Their Grip: Aging Weakens Treg TCR Catch Bonds Under Force 2260253
Abstract Introduction Aging is associated with a decline in regulatory T cell (Treg) function contributing to the increased severity of autoi...
Identifying Macrophages as Peripheral Transporters of JC Polyomavirus 2258486
Abstract Introduction JC polyomavirus (JCPyV) is a DNA virus that can cause progressive multifocal leukoencephalopathy (PML) upon reactivatio...
Human NK Cell Enrichment and Expansion Using Defined GMP Reagents: Functional and Phenotypic Outcomes 2252995
Abstract Introduction Natural killer (NK) cells are a key component of the innate immune system and chimeric antigen receptor NK cells have s...
A Novel Hybrid Biological-Biomaterial Vector for Antigen Delivery and Human Dendritic Cell Maturation 2306812
Abstract Introduction The use of antigen (Ag) presenting dendritic cells (DC) strategy can prompt effective and personalized anti-tumor immun...