The Journal of Immunology
Articles in this Issue
Macrophage metabolic reprogramming facilitates viral entry and pyroptosis 2307659
Abstract Introduction The respiratory virus SARS-CoV-2 has posed a significant health burden since its emergence. The virus primarily infects...
A Novel Balloon Procedure for Generating Physiologically and Clinically Relevant Orthotopic Colorectal Cancer Mouse Model 2259578
Abstract Introduction The tumor microenvironment (TME) plays a crucial role in influencing therapeutic interventions in colorectal cancer (CR...
Flow Cytometric Evaluation of SYTO 9 Green Staining in Empty and Loaded Lipid Nanoparticles Using the CytoFLEX nano Flow Cytometer 2302379
Abstract Introduction Lipid nanoparticles (LNPs) have emerged as nanoscale carriers for therapeutic agents, including mRNA vaccines and gene...
Context and Stage-specific Effects of Nr4a in CD8 T cell Immunity 2309714
Abstract Introduction Poor CD8 T cell priming is a major barrier to immune control in microsatellite-stable (MSS) colorectal cancer (CRC), re...
Vectored immunotherapy sustains long-term HIV suppression after antiretroviral therapy interruption 2257591
Abstract Introduction HIV persists as a pandemic to this day, and although current antiretroviral therapies (ART) are effective, their succes...
CYLD and PP4 Coordinate TLR4 Signaling to Suppress NET Formation and Lung Injury in Sepsis 2254452
Abstract Introduction Sepsis, a leading cause of death in critical care, involves life-threatening organ dysfunction triggered by an uncontro...
Live but Stressed/damaged Tumor Cells Directly Stimulate Naïve CD8+ T cells 2309264
Abstract Introduction Immunogenic cell death (ICD) is a process where dead cells expose damage-associated molecular patterns to stimulate the...
The role of mevalonate pathway metabolites in immune homeostasis 2308615
Abstract Introduction The mevalonate pathway is a crucial metabolic pathway responsible for synthesizing key intermediates, including steroid...
Virtual memory CD8+ T cell behavior is linked to peripheralization in the lymph node 2259523
Abstract Introduction Virtual Memory (VM) CD8+ T cells constitute a distinct subset of antigen-inexperienced cells with memory-like functions...
Desmoplasia: a possible immunosuppressive microenvironment in colorectal cancer 2302078
Abstract Introduction Colorectal cancer (CRC) is the third most frequently diagnosed cancer and the leading cause of cancer-related deaths in...
CD69 Promotes Rapid Activation of Skin-Resident Memory T Cells 2309788
Abstract Introduction Tissue-Resident Memory T cells (TRMs) are long-lived antigen-specific memory T cells embedded in peripheral tissues pos...
Investigating the role of Dectin-1 in the host immune responses to Schistosoma mansoni cercariae in acute schistosomiasis 2258025
Abstract Introduction Schistosomiasis is a neglected tropical disease caused, in part, by the helminth Schistosoma mansoni, affecting over 25...
A Novel Dual-targeting PD-1 and TL1A Bispecific Antibody with Synergistic Effect for Immune Disorders Treatment 2255198
Abstract Introduction Programmed cell death protein 1 (PD-1), an inhibitory immune checkpoint on T cells, maintains immune homeostasis. Dysre...
B cells in Takayasu’s arteritis upregulate genes involved in RNA splicing, protein synthesis, and BCR signaling compared to healthy individuals 2258135
Abstract Introduction Aortic specimens from patients with large vessel vasculitis (LVV) have shown prominent B cells organizing into arterial...
Increased mTORC2 activity in naive T cells from older adults impairs asymmetric cell division 2309021
Abstract Introduction The ability of the adaptive immune system to have memory of previous pathogen encounters is the basis for vaccination a...
Antigen Presentation by Tumor Endothelium Promotes CD8+ T Cell Recruitment 2259470
Abstract Introduction The endothelium, traditionally considered a physical barrier between blood and tissues, is increasingly recognized for...
Mitigation of cerebrovascular dysfunction in dietary obesity mice via suppression neuroinflammation involving microgliosis and IL-18 2267797
Abstract Introduction Obesity is commonly associated with cerebrovascular dysfunction, but the mechanisms linking excess adiposity to impaire...
BKT300: A novel small molecule with strong anti-inflammatory and immune regulating activity 2309881
Abstract Introduction BKT300 is a novel small molecule with potent anti inflammatory and immune modulating activity. BKT300 is an inhibitor o...
Anatomic compartmentalization of a cytokine buffer system promotes anti-viral immune defense 2257966
Abstract Introduction The circulating concentration of the proinflammatory cytokine IL-6 is regulated by a blood buffer system formed by mola...
Gestational Stage—Specific Regulation of NK and T cell Compositions by Trafficking and Proliferation 2254964
Abstract Introduction Decidual natural killer (NK) and T cells undergo compositional changes during pregnancy, yet the mechanisms regulating...
Metabolic Injury Niche Suppresses Macrophage Efferocytosis and Delays Recovery in Acute Kidney Injury 2258243
Abstract Introduction Efferocytosis, the clearance of apoptotic cells by macrophages, is essential for resolving inflammation and restoring t...
Multi-omic Signatures of Vaccine Responses in Healthy Early Adolescents 2308797
Abstract Introduction Early adolescence represents a distinct phase of immune maturation between childhood and adulthood, yet this age window...
Contemplating immunology: using contemplative pedagogy practices to build critical thinking skills and confidence in data analysis and interpretation 2259675
Abstract Introduction Time is precious in immunology courses. With so much ground to cover in the span of only a few weeks, learners are expe...
Why HIV Controllers Control: Force-Stabilized TCR—pMHC Interactions Boosts Sensitivity in Elite Controllers and Protective HLA Alleles 2267511
Abstract Introduction CD8+ T cells from HIV elite controllers (ECs) have TCRs with higher antigen sensitivity than those from vaccinees (VACs...
Characterizing Import of RNA Polymerase into a Phage Nucleus 2310316
Abstract Introduction Jumbo bacteriophages in the ϕKZ-like family have shown great potential as a therapeutic to treat infections from the hu...