The Journal of Immunology
Articles in this Issue
The roles of Type I interferon subtypes and signaling in mRNA lipid nanoparticle vaccine-induced CD8 T-cell protective immunity 2266569
Abstract Introduction The modification of RNA by the incorporation of N-methyl pseudo-uridine (N1mψ) renders the mRNA less inflammatory, resu...
E3 Ubiquitin Ligase Peli1 Regulates TLR7-Driven Spontaneous Germinal Center and Plasma Cell Development 2309783
Abstract Introduction TLR7 signaling is indispensable for the development of spontaneous germinal center (GC) and plasma cell (PC); however,...
Machine learning-driven stratification of Immune disorders using serum cytokine autoantibody profiles detected by cell-based multiplex flow cytometry 2259074
Abstract Introduction Impaired immune tolerance triggers aberrant or sometimes overshooting immune responses, contributing to disease manifes...
Uncovering novel regulators of immune response in rhesus macaque single-cell RNA-seq data 2260001
Abstract Introduction Single-cell RNA-seq (scRNA-seq) analyses rely on accurate gene annotations, a challenge for many species with less comp...
Type I Interferon priming in Macrophages is associated with poor responses in Patients with Advanced Prostate Cancer 2267089
Abstract Introduction Prostate cancer patients acquire resistance to standard-of-care strategies resulting in 350,000 yearly deaths. As acqui...
Kolliphor EL Alters IgE-Mediated Immune Functions 2266473
Abstract Introduction Food allergies (FA) are becoming increasingly prevalent worldwide, affecting more than 220 million people globally. Ana...
Covid19 Effects on V-ATPase Subunit Gene Expression in Ionocytes that Regulate Ion and pH Homeostasis in the Oral Cavity 2267195
Abstract Introduction Understanding innate immune responses to SARS-CoV-2 in oral minor salivary glands provides important insight into how t...
Progressive Development of Ectopic Lymphoid Structures as Mediators of Autoimmunity in a Sjögren’s Disease Mice Model 2309026
Abstract Introduction Ectopic lymphoid structures (ELS) are dynamic immune assemblies that acquire phenotypic and functional features of seco...
The Fungal Connection: Gut Mycobiome and Multiple Sclerosis 2267567
Abstract Introduction Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with unclear etiology, inf...
Immunometabolic Dichotomy Underlying Monocyte-Driven Kawasaki Disease and Lymphocyte-Driven MIS-C Pathogenesis 2309868
Abstract Introduction Kawasaki Disease (KD) and Multisystem Inflammatory Syndrome in Children (MIS-C) share overlapping clinical features but...
Structural valency of APRIL identifies and controls B cell intrinsic class switch recombination 2259580
Abstract Introduction CSR is an intrachromosomal DNA rearrangement of the IgH locus in which constant regions are replaced by another isotype...
Impact of Thymus Removal in Altering CD8 T Cell Properties 2260157
Abstract Introduction The thymus supplies naïve T cells to sustain T cell populations, but it gradually shrinks with age, leading to a declin...
Siglec15 and Siglec14 are new immune check point receptors during Mycobacterium tuberculosis infection of human macrophages 2259532
Abstract Introduction Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB) killing a million people each year. Mtb persists in macrophag...
Eosinophil Activation in the Allergic Lung Limits Pneumococcal Superinfection During Influenza 2267175
Abstract Introduction Respiratory co-infections with influenza A virus (IAV) and Streptococcus pneumoniae (Spn) drive severe morbidity and mo...
The Impact of Moringa oleifera Feed Supplementation on Circulating White Blood Cell Counts and T Lymphocyte Proliferation in Weaned Piglets 2267351
Abstract Introduction The post-weaning period for piglets is a highly challenging time. When weaned at or before 21 days, piglets do not have...
A biologically informed antibody language model framework to simulate somatic hypermutation and guide native-like antibody design 2309391
Abstract Introduction Somatic hypermutation (SHM) involves activation-induced cytidine deaminase (AID)-mediated DNA targeting, followed by er...
Acute Babesia microti Infection Is Associated With Marked Changes In The Expression Of Peripheral Blood Coding And Noncoding RNA 2301453
Abstract Introduction Babesiosis, an emerging tick-borne disease in the US caused by Babesia microti (Bm), has limited data on protective imm...
STAT4 controls pathogenicity of CD4 Th17 via IL-10 suppression 2310000
Abstract Introduction CD4 T cells, including Th17 cells (Th17), are central to the development of numerous autoimmune and chronic inflammator...
MicroRNA-1246 regulates macrophage lipid metabolism and is involved in resistance to human Mycobacterium tuberculosis infection 2259565
Abstract Introduction Resistance to Mycobacterium tuberculosis (Mtb) infection despite known exposure varies among individuals, but the molec...
Epithelial barrier function in skin-gut crosstalk in a model of food allergy 2260278
Abstract Introduction Food allergy is a worldwide public health issues that continues to grow every year. However, diagnosis is difficult, as...
Differential Expression of Immunomodulatory Markers in the Tumor Microenvironment of High-Grade Gliomas 2259573
Abstract Introduction High-grade IDH-mutant gliomas are increasingly appreciated to have distinct biology in the tumor microenvironment (TME)...
Activating Inflammation Resolution Programs Improves Immunosuppressive Therapy and Prevents Toxicity in Autoimmune Bone Marrow Failure 2267406
Abstract Introduction Chronic inflammatory and autoimmune diseases are among the leading causes of morbidity and mortality worldwide, yet imm...
Integrating in silico Humanization and DNA Delivery to engineer anti-Influenza Monoclonal Antibodies for improved in vivo expression 2267274
Abstract Introduction Highly pathogenic avian influenzas (HPAI) of the H5 subtype represent an ongoing zoonotic threat to human and animal he...
TGF-β drives uterine tissue-resident NK cell differentiation crucial for murine pregnancy 2309469
Abstract Introduction Conventional natural killer (cNK) cells differentiate in response to tissue-specific cues, generating specialized NK ce...
CX-01 Improves Survival and Attenuates Organ Failure in a Rat Polytrauma Model 2300256
Abstract Introduction Severe polytrauma can induce devastating complications, including acute kidney injury, acute respiratory distress syndr...