The Journal of Immunology
Articles in this Issue
The RNA m6A reader protein YTHDF2 controls iNKT cell development and function 2308066
Abstract Introduction Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes that recognize glycolipid antigens present...
Developing a Spiral Curriculum for Immunology in Undergraduate Medical Education: Lessons from Curricular Reforms in Azerbaijan 2259347
Abstract Introduction The goal of this study, conducted at the Medical Education Department of Azerbaijan Medical University, was to improve...
Roadmap of MCPyV T-antigens for off-the-shelf therapeutic MCC vaccine development 2309574
Abstract Introduction Merkel cell carcinoma (MCC) is a rare but extremely aggressive neuroendocrine skin cancer with a two-year mortality app...
Hematopoietic origins of an early wave of CD8+ T cells 2256072
Abstract Introduction CD8+ T cells produced in early life exhibit distinct phenotypic and functional characteristics compared to those genera...
PD-L1 facilitates transcription of anti-apoptotic genes IL-8, Bcl3 and STAT1, resulting in increased proliferation of ovarian cancer cells 2247762
Abstract Introduction Blocking cell surface expression of PD-L1 has revolutionized immunotherapies, but only a subset of patients achieves du...
BCG vaccine induces distinct metabolic shifts in monocytes in vitro and peripheral blood plasma in vivo: Implications for neonatal trained immunity 2308689
Abstract Introduction BCG protects infants against tuberculosis as well as unrelated infections via incompletely understood mechanisms, inclu...
T Cells at the Maternal—Fetal Interface: Placental Dynamics in Healthy and Complicated Pregnancy 2260996
Abstract Introduction Deciphering the cellular dynamics that sustain tolerance and placental function in health and disease is essential for...
Investigating the CXCR4/CXCL12 Axis to Predict Multiple Sclerosis Symptom Onset 2259236
Abstract Introduction Radiologically Isolated Syndrome (RIS) is a pre-symptomatic form of Multiple Sclerosis (MS), where lesions are present...
Peri-Hippocampal Mast Cells Regulate Hippocampal Neurogenesis and Blood-Brain Barrier Permeability During Early Postnatal Development 2307916
Abstract Introduction Inflammation in early life is an established risk factor for the diagnosis of neurodevelopmental disorders, highlightin...
Overexpression of FGF21 in thymic stromal cells enhances T cell responses to viral infection and immune checkpoint inhibition efficacy during aging 2259870
Abstract Introduction Age-associated thymus atrophy diminishes T cell repertoire diversity, diminishing responsiveness to vaccination, viral...
Sequential plastic and terminal tolerogenic states limit helper T cell responses towards ingested antigen 2309592
Abstract Introduction T cell tolerance is the process by which the immune system is trained to ignore harmless antigens. When it breaks down,...
Complement expression in mesenchymal cells across bacterial and viral infections in the lung 2248926
Abstract Introduction We have recently identified the lung mesenchyme as a potent source of complement proteins during homeostasis. However,...
SLC15A4 Inhibition by NTX-348 Suppresses Endolysosomal Toll-like Receptor Signaling, IRF5 Activation, and Type I Interferon Induction 2249463
Abstract Introduction Recent studies have revealed that nucleic acid sensing by the endolysosomal TLRs (TLR7, TLR8, and TLR9) requires coordi...
Oral Pathogenic Bacterial Products Differently Modulate Responses in HIV+ and HIV— Peripheral Blood Immune Cells 2260611
Abstract Introduction Porphyromonas gingivalis plays key roles in the human oral microbiome and disease. Oral dysbiosis and bacterial product...
A Six-month Ketogenic Diet Alters The Immune And Metabolic Landscape In Multiple Sclerosis 2261201
Abstract Introduction A large body of preclinical research supports the immunomodulatory effects of diet, and dietary strategies for multiple...
“Listen to your nerves”: Skin Sensory Neurons promote Immunity against Parasitic Worms 2266688
Abstract Introduction Skin employs interdependent cellular networks for barrier integrity and host immunity, but most underlying mechanisms r...
Macrophage ALOX15B restricts CIITA-dependent antigen presentation via MHC II through lipid peroxide-driven NRF2 activation 2308504
Abstract Introduction Macrophage major histocompatibility complex (MHC) II-dependent antigen presentation is essential for activating CD4+ T...
Racial Disparity in Immune Response: Prospective Study in Obesity-Associated Lupus Patients 2260048
Abstract Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by systemic inflammation and the produ...
Gut bacteria-specific IgG regulates CNS neuroinflammation 2309610
Abstract Introduction The gut microbiota is an emerging regulator of neuroinflammatory diseases like Multiple Sclerosis (MS), but the mechani...
An epigenetic polarity governing T cell tolerance for commensal microbiota 2250947
Abstract Introduction T cells differentiate into subtypes to maintain immune tolerance or mount inflammatory response upon antigen stimulatio...
ATF3 Regulates Cholesterol Trafficking in Macrophages 2259886
Abstract Introduction Metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory liver disease linked to type 2 diabetes and...
Interleukin-9 Receptor Signaling Promotes an Immunosuppressive Tumor Immune Microenvironment in Oncogene-Driven Non-Small Cell Lung Cancer 2264775
Abstract Introduction Non-small cell lung cancer (NSCLC), particularly oncogene-driven subtypes, remains a leading cause of cancer-related mo...
Interferon signaling primes the lung epithelium for macrophage-mediated repair 2261178
Abstract Introduction The lung is continuously exposed to the external environment and is therefore highly susceptible to infection and injur...
Resistin-Like Molecules Modulate Lung Immunity during Influenza 2266488
Abstract Introduction Resistin-like molecules (RELMs) are cysteine-rich epithelial secreted proteins implicated in mucosal immunity. RELMα is...
High Dimensional Profiling of T cells in ME/CFS Uncovers Sex Specific Dysregulation 2309017
Abstract Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME) is a debilitating and poorly understood chronic disease. ME aff...