The Journal of Immunology
Articles in this Issue
Morning influenza vaccination elicits superior antigen-specific immune responses in adults aged 60-85 years 2256881
Abstract Introduction Increasing evidence suggests that timing of vaccine administration affects immune responses, with some studies indicati...
HLA Epitope Immunodominance and Concordant Residue Targeting Among Kidney Allograft Recipients with Antibody-Mediated Rejection 2254936
Abstract Introduction Late kidney transplant (KT) rejection is primarily caused by donor-specific antibodies (DSA) that recognize mismatched...
Exploring the Role of Natural Anti-PD-L1 antibodies in Shaping the Anti-Tumor Immune Response to Neoadjuvant Chemo-Immunotherapy in NSCLC 2308226
Abstract Introduction Non-small-cell lung cancer (NSCLC) is a major contributor to cancer-related deaths worldwide. Although the introduction...
Vessel-Associated Microglia Maintain Vascular Integrity and Prevent Early Hemorrhage in Brain Tumors 2308704
Abstract Introduction Microglia are the resident immune cells of the central nervous system, classically studied for neuroinflammation. A spe...
Development and Verification of a Novel Multiplex Immunoassay for Immune Profiling in Porcine Models 2257875
Abstract Introduction Multiplex immunoassays play a fundamental role in profiling immune-regulating proteins, including cytokines, chemokines...
Defining the contribution of breast milk immunoglobulins to infant immunity 2309834
Abstract Introduction Infants inherit far more from their mothers than just half of their genes. They also receive mitochondrial DNA, the fir...
Single Cell Insights on Inflammation-Induced Transitional States in Benign Prostate Hyperplasia 2253526
Abstract Introduction Benign prostatic hyperplasia (BPH) is an age-related prostate enlargement involving epithelial and stromal expansion. I...
DR3 Stimulation Expands Functionally Suppressive Tregs During EAU 2257177
Abstract Introduction Autoimmune uveitis (AU) is a potentially blinding ocular inflammatory disorder that can be modeled in mice (Experimenta...
Spatial transcriptome mapping to decode Cannabinoid-mediated neuroprotection in HIV-1 gp120—induced degenerating mouse brain 2255864
Abstract Introduction HIV-associated neurocognitive disorders (HAND) remain a major complication in AIDS patients and are thought to arise fr...
Gut microbiota modulation potentiates anti-tumor immunity and immunotherapy in hepatocellular carcinoma 2308568
Abstract Introduction The gut microbiota functions as a critical extrinsic regulator along the gut-liver axis, shaping hepatocarcinogenesis a...
Comparative Analysis of Nasopharyngeal Mast Cells Across Pediatric Viral Infections 2309423
Abstract Introduction Mast cells are long-lived, myeloid-lineage immune cells enriched at mucosal surfaces, where they reside to sense and re...
Neuregulin-1 Prevents RSV Induced Disruption of Human Airway Epithelium Polarity 2257854
Abstract Introduction Respiratory viruses cause significant morbidity and mortality in very young and old. Mechanism of mortality to respirat...
Diverse Microbial Exposure Enhances CD8+ T Cell Effector Memory Output and Function 2310008
Abstract Introduction Mice with normalized microbial exposure (NME) harbor an immune system that more accurately reflects that of humans comp...
Development of a sensitive and specific assay to detect the presence of immune complex in human serum 2253742
Abstract Introduction In several autoimmune diseases, such as systemic lupus erythematosus (SLE), glomerulonephritis or vasculitis, autoantib...
Effect of small molecule inhibitors of IRF3 and TBK1 signaling pathways on ovarian cancer cells 2257743
Abstract Introduction Ovarian cancer (OvCa) is a highly lethal gynecologic cancer, often due to late diagnosis and therapy resistance. High-g...
Allograft Inflammatory Factor 1 expression in cDC1 is required to direct Tbet—driven T cell immunity to defend against intracellular pathogens in vivo 2256292
Abstract Introduction Allograft Inflammatory Factor‑1 (AIF1) is a calcium‑binding protein enriched in conventional dendritic cells, with sele...
MARCO is an IFN-restricted immunometabolic decoy LPS receptor 2308885
Abstract Introduction Cytosolic sensing of bacterial lipopolysaccharide (LPS) is mediated by caspase-11 (caspase-4/5 in humans), which trigge...
Inflammatory hematopoiesis drives intestinal inflammation and is modulated by anti-TNF therapy 2309660
Abstract Introduction Chronic inflammatory diseases often originate in local tissues yet display systemic immune abnormalities, suggesting du...
QS-21 Modulates Macrophage Activation Through Synergistic Crosstalk with Pattern Recognition Receptors 2258356
Abstract Introduction QS-21, a saponin-based adjuvant, is a key component of several licensed vaccines and is commonly co-formulated with mon...
Colonic Complement Factor B Production Is Required To Respond To Tissue Injury 2310076
Abstract Introduction The complement system is an evolutionarily conserved arm of immunity. Key components of this system such as C3 and Fact...
Ketogenic diet-mediated immunometabolic regulation improves airway clearance of Klebsiella pneumoniae 2253582
Abstract Introduction Multidrug-resistant Klebsiella pneumoniae (MDR Kp) is a global health threat, causing persistent, subacute airway infec...
Mast Cell and TGF-β interactions in a model of Metabolic Dysfunction-Associated Steatotic Liver Disease and responses to cannabinoid intervention 2250623
Abstract Introduction Mast cells (MCs) are best known for their role in allergies, inflammation, and fibrosis, yet their contribution to meta...
Oral farnesol treatment of gastrointestinal inflammation models highlights the need for developing novel delivery methods 2257415
Abstract Introduction Farnesol (FOL) is a sesquiterpene alcohol produced as an intermediate of the mevalonate pathway. FOL has immunoregulato...
Persistent NK Cell Dysfunction May Be Linked to Gut Dysbiosis in HIV Despite Long-Term Antiretroviral Therapy (ART) 2308898
Abstract Introduction Natural killer (NK) cells are critical for controlling HIV and other infectious and non-infectious diseases. Although a...
Development of in vitro models to study CD137 agonist antibody mediated hepatotoxicity 2331460
Abstract Introduction Immune-mediated hepatotoxicity from biotherapeutics is a growing concern in drug development due to the poor translatab...