The Journal of Immunology
Articles in this Issue
T6B-mediated inhibition of the miRISC decreases myeloid-derived suppressor cell abundance and enhances survival in a murine ovarian cancer model 2259723
Abstract Introduction MicroRNAs play a critical role in regulating post-transcriptional gene expression. Dysregulation of microRNA concentrat...
Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity 2305382
Abstract Introduction Multiple sclerosis (MS) is an autoimmune disease of the central nervous system driven by genetics and the environment....
Structural characterization of broadly neutralizing and potent V1/V2 apex antibodies elicited in rhesus macaques through immunization 2267435
Abstract Introduction Eliciting broadly neutralizing antibodies (bnAbs) that target the HIV-1 envelope glycoprotein (Env) remains a central g...
Adenosine Suppresses Microglial Immunity in Breast Cancer Brain Metastasis 2306834
Abstract Introduction Breast cancer brain metastasis (BCBM) is a fatal and increasingly common complication in breast cancer patients. The bl...
Therapeutic Efficacy of a Novel Oral NRF2 Activator in a Murine Ulcerative Colitis Model 2256177
Abstract Introduction Ulcerative colitis (UC) arises from three interconnected pathological processes: impaired epithelial barrier function,...
Exploring the origins of adaptive immunity 2257946
Abstract Introduction Jawless vertebrates (Agnathans), such as the sea lamprey, persist today with minimal evolutionary changes compared to t...
Peroxisome proliferator-activated receptor delta loss reduces alloreactive CD4 T cell proliferation and lessens graft-versus-host-disease severity 2260348
Abstract Introduction Our lab previously demonstrated that murine alloreactive T cells increase fatty acid oxidation (FAO) during graft-versu...
The Impact of Environmental Respiratory Hazards on Pulmonary Macrophages 2259898
Abstract Introduction Environmental respiratory hazards (ERH) are associated with pulmonary disease and lung cancer. Yet, the mechanisms by w...
Integrin αV-Mediated Spatially Restricted Activation of Autocrine TGF-β1 Programs Cytotoxic Tissue-Resident NK Cell Differentiation 2310290
Abstract Introduction Tissue-resident natural killer (trNK) cells differentiation requires TGF-β1 for tissue residency. As TGF-β1 often suppr...
Immunomodulatory Tr1 CD4 T cells induced by engineered V1-deleted HIV vaccine candidate decrease the risk of SIV acquisition in macaques 2267572
Abstract Introduction The development of an effective anti-HIV vaccine remains a critical tool to halt the HIV epidemic, particularly due to...
A systematic evaluation of T lymphocytes and metabolic parameters in childhood obesity: new therapeutic targets for the disease? 2308210
Abstract Introduction According to the World Obesity Federation, it is estimated that 206 million children and adolescents aged 5-19 are obes...
T-Cell Activation Reflects the Intersection of Inflammation, Metabolic Dysfunction, and Vascular Risk in Prediabetic Obesity 2256824
Abstract Introduction Chronic low-grade inflammation is a hallmark of obesity and a key driver of metabolic dysfunction and cardiovascular di...
Targeting NRAS-Derived Public Neoantigens in T Cell-Based Cancer Immunotherapy 2261145
Abstract Introduction T cells mediate anti-cancer immune responses through recognition of neoantigens - cancer-specific, mutation-derived pep...
Understanding the intracellular role of IL1α in regulation of immune suppressive myeloid cells in breast cancer 2260588
Abstract Introduction Breast cancer remains one of the most prevalent and deadly malignancies worldwide. The tumor microenvironment (TME) cri...
TGF-β1 can convert hostile NK cells to friendly NK cells via downregulation of an activating receptor and upregulation of inhibitory receptors 2260153
Abstract Introduction In prenatal allotransplantation (Balb/c to C57BL/6), NK cells play a critical role in engraftment or rejection of graft...
A CD19/BCMA Dual-targeting VHH format T-cell Engager with Novel CD3 Binder for Enhanced Potency and Safety Profile 2329221
Abstract Introduction B-cell depletion therapies targeting CD19 or BCMA have shown significant therapeutic potential in systemic lupus erythe...
Uncovering the Elusive Nature of B Lymphocytes and Immunoglobulin in the Central Nervous System during Alzheimer’s Disease 2302553
Abstract Introduction Alzheimer’s Disease (AD) is a fatal, incurable neurodegenerative disease defined by amyloid-beta plaques, tau neurofibr...
Bhlhe40 promotes inflammatory property of ILC2s through differential regulation of IL-10 and GM-CSF expression 2308383
Abstract Introduction ILC2s (group 2 Innate lymphoid cells) are involved in type 2 immune responses during both phases of innate and adaptive...
Characterization of ENU-Induced Mutant Mice Expressing an Alternatively Spliced IL-15 Reveals Defective Antigen Presentation and CD8+ T Cell Immunity 2256931
Abstract Introduction Interleukin-15 (IL-15) is critical for the activation and expansion of CD8+ T cells and dendritic cells (DCs). We inves...
KDM5C-regulated anabolic metabolism is required for T cell expansion 2264712
Abstract Introduction Clonal expansion of T cells is a critical component of the adaptive immune response necessary for combating a diverse r...
The Ufmylation E3 Ligase, UFL1, is Essential for the Development and Functions of Invariant NKT Cells 2260769
Abstract Introduction Invariant natural killer T (iNKT) cells originate from a common lineage with conventional T cells but diverge to become...
Single-cell immunoprofiling of peripheral blood in non-infectious uveitis patients receiving TNF-inhibitors 2260690
Abstract Introduction Although TNF inhibitors (TNFi) are widely used in the treatment of non-infectious uveitis, the mechanisms underlying tr...
A Glucocorticoid-Fas axis controls immune evasion from pan-cytotoxic lymphocytes during metastatic seeding 2334193
Abstract Introduction Metastasis is the major cause of death for patients with solid malignancies, such as Triple Negative Breast Cancer (TNB...
IL-1 signaling directs the prioritization of inflammatory sites in a model of post-operative pulmonary infection 2259548
Abstract Introduction Individuals recovering from surgery are at risk for nosocomial pneumonia. When this occurs, the innate immune system is...
Targeted immunosuppression with a tissue-selective PD-1 agonist prevents rejection of transplanted hearts 2308742
Abstract Introduction Systemic immunosuppression to prevent allograft rejection or treat autoimmune disease can risk infection and malignancy...