The Journal of Immunology
Articles in this Issue
Pre-clinical Development of a Novel CAR-T Therapy Targeting TIM-1 for Treating Solid Tumors 2309293
Abstract Introduction Chimeric antigen receptor (CAR)-based therapy represents a major advancement in cancer treatment, especially in hematop...
Erythroid progenitors exhibit non-canonical cellular response to double-stranded DNA 2243743
Abstract Introduction Erythroid cells, like classical immune cells, arise from hematopoietic stem cells, yet their immune potential remains l...
Functional Analysis of GAPDHP65 Suggests a Role in Triple-Negative Breast Cancer Viability 2257990
Abstract Introduction Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options. Dysregulated pseudogene e...
Excess Collagen Accumulation in Microglia-Deficient Rats Mediated by Border-Associated Macrophages 2306686
Abstract Introduction There has been recent interest in investigating microglial dysfunction as a contributor to neurodegenerative conditions...
Oxidative Stress as a Mechanistic Link Between Subclinical Food Allergy and Behavioral Alterations 2334366
Abstract Introduction Mood and cognitive alterations are often reported in individuals with subclinical food allergies who are tolerant of of...
Decoding the role of CD4 T cells in driving autoimmune type 1 diabetes 2333351
Abstract Introduction Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease where CD8 T cells eliminate insulin-producing β cells in...
Characterization of H1N1 and interferon-β-responsive long non-coding RNAs using single-cell CRISPRi in human lung epithelial and immune cell lines 2260688
Abstract Introduction Despite 36,000 long non-coding RNAs (lncRNAs) annotated in the human genome, functional characterization remains limite...
Characterising humoral and airway immunity following Respiratory Syncytial Virus infection challenge in older adults 2309278
Abstract Introduction Respiratory syncytial virus (RSV) is a major cause of respiratory viral illness in older adults, yet the effect of agei...
The membrane distal domain of CD16a shapes the NK cell ADCC immune synapse 2309381
Abstract Introduction Natural Killer (NK) cells are a powerful and versatile part of the human immune system. The molecular mechanisms of the...
Effect of inhibiting pathogen recognition receptor function with small molecules on ovarian cancer cells in vitro 2258086
Abstract Introduction The American Cancer Society estimates that within the year of 2025, around 20,000 women in the USA will receive a diagn...
Targeted Immunotherapy for Regulatory T Cells 2307761
Abstract Introduction Underperformance and dysfunction of CD4+ regulatory T cells (Tregs) has been implicated in the pathogenesis of many aut...
Imprinting of regulatory T cells by gut microbiota early in life 2336688
Abstract Introduction The gut microbiota is essential for immune system maturation in early life. The introduction of solid food at weaning t...
Activating systemic immunity through engineered lymph node-homing T cells 2335174
Abstract Introduction Lymph nodes (LNs) serve as the critical education centers of adaptive immunity to combat pathogens while simultaneously...
Reversing defective priming in tumor-bearing hosts to rescue CD8 T cell function 2260686
Abstract Introduction Tumor-specific CD8 T cells (TST) are often dysfunctional and fail to halt cancer progression. While chronic antigen sti...
The 1000+ mouse project: large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies 2309521
Abstract Introduction Preclinical CAR-T studies often monitor luciferase-labeled tumors in mice to gauge cytotoxicity, but analysis is freque...
Eosinophil—macrophage crosstalk controls obesity-associated adipose inflammation and is stabilized by RELMα in a sex-dependent manner 2309540
Abstract Introduction Eosinophils are immune cells with terminal effector functions in type 2 immune responses, yet recent findings suggest t...
E-cadherin and PD-1 interaction via their N-terminal ectodomains establishes a novel inhibitory axis modulating T cell function 2258851
Abstract Introduction E-cadherin, a member of the cadherin superfamily, is well known for mediating cell-cell adhesion. Recent studies sugges...
Humoral responses in skin inflammation resulted from altered expression of epidermal Blimp-1 2308147
Abstract Introduction The skin epithelium provides both physical and immunological barriers essential for host defense. Our previous study de...
Nrf2 suppresses inflammatory Th1/Th17 responses and promotes regulatory T cell differentiation by CD4+ T cells to alleviate ulcerative colitis 2260871
Abstract Introduction Ulcerative colitis (UC) is a chronic, relapsing form of inflammatory bowel disease (IBD) characterized by inflammation...
Immune Checkpoint Activation Targeting PD-1H (VISTA) Reinforces Human T-Cell Tolerance in Autoimmunity 2335053
Abstract Introduction Immune checkpoints enforce tolerance, while their inhibition boosts antitumor immunity, autoimmunity may benefit from t...
Single-Cell Atlas of Microglia Reveals Conserved and Divergent Cell Populations in Mouse and Human Brain 2255696
Abstract Introduction Microglia are resident immune cells in the central nervous system and a heterogenous population with notable heterogene...
Investigating interferon lambda (IFN-γ) as a novel anti-inflammatory modulator of the skin barrier-immune-microbiome axis in atopic dermatitis 2309532
Abstract Introduction Atopic dermatitis (AD) is a chronic inflammatory skin disease driven by type 2 (Th2)-mediated immune dysregulation, epi...
Association Between Obesity and Asthma Severity: Analysis of NHANES Data 2021—2023 2309566
Abstract Introduction Obesity is a recognized risk factor for asthma severity, but comprehensive population-level data analyses are limited....
Neuroinflammatory Responses in Glial-Immune Interactions to Francisella tularensis in the Central Nervous System microenvironment 2267481
Abstract Introduction Francisella tularensis (Ft), the causative agent of tularemia, is a highly infectious intracellular pathogen and recogn...
NKG2D Supports Long Lived Effector T Cell Function 2308628
Abstract Introduction Memory CD8 T cells display heterogeneity in their phenotype and function. We have described a memory subset of CD8 T ce...