The Journal of Immunology
Articles in this Issue
Lag3-KIEELE domain plays a key role in Lag3-dependent Treg function 2267565
Abstract Introduction Lymphocyte activation gene 3 (Lag3) is a co-inhibitory receptor expressed on activated T cells and Foxp3+ regulatory T...
Tunable Immune Imprinting of Memory B Cells to SARS-CoV-2 Variants 2255300
Abstract Introduction Immune imprinting, historically termed “original antigenic sin”, biases memory B cell (MBC) recall toward cross-reactiv...
Investigating the Role of A2A Signaling in Caffeine-Induced EL4 T-Cell Lymphoma Growth 2258175
Abstract Introduction Adenosine A2A receptor signaling suppresses T-cell activation and promotes tumor immune evasion by dampening anti-tumor...
Nanobody-STING Agonist Reprogram the Tumor Microenvironment and Improve Adoptive Cell Therapy for Solid Tumors 2309144
Abstract Introduction Adoptive cell therapy (ACT) has demonstrated efficacy in hematologic malignancies but remains limited in solid tumors d...
Cancer-associated metabolites stimulate mucosal-associated invariant T cells for cancer cell killing 2260004
Abstract Introduction Mucosal-associated invariant T (MAIT) cells recognize microbially derived metabolite antigens presented by MHC-related...
Inborn errors of T cell topographic memory underlie organ-selective infectious diseases 2303844
Abstract Introduction Most infections are innocuous in most individuals and most infectious diseases are confined to specific organs. Inborn...
Collateral Immune Cell Signaling Compromises the Efficacy of T-cell Engaging Therapies for Cardiac Fibrosis 2327789
Abstract Introduction Cardiac fibrosis is a major driver of heart-failure progression, yet no approved therapies directly target fibrotic rem...
Lysosomal solute carriers promote pro-inflammatory signaling and MHC-II antigen presentation in dendritic cells 2303674
Abstract Introduction Mutations in lysosomal solute carrier transporters (SLCs) are associated with metabolic and inflammatory diseases. Howe...
CXCR5 Surface Marker Expression on Human Circulating Marginal Zone B cells (MZB) is Associated with Atherosclerotic Disease 2256242
Abstract Introduction Cardiovascular disease is the world’s leading killer, emphasizing the need for more effective prevention and treatment...
Type 1 conventional dendritic cell mitochondrial metabolism promotes adverse tissue remodeling after organ injury 2258277
Abstract Introduction Type 1 conventional dendritic cells [cDC1] are known for their role in antiviral and cancer immune responses, yet their...
Time Between Implantation and Electrode Array Design Inform Electrode Impedance Dynamics and Cochlear Immunity 2309163
Abstract Introduction Cochlear implantation (CI) outcomes can be limited due to immune-mediated foreign body responses. Previous research out...
Low dosage of a novel SARS-COV-2 mRNA-VLP vaccine elicits equivalent cell-mediated immunity to a licensed mRNA vaccine 2260043
Abstract Introduction mRNA-encoded virus-like particles (VLPs) are an emerging advancement in vaccine technology, enabling the self-assembly...
MAIT cells drive early hepatic fibrogenesis through a type-17 functional bias and reduced Treg cell buildup in the liver 2305794
Abstract Introduction Wound healing is a crucial process that occurs following tissue injury. While minor injuries typically resolve efficien...
Post-COVID impairment of memory T cell responses to community-acquired pathogens is associated with underlying metabolic dysfunction 2304057
Abstract Introduction Infection rates involving bacterial and viral pathogens have increased precipitously after the COVID-19 pandemic, but w...
Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III Trial 2305471
Abstract Introduction The development and deployment of mRNA vaccines during the COVID-19 pandemic was a landmark achievement in modern medic...
PI3K Delta Inhibition Alters CD8 T Cell Différentiation and Reprograms the Tumor Microenvironment Following Adoptive Immunotherapy 2247548
Abstract Introduction T cell exhaustion limits the durability of adoptive cell therapy (ACT) in solid tumors. Because PI3Kδ signaling governs...
Defining the Role of HDAC3 Enzymatic vs. Adaptor Function in T Cells 2258602
Abstract Introduction Generation of T cells requires dynamic epigenetic alteration of histones to control gene expression at each development...
Spatial colocalization of neoantigen-expressing tumor cells and cognate T cells in cancer 2309241
Abstract Introduction Tumor neoantigens have emerged as promising candidates for personalized immunotherapies, however, confirming their pres...
Investigating the Role of Interferon Signaling in the Malformation of the Down Syndrome Lung 2260174
Abstract Introduction Down Syndrome (DS) is the most prevalent chromosomal abnormality worldwide, affecting 1 in every 700 live births. Altho...
DEC-205—Targeted Antigen Delivery Enhances T Cell Immunity in a Murine Model of West Nile Virus Encephalitis 2260788
Abstract Introduction Targeted immunotherapies aimed at enhancing antiviral T cell responses are of particular interest for treating neurotro...
Characterizing Immune Cell Sexual Dimorphism in Intracranial Aneurysm via Rat IA Model and Spatial Transcriptomics 2306413
Abstract Introduction Intracranial aneurysm (IA) prevalence in the general population can be as high as 3%. Most IAs are diagnosed incidental...
GATA3 expressing CD4 T cells promote intestinal graft-versus-host disease 2306818
Abstract Introduction Hematopoietic cell transplantation (HCT) is a curative therapy for blood cancers but is complicated by graft-versus-hos...
Analysis of Langerhans Cells and CGRP-Expressing Neurons Interaction in Human Skin 2250360
Abstract Introduction Langerhans cells (LCs) are closely associated with sensory nerve fibers in the skin and express neurotransmitter recept...
Frailty-Associated Immune Aging Signatures characterized by SASP and T Cell Effector Function Profiling 2258858
Abstract Introduction Immunosenescence contributes to infection risk, poor vaccine response, and chronic inflammation in older adults. Becaus...
Elevated IgE Is Associated With Atrial Fibrillation and Promotes Cardiac Sympathetic Remodeling: A Translational Study 2309361
Abstract Introduction Mast cells reside in cardiac tissue and release inflammatory mediators upon IgE-mediated activation. While mast cells h...