The Journal of Immunology
Articles in this Issue
GM-CSF-IRF5 Axis as a Therapeutic Target in TLR7-Mediated Macrophage Activation Syndrome 2309192
Abstract Introduction Macrophage Activation Syndrome (MAS) is a severe systemic inflammatory disorder linked to autoimmune diseases like sJIA...
Regulation of Microbial and Metabolic Balance in the Gut by B Cells 2309411
Abstract Introduction Mucosal microbes must be tightly regulated to prevent infection by opportunistic pathogens, promote commensal homeostas...
Preserving neutrophils in single cell sequencing — our experience with a multi-center cohort 2309567
Abstract Introduction Neutrophils are the most abundant innate immune cells, yet they remain underrepresented in single-cell studies because...
Sterile and Non-sterile Induction of Neuroinflammation Attenuated by Pre-habilitative Resistance Exercise 2300012
Abstract Introduction Resistance exercise (RE) has been demonstrated to improve cognition in both human and animal studies related to Alzheim...
Life-History Traits in the Context of Immunology: An Interactive Module 2310199
Abstract Introduction Eco-immunology is an interdisciplinary field that examines the immune function in ecological and evolutionary contexts....
Natural Chlamydia trachomatis Immunity Highlights CPAF as a Key Vaccine Target 2258359
Abstract Introduction Our previous studies identified Chlamydia trachomatis (CT)-specific IFNg-producing CD4+ T cells as correlates of protec...
Liver metastasis limits immunotherapy efficacy by dismantling systemic anti-tumor T cell responses through unconventional antigen presentation 2263569
Abstract Introduction Liver is a well-known site of peripheral immune tolerance induction. Because it processes antigen-rich blood from the g...
Lysophosphatidylcholine (LPC 18:2) Reprograms the Tumor Immune Microenvironment to Potentiate Immune Checkpoint Blockade 2309882
Abstract Introduction Lysophosphatidylcholine (LPC) is a bioactive lipid with emerging immunomodulatory properties, but its potential as an a...
ImmunoFoundation: A Multimodal Deep Learning Approach to Immunogenicity Prediction 2310036
Abstract Introduction Predicting immunogenicity remains a critical challenge in vaccine design, autoimmunity treatment, and pharmaceutical de...
17b-Estradiol Potentiates the Type I Interferon Signature and Pro-inflammatory Cytokine Profile in SLE via ERa Signaling 2309771
Abstract Introduction Systemic Lupus Erythematosus (SLE) is a life-threatening autoimmune disease with a profound female predominance, yet th...
The allo-antigen specificity of a T cell driving acute cellular rejection of a kidney allograft 2302494
Abstract Introduction While alloreactive CD8+ T cells are the main drivers of direct acute cellular rejection (ACR), their targets are poorly...
HLA Gene Editing of the Type I Diabetes Susceptible DQ8 Allele Inhibits Hybrid Insulin Peptide Binding and T Cell Activation 2310163
Abstract Introduction The risk for developing T1D is strongly associated with HLA-DQ8 in humans and I-Ag7 in NOD mice, both of which have an...
Xenophagocytosis blockade enhances interspecies chimerism 2258754
Abstract Introduction Organ shortage remains a major challenge in transplantation medicine. Interspecies blastocyst complementation seeks to...
Farnesol regulation of the Immune-Gut-Brain Axis in the context of CNS inflammatory demyelination 2267098
Abstract Introduction Experimental models and clinical evidence suggest multifactorial and bidirectional interactions between the gut and the...
Lymphoid Tissue-Activated Donor T cells (LADTs) for Improved Donor Lymphocyte Infusion (DLI) against Blood Cancers 2250463
Abstract Introduction Donor lymphocyte infusion (DLI) is a key strategy for treating relapses after HLA-mismatched allogeneic hematopoietic s...
Understanding unconventional T cell development to generate an ‘off the shelf’ immunotherapy to treat human diseases 2226160
Abstract Introduction Unconventional T cells represent more than 10% of total T cells within the blood and tissues of humans and play critica...
Assessment and development of computational strategies for assembling the human FCGR2/3 locus using Nanopore long-read sequencing data 2309911
Abstract Introduction The human FCGR locus encodes Fc gamma receptors (FcγRs) that mediate antibody effector functions and shape responses to...
Quantify the age-related decline of CD8+ T cell response to a novel antigen 2302770
Abstract Introduction Aging impairs T cell—mediated immunity. Mechanistically, this decline is thought to result from two major factors: (1)...
Immunomodulatory Effects of Atrazine in Human A549 Lung Epithelial Cells 2310225
Abstract Introduction The endocrine system is objectively essential for immune functioning and formation. Agents such as Atrazine (ATR) disru...
A discovery framework for IBD target discovery utilizing a tissue-derived single cell atlas 2259245
Abstract Introduction Despite advancements for Inflammatory Bowel Disease (IBD), high rates of non-response, relapse, and adverse effects und...
Tumor extracellular vesicles induce immunosuppressive myeloid cells via TIGIT/CD155 axis, dampening NLRP3-driven inflammatory response in glioblastoma 2257553
Abstract Introduction Glioblastoma (GBM), the most aggressive primary brain tumor in adults, is marked by profound immune suppression. Tumor-...
Sepsis-induced alterations to the microenvironment promotes maladaptive emergency granulopoiesis and susceptibility to Streptococcus pneumoniae 2253166
Abstract Introduction Sepsis survivors exhibit immune dysfunction and profound hematological changes that increase a patient’s risk for recur...
Metabolic checkpoint AhR prevents pathogenic B cell expansion in murine lupus 2239969
Abstract Introduction The aryl hydrocarbon receptor (AHR) integrates metabolic and immune cues, but its role in B-cell regulation during lupu...
VISTA Regulates Proinflammatory Function by Tissue Resident Peritoneal Macrophages in Response to Hemorrhagic Shock and Septic Challenge 2310024
Abstract Introduction Traumatic injury, like hemorrhagic shock, serves as an immune predisposition ‘priming’ event, where upon a secondary ch...
Rejuvenating the Aged Hematopoietic System: IL-4 Signaling Restores Lymphopoiesis and Systemic Function 2302788
Abstract Introduction Chronic inflammation and aging disrupt hematopoietic homeostasis, creating a persistent “myeloid bias” that perpetuates...