The Journal of Immunology
Articles in this Issue
Skeletal muscle as an active immune niche orchestrating adaptive responses to replicon RNA vaccination 2232181
Abstract Introduction Self-amplifying replicon RNA (repRNA) vaccines formulated with the cationic nanocarrier LION™ induce strong adaptive im...
Efficacy of in-house vs. third party resources on medical student NBME style exam performance 2309816
Abstract Introduction As lecture attendance declines in medical school, many students adopt third-party educational resources as primary stud...
Clinical correlates of maternal antibody interference with oral rotavirus vaccine immunogenicity 2255869
Abstract Introduction Maternal antibodies (MatAbs) are critical for providing immune protection to neonates whilst their own immune responses...
Resveratrol-regulated genes through miRNAs in the gut epithelial cells may play an important role in the gut health and amelioration of EAE in mice 2255889
Abstract Introduction Resveratrol (RES) is an anti-inflammatory, anticancer, and antioxidant compound found abundantly in red grapes, blue be...
You want me to use AI to write a research paper !? Teaching moments with generative AI to learn about autoimmune diseases in an Immunology course 2260145
Abstract Introduction The adoption of generative AI (GAI) in higher education has the potential to transform various educational practices in...
T-bet CAR T cells: A new avenue for NSCLC therapy analyzed in lung cancer-derived organoids 2258880
Abstract Introduction Chimeric antigen receptor (CAR) T cell therapy in solid tumors is limited by the immunosuppressive tumor microenvironme...
Defining the Primary Immune Cell in the Immune Response to Coagulation Factor VIII 2245246
Abstract Introduction Hemophilia A is an X-linked bleeding disorder caused by mutations in the F8 gene, leading to a deficiency of coagulatio...
Spatial Transcriptomics Reveals Immune Remodeling in Recurrent Oligodendroglioma 2259684
Abstract Introduction Oligodendrogliomas frequently recur despite standard therapy, but how the immune microenvironment evolves during recurr...
ST8SIA4-mediated polysialylation promotes CD8+ T cell infiltration in melanoma 2246376
Abstract Introduction Immune checkpoint inhibitors (ICIs) have revolutionized melanoma treatment. However, about half of patients still face...
EQ504, a Potent AhR Modulator, Promotes Epithelial Repair and Barrier Restoration Compared to Clinically Validated AhR Agonists 2309900
Abstract Introduction The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that integrates environmental signals to...
SHMT2 Regulates T Cell Homeostasis and Mucosal Inflammation Via Metabolic and Lipid Remodeling 2256280
Abstract Introduction Serine hydroxymethyltransferase 2 (SHMT2) is a mitochondrial enzyme essential for one-carbon metabolism, nucleotide bio...
Role of Periodontitis in Inflammatory Bowel Disease 2256065
Abstract Introduction Periodontitis is a prevalent oral infection linked to the initiation/exacerbation of inflammatory bowel disease (IBD),...
ATP Mediated Mast Cell Activation is Female Dominant 2260259
Abstract Introduction Allergic diseases are more common in women than men. The explanation for this dimorphism is only partly understood. ATP...
Tissue-Resident Cytotoxic γδT Cells in Anti-tumor Immunity 2258876
Abstract Introduction Tissue-resident αβT cells are well-documented to play a critical role in controlling solid tumors. In contrast, the cha...
Clostridioides difficile-Driven Expansion of IL1B+ Monocytes Amplifies Neutrophil Recruitment in Ulcerative Colitis 2258811
Abstract Introduction Clostridioides difficile colonization, defined by PCR detection of C. difficile and Toxin B genes in fecal samples, mod...
Green-synthesized gold nanoparticles derived from Spirulina and Leptolyngbya, modulate innate immune response via M1 polarization of THP-1 macrophages 2259710
Abstract Introduction Macrophage polarization plays a pivotal role in regulating immune responses against infections and cancer. Cyanobacteri...
Staining and Characterizing Extracellular Vesicles from Platelet-Poor Plasma Using the CytoFLEX nano Flow Cytometer 2306502
Abstract Introduction Extracellular vesicles (EVs) are recognized as important mediators of intercellular communication and potential diagnos...
Regulation of gamma delta (γδ) T cell effector programming by the SLAM/SAP signaling pathway 2310142
Abstract Introduction Gamma delta (γδ) T cells are innate-like T cells that shape the developing adaptive immune response through their abili...
Bacterial toxins influence tissue resident memory T cell formation in the lungs 2256485
Abstract Introduction Tissue-resident adaptive immunity is crucial for protection against diverse respiratory pathogens. Indeed, lung-residen...
Epithelial tissue factor drives pneumococcus-mediated necrosuppurative pneumonia 2257285
Abstract Introduction Pulmonary infections induce heterogeneous lung immune responses, resulting in multiple pneumonia histopathology sub-phe...
Incoming medical students need tools to develop skills for critical thinking and become life-long learners to improve their overall performance 2260242
Abstract Introduction In the last few years, the performance of medical students on the Step 1 exam has decreased at the national level. Ther...
Processing-Optimized Multi-Epitope mRNA Vaccine Enhances HIV-1—Specific CD8+ T Cells 2258806
Abstract Introduction Despite ART, HIV-1 persists in latency and rapidly rebounds after interruption. A functional cure will require potent C...
Nanoscale artificial antigen presenting cells to expand human antigen-specific cytotoxic CD4 T cells for immunotherapy 2258982
Abstract Introduction CD4 T cells play key roles in immune modulation and cancer immunity. Increasing evidence shows they also exhibit cytoto...
EPS-3903 Is a Potent and Selective Oral STAT6 Inhibitor that Blocks Th2 Inflammation in an Ovalbumin Asthma Mouse Model 2253997
Abstract Introduction STAT6 is a key transcription factor central to type 2 inflammation and activated by interleukins IL-4 and IL-13. Inhibi...
Sex Differences in Hematological and Immunological Features of Sarcoidosis 2307192
Abstract Introduction Sarcoidosis is a systemic granulomatous disease marked by immune dysregulation. While sex-related differences in clinic...