The Journal of Immunology
Articles in this Issue
Effect of Aptamin C on NK cell activity and cytotoxicity in vivo and in vitro: a comparison study with the effect of vitamin C 2330057
Abstract Introduction NK cells are crucial for innate immunity and rapidly target abnormal cells through ligand-receptor signaling, without p...
Investigating the Role of 7-Ketocholesterol in Alleviating Inflammatory Bowel Disease (IBD) using an Acute Mouse Model of Chemically Induced IBD 2259324
Abstract Introduction Inflammatory Bowel Disease (IBD) is an inflammatory condition involving complex interactions among the intestinal epith...
Optimization and Clinical Correlation of the Basophil Activation Test for Drug-Induced Anaphylaxis Diagnosis in Bolivia 2257595
Abstract Introduction Diagnosis of drug-induced anaphylaxis (DIA) remains challenging, especially when in vivo testing is unsafe or contraind...
IRF8 is a Key Transcriptional Regulator of IL-2—Induced NK Cell Activation and Antitumor activity 2253333
Abstract Introduction Interleukin-2 (IL-2) promotes Natural killer (NK) cell survival, proliferation, and activation; however its downstream...
Total respiratory tract immunization induces optimal systemic and regional antigen-specific immune responses 2244163
Abstract Introduction Respiratory infections represent a major global health challenge. Different intranasal vaccine strategies can target sp...
Strategic deletion of genes in BCG leads to an enhancement in immunogenicity 2267476
Abstract Introduction Tuberculosis (TB) remains one of the most pressing public health crises, attributed to the bacterium Mycobacterium tube...
Antibody-mediated CAR T Platform for Targeting Tumor Cells and the Tumor Microenvironment 2301697
Abstract Introduction CAR T cell therapy has shown success in treating hematologic malignancies but faces challenges in solid tumors due to a...
Optogenetic inhibition of inflammasome in microglia to relieve neuropathic pain 2330993
Abstract Introduction The NLRP3 inflammasome has emerged as a central hub that converts diverse cellular stress signals into IL-1β—driven neu...
IL-33-mediated Mast Cell Function is Female Dominant 2259527
Abstract Introduction Allergic asthma is more common and severe in women than in men. One component of allergic inflammation is IL-33, a cyto...
Unique features of B. burgdorferi peptidoglycan drive persistence in discrete tissues and cause responses that mimic chronic illness 2257865
Abstract Introduction Each year there are roughly 500,000 new Lyme disease cases in the United States. Lyme disease, caused by Borrelia burgd...
Structure-Guided Computational Engineering of pH-Selective B7-H3 CAR-T Cells to Mitigate On-Target/Off-Tumor Toxicity 2328499
Abstract Introduction Chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in treating hematological malignanc...
Single-Cell Multimodal Functional Glycan Profiling Identifies Novel T Cell Immunomodulatory Glycan Signatures 2309845
Abstract Introduction Glycans are key regulators of immune recognition, yet how endogenous human lectins interpret dynamic glycan changes at...
β-Catenin Stabilization Protects Against Alveolar Hemorrhage Through Amphiregulin and BATF-Mediated Regulatory T Cells 2300906
Abstract Introduction Alveolar hemorrhage (AH) is a life-threatening condition with a high mortality rate, yet the role of immune cells in it...
Messenger RNA vaccination produces functionally robust yet peripherally restricted tumor-specific cytolytic effector cells 2260948
Abstract Introduction Recent clinical trials have shown that messenger RNA vaccination against neoantigens can activate long-lasting CD8+ T c...
Regulatory T cells turn into multiple pro-inflammatory effector T cells in Mice with Atherosclerosis 2247491
Abstract Introduction Atherosclerosis is an immune-mediated disease in which regulatory T cells (Tregs) can lose lineage stability and conver...
Induction of Robust Immunity Against Hepatitis C Virus Using Rationally Adjuvanted Microneedle Patches Integrating A Secreted Form of E1E2 Heterodimer 2259568
Abstract Introduction Safe, effective, durable, and broadly deployable vaccines are needed for sustainable control of hepatitis C virus (HCV)...
Common and divergent dynamic changes of the human plasma metabolome across the first week of life in the Gambia & Papua New Guinea 2257987
Abstract Introduction The plasma metabolome changes markedly over the first week of life yet little is known regarding how these trajectories...
In silico Analysis of the Anti-Pruritic Immunomodulatory Mechanisms of Chunwangbosim-dan Components Using Network Pharmacology and Molecular Docking 2333658
Abstract Introduction Chronic pruritus is associated with chronic inflammatory skin diseases and is often non-histamine-dependent, involving...
Immune resilience after pediatric cancer treatment 2309878
Abstract Introduction Long-term survivors of pediatric cancer remain at increased risk for chronic conditions and infection-related mortality...
C-C Chemokine Receptor 7/Ligand Activation in T Cells Leads to Internalization and Recycling 2267578
Abstract Introduction CCR7 is a membrane-bound G protein-coupled receptor (GPCR), and trans-locates to membrane-bound compartments in T cells...
Immunity to influenza B and cross-reactivity to Pandemrix/pH1N1 in narcolepsy 2261229
Abstract Introduction Narcolepsy type 1 (NT1) is caused by 85-95% hypocretin (HCRT) neuron loss due to a combination of genetic and environme...
PKN1 is a Novel Therapeutic Target for the Optimal Control of GvHD 2251611
Abstract Introduction We were the first to demonstrate that targeting JAK1/2 using baricitinib (BARI) and ruxolitinib (RUX) prevents and trea...
Targeting FOXP3 Isoforms disrupts Tregs suppression in Colorectal Cancer 2259576
Abstract Introduction MSI-H colorectal cancer (CRC) displays a highly immunogenic TME. FOXP3+ Tregs are key mediators of immunosuppression wi...
UVB Phototherapy Induces a Stress-Driven Anergy Pathway as a Novel Axis of T Cell Regulation 2257995
Abstract Introduction Phototherapy is widely used to treat autoimmune diseases, yet the mechanisms underlying UVB’s immune modulation remain...
V-domain Ig suppressor of T-cell Activation (VISTA): Bone Marrow Derived Macrophage Reprogramming as Treatment for Immune Dysfunction 2335044
Abstract Introduction Acute respiratory distress syndrome (ARDS) is characterized by dysregulated inflammation leading to increased microvasc...