The Journal of Immunology
Articles in this Issue
Establishment of tissue-resident self-antigen-specific regulatory T cells protects the lung against recurrent injury 2255936
Abstract Introduction Self-reactive T cells present a threat to normal healthy tissue and are heavily regulated at steady-state by various me...
Fractalkine/CX3CL1 Functions as a Transmembrane Receptor to Promote Transendothelial Migration through glycan-dependent condensation 2257124
Abstract Introduction Biomolecular condensation provides a fundamental mechanism for organizing signaling complexes within cells. However, it...
PBMCs from people with HIV imprint diet-sensitive hepatic inflammation and lipid remodeling in NSG mice 2260261
Abstract Introduction People living with HIV (PLWH) exhibit a twofold higher risk of cardiovascular disease (CVD) compared to people without...
Intravital imaging comparison of C-kit expression and co-localization with C-kit—targeting antibody in Balb/C and humanized hIgE/hFcαRI mice 2256695
Abstract Introduction Mast cells are central regulators of immune responses and play a crucial role in allergic diseases and mastocytosis. Th...
Loss of TRIM68 in intestinal epithelial cells exacerbates colitis via TAB2 ubiquitination 2305968
Abstract Introduction Inflammatory bowel diseases (IBDs) are becoming an increasingly significant public health problem, with roughly 1 in 10...
SARS-CoV-2 vaccination protects against infection-induced autoantibody formation 2302309
Abstract Introduction SARS-CoV-2-CoV-2 infection is known to induce autoantibodies across a wide range of targets, including immune modulator...
Airway B cells regulate neutrophilic inflammation via Fas:FasL pathways during respiratory Mycoplasma infection 2255833
Abstract Introduction Neutrophils are frontline effectors in bacterial pneumonia, providing rapid phagocytosis, degranulation, and NET format...
A User-Friendly, Modality-Agnostic, Scalable Pipeline for High-Dimensional Immune Data Across Cytometry and Imaging Platforms 2310246
Abstract Introduction High-dimensional immune profiling technologies, including flow cytometry, mass cytometry, spatial proteomics, and fluor...
Investigating the Susceptibility of Peripheral Immune Cells to Human Respiratory Syncytial Virus (RSV) Infection 2256601
Abstract Introduction Respiratory syncytial virus (RSV) infects nearly all children by two years of age and causes up to 199,000 childhood de...
Spatial stochasticity in lymph node microdomains optimizes host protection and enforces self-tolerance 2257248
Abstract Introduction Regulatory T cells (Tregs) respond more strongly to self antigens than conventional T cells (Tconvs), effectively preve...
Cataloging Epitope Data: A glimpse into the manual curation efforts of the IEDB team in 2026 2309343
Abstract Introduction The Immune Epitope Database and Analysis Resource (IEDB, iedb.org) and its sibling resource, the Cancer Epitope Databas...
Therapeutic Evaluation of a C3-Targeting Small Nucleic Acid Drug in a Spontaneous Humanized C3 Glomerulopathy Mouse Model 2256845
Abstract Introduction Complement component C3 is central to the activation of the alternative pathway (AP), and its dysregulation drives C3 g...
Immunological targeting of the endogenous retroviral protein ERVMER34-1 in carcinomas promotes epitope spread and enhances response to PD-L1 blockade 2306293
Abstract Introduction Endogenous retroviruses (ERVs) are remnants of germline retroviral infections that occurred over evolution and make up...
Strain-specific variation drives CD8+ T cell activation responses 2305504
Abstract Introduction In the rapidly evolving immune system, genetic variation between individuals is a major driver of differential response...
Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol 2256825
Abstract Introduction Although macrophages are important for controlling Group A Streptococcus (GAS) infection, we and others have demonstrat...
AI/ML-Accelerated Discovery of Oral α4β7 Integrin Inhibitors for Treating Inflammatory Bowel Disease 2327698
Abstract Introduction Integrins are essential cell-adhesion receptors; α4β7 mediates gastrointestinal homing of lymphocytes via MAdCAM-1 on g...
Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis 2257113
Abstract Introduction Aging is a major risk factor for cardiovascular disease (CVD) and is linked to a functional decline of the immune syste...
Inflammation in aging and Alzheimer’s progression is marked by dysfunctional T-regulatory cell states 2257412
Abstract Introduction Aging and Alzheimer’s disease (AD) are marked by progressive brain inflammation. Microglia can become sensitized during...
Sex Differences in Platelet-Immune Responses in a Murine Model of Psychological Stress 2309588
Abstract Introduction Psychological stress is associated with systemic inflammation and platelet activation. Activated platelets serve import...
Neurotrophic receptor GFRα2 drives pro-metastatic programming of Kupffer cells in liver metastases 2257034
Abstract Introduction Gastrointestinal cancers such as colorectal and pancreatic cancers frequently metastasize to the liver, contributing si...
Enhanced Neutrophil Depletion in a Lung Tumor Model Using Recombinant IgG2c Anti-Ly6G [1A8] Antibody 2307287
Abstract Introduction Neutrophils are key modulators of tumor progression and immune responses. Ly6G-neutralizing antibodies are widely used...
Vaccine Misconceptions and Healthcare Workers 2306364
Abstract Introduction Despite vaccination being one of the most effective public-health interventions, vaccine confidence has recently declin...
Increased expression of Response Gene to Complement-32 in PBMC and kidneys of patients with lupus nephritis 2247376
Abstract Introduction We have previously shown that response gene to complement-32 (RGC-32) promoted the Th17 and Th1 dependent proinflammato...
Virus-specific CD8+ T cells in murine glioblastoma originate from brain resident and circulating memory pools and exhibit bystander activation 2259751
Abstract Introduction Tumor-infiltrating CD8+ T cells expressing tissue residency markers (CD69/CD103) correlate with positive prognosis in n...
Preexisting helminth infection alters the metabolic state of tissue resident macrophages 2257375
Abstract Introduction Majority of the infections are coinfections. Previously, we showed that herpesvirus infection in mice with preexisting...