The Journal of Immunology
Articles in this Issue
Ori-TTV particles enable potent in vivo CAR-T cell engineering for the treatment of hematologic malignancies and autoimmune diseases 2256860
Abstract Introduction Chimeric antigen receptor (CAR) T cell therapy has significantly advanced treatment of hematologic malignancies, includ...
A bivalent multi-adjuvant Chlamydia vaccine targeting secreted and outer membrane antigens reduces genital infection and pathology in mice 2257258
Abstract Introduction Chlamydia trachomatis is the most common bacterial STI and a major cause of hydrosalpinx and infertility, making a vacc...
BCMA-CAR Natural Killer Cells Suppress Myeloma in Bone Marrow but Allow Emergence of Extramedullary Disease 2266680
Abstract Introduction Multiple myeloma (MM) is an aggressive blood cancer arising from plasma cells. B cell maturation antigen (BCMA)-targete...
T cell dysfunction during Staphylococcus aureus osteomyelitis in humanized mice 2257659
Abstract Introduction Staphylococcus aureus is the leading cause of implant-associated osteomyelitis. It has a high recurrence rate, a low po...
Effects of an Interactive Response Platform on Learning Outcomes in Medical and Pharmacy Students 2299728
Abstract Introduction Hotspot is an interactive audience response system, powered by PointSolutions technology, that allows students to answe...
Defining the role of Oncostatin M in lung homeostasis 2261154
Abstract Introduction As the primary site of gas exchange, the lung presents a large surface area that is continuously exposed to the externa...
Characterizing the Roles of Dysferlin Deficiency in Function, Polarization, and Secretome of Human iPSC-Derived Macrophages 2251399
Abstract Introduction Limb-girdle muscular dystrophy R2/2B (LGMDR2/2B) is an untreatable and progressive late-onset skeletal muscle disease c...
Mechanisms of CD070, an Active Compound from Chinese Herbal Medicine, in Regulating and Inhibiting PD-1 Expression 2257112
Abstract Introduction PD-1 antibodies have shown clinical success in cancer treatment, but limitations such as limited efficacy, immune-relat...
Colon-Specific Signatures for Tissue Resident Memory T cells in Health and Colorectal Cancer 2258023
Abstract Introduction Tissue-resident memory T cells (TRM) are one of the predominant T cell subsets in the human intestine, yet their role i...
T-ALL Elicits Robust T Cell Responses Despite Low Tumor Mutational Burden in multiple tissues with distinct TMEs 2267295
Abstract Introduction T-cell acute lymphoblastic leukemia (T-ALL) is a devastating pediatric malignancy arising from immature T cells. Despit...
Limited sustainability of regulatory T cell repertoire revealed by novel genetic switches 2257672
Abstract Introduction Regulatory T (Treg) cells carry a diverse T-cell antigen receptor (TCR) repertoire, playing a crucial role in suppressi...
A bacterial immunotherapeutic drives long-term immunity in Glioblastoma 2301770
Abstract Introduction Glioblastoma (GBM) is the most aggressive primary brain tumor, with most patients succumbing to disease within 2 years....
Butyrophilin-like 9 cooperates with JAM-A to drive anti-tumor immunity 2261194
Abstract Introduction Butyrophilin-like 9 (BTNL9), is downregulated across multiple cancer types, including ovarian cancer (OV), its decrease...
Exportin-5 Links miRNA Biogenesis to the Preservation of B Cell Receptor Surface Expression 2310271
Abstract Introduction The B cell receptor (BCR) dictates B lymphocyte identity and function, allowing for a robust adaptive immune response t...
LPS-HDM-Induced Asthma Model: A Translational Platform for Neutrophilic Asthma and Glucocorticoid-Resistant Inflammation 2256839
Abstract Introduction Asthma is a heterogeneous inflammatory airway disease characterized by complex immunopathogenesis. Up to 50% of patient...
The impact of skin-like CD103+ ILC2s on lung immunity 2258463
Abstract Introduction Proper lung function involves tissue-resident immune cells that participate in homeostasis but also protect against fur...
Distinct subsets of tissue-recirculating NK cells revealed by single cell transcriptomic analysis of lymph- and blood-borne cells in sheep 2267560
Abstract Introduction Natural Killer (NK) cells are innate effectors that serve as a first line of defense against viral infections and tumor...
Hallmarks of MHC-restricted T cell receptor repertoires 2257786
Abstract Introduction The αβ T cell receptors (TCR) mature in thymus to functionally recognize MHC-ligands, known as MHC-restriction. Thymic...
Oral Immunization with Maize-Expressed PEDV S1 Antigen Modulates Mucosal Immunity in Weaned Pigs 2304205
Abstract Introduction Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes severe enteric disease in swine, leading to h...
A single cell and spatially resolved atlas of the intestinal innate immune response to infection 2266151
Abstract Introduction Advances in single cell technologies have uncovered novel biology and revealed cellular heterogeneity of complex tissue...
Mitigating Placental Inflammation is Necessary for Improved Fetal Outcomes following Maternal H1N1 Infection 2327794
Abstract Introduction Influenza infection during pregnancy poses significant risks to maternal and fetal health, including increased hospital...
Inflammatory Type 2 Conventional Dendritic Cells Induced by Vaccine Adjuvant Promote Antigen Cross-Presentation through Autophagy Inhibition 2305812
Abstract Introduction Cross-presentation (XPT) is pivotal for inducing antigen (Ag)-specific CD8+ T cell responses, which is linked to better...
Systemic viral infection diversifies neurodegenerative disease progression 2310089
Abstract Introduction Environmental exposures across the lifespan shape the immune landscape and can influence responses to later challenges....
The Autoimmune-Associated PTPN22 Variant Promotes Anti-Tumor Immunity in Melanoma 2310217
Abstract Introduction The autoimmune risk allele of PTPN22, 1858C>T, reduces melanoma risk, but the underlying mechanisms are unclear....
High-throughput TCR-epitope screening using the Jurkat NFAT Reporter-K562 APC cell system on the Microwell ELISpot Platform 2258594
Abstract Introduction Despite the critical role of T-cell receptors (TCRs) in adaptive immunity, experimental validation of predicted cognate...