The Journal of Immunology
Articles in this Issue
Building Immunity: From LEGO to α-Cells 2321870
Abstract Introduction Legos and immunology are great Methods Le...
De novo pyrimidine synthesis controls lupus-prone germinal center B cell and plasma cell fates 2304696
Abstract Introduction The role of pyrimidine metabolites in SLE-prone germinal center (GC) and plasma cell (PC) responses is unknown....
Senolytic Activities of TLR Agonist Stimulated Mesenchymal Stem Cell Secretome Based Cosmetic GlowSelle™ 2265705
Abstract Introduction Conditioned media of TLR stimulated mesenchymal stem cells (MSC) have been shown to induce various regenerative activit...
Evaluating the Hia adhesin as a potential vaccine antigen against Nontypable Haemophilus influenzae 2309156
Abstract Introduction Nontypable Haemophilus influenzae (NTHi) is a major cause of respiratory tract disease, prompting ongoing vaccine devel...
CYP1B1 Inhibitor Chlorprothixene Increased Survival Rate of Cigarette Smoke-exposed Mice in Lethal IAV Infection 2253710
Abstract Introduction Cigarette smoke (CS) exposure increases the incidence and severity of influenza A virus (IAV) infections in humans, and...
A Novel Nanoparticle Strategy to Stimulate Regulatory CD8 T Cells Directly In Vivo for the Treatment of Multiple Sclerosis 2258793
Abstract Introduction We and others have described a regulatory CD8 T cell subset (CD8 Treg) restricted by nonclassical major histocompatibil...
Cancer Immunotherapy with IL-15Rα-armed Oncolytic Myxoma Virus Enhances Antitumor Immunity Against Solid Tumors 2260773
Abstract Introduction Immunologically cold tumors and metastatic lesions are a major therapeutic challenge due in part to tumor heterogeneity...
Targeting Novel DNase Therapeutic to Intracellular cGAS—STING Pathway for DNA Clearance in TREX1-Deficient Aicardi-Goutières Syndrome 2329186
Abstract Introduction Aicardi—Goutières syndrome (AGS) is an early onset progressive encephalopathy induced by biallelic pathogenic variants...
Investigating Th1 Cell Positioning and Cross-Regulation with IL-4 in Immune Defense 2257324
Abstract Introduction Leishmania major (L.major) is an intracellular parasite that causes cutaneous leishmaniasis, a disease in which the bal...
XTEP: A Structure-Informed Algorithm to Predict T Cell Cross-Reactivity 2267697
Abstract Introduction Each T cell is able to recognize multiple unique peptides presented on MHC molecules in a phenomenon referred to as Cro...
Single-cell blood immune cell atlas of immune diseases 2309369
Abstract Introduction Immune cells play multifaceted roles in the body, ranging from systemic and local pathogen surveillance to pathogenic a...
AXL tyrosine kinase inhibition restores anti-PD-1 efficacy in melanoma through tumor-associated macrophage—dependent mechanisms 2255689
Abstract Introduction Immune checkpoint blockade (ICB) has transformed melanoma care, yet resistance is common and often driven by tumor-asso...
Inhaled Particulate Matter Exposure Worsens the Outcome of Influenza Infection Through Direct Effects on Macrophages 2259112
Abstract Introduction Air pollution is a global health problem associated with increased morbidity and mortality from respiratory diseases, p...
Derivation of Mesenchymal Stem Cells from Induced Pluripotent Stem Cells and Their Application in Genetic Disease Modeling 2307485
Abstract Introduction Thymic stromal cells are essential for T-cell progenitor proliferation and differentiation. While thymic epithelial cel...
IP-10 Drives TCF1+ Stem-like CD8+ T Cell Depletion and Terminal Differentiation in Lupus Nephritis 2308427
Abstract Introduction Lupus nephritis (LN) is characterized by kidney damage due to immune dysregulation. CD8+ T cell dysfunction contributes...
Cell cycle-coupled transcriptional network regulates human B cell fate bifurcation 2257411
Abstract Introduction Antibody response quality and durability depend on activated B cells bifurcating into plasmablast (PB) or germinal cent...
A causal link between autoantibodies and neurological symptoms in long COVID 2309692
Abstract Introduction Acute SARS-CoV-2 infection triggers the de novo production of diverse and functional autoantibodies (AABs), even after...
Metformin fails to replicate the metabolic phenotype of Compound 991 treatment in primary human T cells 2309421
Abstract Introduction Chimeric Antigen Receptor T cell (CART) therapy, while highly effective at inducing remission in leukemia patients, onl...
Single-Cell sequencing Reveals Dynamic Intraepithelial Lymphocyte Responses to Salmonella Enteritidis Infection in Chickens 2257021
Abstract Introduction Intraepithelial lymphocytes (IELs) represent a heterogeneous population of immune cells located at the interface betwee...
Bystander activation in CD8 memory T cells is an innate program that is standalone from, yet influences TCR and TCR-driven responses 2259216
Abstract Introduction T cell receptors (TCRs) bestow CD8 memory T cells with their conventional function: highly-effective and -specific targ...
Investigating the effect of variable interferon signaling on CD4+ T cells 2307707
Abstract Introduction Inflammation guides immune responses but must be balanced: too little limits memory formation, while too much causes pa...
Lipid Nanoparticle-Encapsulated mRNA-Targeting CD19 for B and Plasma Cell Depletion in Autoimmune Diseases 2308376
Abstract Introduction Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are autoimmune diseases driven by autoreactive B cells...
Breaking The Detection Barrier With SMC® 2-Plex Immunoassays Revealing Hidden Cytokine Signatures in Autoimmune Diseases 2257825
Abstract Introduction Quantitation of blood biomarkers is critical for understanding of autoimmune diseases driven by chronic inflammatory re...
Monoclonal antibody therapy augments production of virus-specific CD4 T cells during Australian bat lyssavirus infection of the CNS 2309800
Abstract Introduction Developing therapeutic countermeasures that can target pathogens within the central nervous system (CNS) remains a chal...
B cell role in susceptibility to Pneumocystis murina infection in murine strains with a single point mutation in either IRF4 or IKZF3 2309604
Abstract Introduction B cells are typically recognized for their role in producing antibodies as part of the adaptive immune response. Howeve...