The Journal of Immunology
Articles in this Issue
Chronic lung exposure to Saccharopolyspora rectivirgula leads to a pulmonary fibrotic pattern in mice 2257218
Abstract Introduction Hypersensitivity pneumonitis (HP) is an immune-mediated pulmonary disorder resulting from repeated exposure to environm...
Robust T Cell Activation Kills Tumors Regardless of T Cell Specificity 2260126
Abstract Introduction Solid tumors are populated with functional, non-circulating virus-specific CD8+ T cells, primed for rapid response to r...
Enhancing antibody delivery to the brain using antiviral immune response 2256145
Abstract Introduction Glioblastoma (GBM) is the most aggressive primary brain tumor in adults with an incident rate of 12,000 cases in the Un...
Kindlin-3 splicing variants mark stress granulopoiesis 2261219
Abstract Introduction Mutations in the FERMT3 gene cause Leukocyte Adhesion Deficiency type III (LAD-III), a rare immunodeficiency characteri...
Beyond Memorization: Active and Adult Learning Strategies in Undergraduate Immunology 2241521
Abstract Introduction Learning immunology can be intimidating for undergraduates, but engaging directly with real-world examples can make com...
RORα governs CD8+ T cell memory subset specification and offers a therapeutic node for antiviral immunity 2259080
Abstract Introduction The establishment of immunological memory is crucial for durable antiviral immunity and underlies effective vaccine des...
Shared B cell receptor repertoire signatures across autoimmune diseases from integrated public datasets 2309774
Abstract Introduction Autoimmune disorders arise from aberrant adaptive immune responses against self tissues and affect millions worldwide....
Weight gain and loss increase adipose dendritic cell proportions and antigen presentation 2257389
Abstract Introduction Weight cycling is a growing health concern that has been shown to worsen risk of diabetes beyond that of obesity. Dendr...
Exploring Human NK Cell Function and Activation by Endothelium via P-STAT5 and HuR regulation 2254028
Abstract Introduction Natural killer (NK) cells circulate in the blood in a poised but inactive state and can be further primed by activating...
Identification of antigen-experienced human anti-HER2-specific B cells from peripheral blood 2256237
Abstract Introduction HER2 is a clinically validated oncogenic receptor and therapeutic antibody target; however, the natural occurrence and...
Reprogramming Mesenchymal Plasticity to Restore Thymus Growth and Vascularization 2263454
Abstract Introduction Thymus organogenesis depends on coordinated communication between stromal and hematopoietic cells. We found that thymic...
Modulation of the bone marrow landscape by vaccine adjuvants 2246451
Abstract Introduction Vaccination against influenza virus is currently the best strategy to lessen disease burden. The low immunogenicity of...
Xynapse-T — an antigen-specific scaffold for functional stimulation and expansion of T-cells 2259137
Abstract Introduction Precise and reproducible activation of antigen-specific T cells to evaluate functionality and efficient proliferation o...
Longitudinal Immune Responses to Radiotherapy Differentiate Progression-Free Survival Outcomes in Esophageal Cancer 2309969
Abstract Introduction We hypothesized that baseline immune composition and post-radiotherapy (RT) immune dynamics influence progression-free...
Mural cell-specific deletion of MHC class I antigen presentation increases immune cell infiltration into the brain during neurotropic virus infection 2257679
Abstract Introduction The H-2Db class I restricted CD8 T cell response is critical for clearance of neurotropic Theiler’s virus encephalomyel...
Defining How Iron Metabolism and Cycling Shape the Immune Microenvironment in Synovial Sarcoma 2253974
Abstract Introduction Synovial Sarcoma (SyS) is an aggressive soft tissue sarcoma that is unresponsive to immune checkpoint blockades or adop...
Keratinocyte VISTA suppresses skin IFN-I and inflammatory crosstalk after UV exposure 2256619
Abstract Introduction Ultraviolet (UV) light induces type I interferons (IFN-I) that aid repair but drive pathology when excessive, as in lup...
T cell dysregulation in pediatric obesity 2266671
Abstract Introduction The prevalence of obesity has increased worldwide over the last three decades, including severe obesity increasing amon...
Aging-Associated Nrf2 Loss in Microglia Exacerbates Neuroinflammation and Trained Immunity 2249338
Abstract Introduction Aging is the greatest risk factor for Alzheimer’s disease (AD) and related dementias, with chronic neuroinflammation pl...
Dysregulated IL-33/ST2 axis in hemochromatotic hosts aggravates susceptibility to the Yersinia enterocolitica infection 2259344
Abstract Introduction Iron is essential for host metabolism but becomes toxic in excess, disrupting immune balance. Hemochromatosis (iron ove...
The role of an orphan scavenger receptor (CD163L1) in T cells 2310079
Abstract Introduction It is becoming increasingly clear that the developmental origins of T cells play a major role in their subsequent pheno...
Inhibition of HIV-1 cell-to-cell transmission in-vitro using engineered CAR NK/T cells 2253162
Abstract Introduction Despite the success of antiretroviral therapy in controlling HIV-1 replication, achieving a cure remains a significant...
Host—Microbiota Interactions Fuel Skin Cancer in the Context of TLR4 Deficiency and Epithelial IKKα Reduction 2254771
Abstract Introduction Pattern recognition receptors (PRRs) detect pathogen-associated molecular patterns (PAMPs) maintain epithelial immune b...
Stress-adapted Immunity: The Integrated Stress Response as a Driver of S. aureus Biofilm Persistence 2256775
Abstract Introduction Craniotomy, a neurosurgical procedure for treating brain tumors, epilepsy, and cranial bleeds, carries a 1-5% infection...
Rapid IFNg production by CD8+ TRM slows viral propagation but is insufficient to directly mediate clearance following respiratory virus transmission 2260225
Abstract Introduction Tissue-resident memory CD8+ T cells (TRM) in the respiratory tract can restrict viral spread and protect against transm...