The Journal of Immunology
Articles in this Issue
Non-Invasive Theranostics for Endometriosis 2259283
Abstract Introduction Endometriosis (EM) presents significant clinical challenges due to associated pain, infertility, presentation and patho...
Mechanism of Gzma-Mediated GEF-H1 Activation in Intestinal Epithelial Cells Leading to Intestinal Barrier Dysfunction in Sepsis 2254641
Abstract Introduction This study investigates how Granzyme A (GZMA) induces intestinal barrier dysfunction in sepsis, specifically by activat...
Lupus Susceptibility Gene Pbx1 Regulates Treg Metabolism 2256201
Abstract Introduction The lupus susceptibility locus Sle1 includes the Pbx1 gene, which is preferentially expressed in Tregs among CD4+ T cel...
Evaluating AlphaFold 3 immune complex structure prediction and cryo-EM analysis of broadly neutralizing antibodies towards influenza hemagglutinin 2309571
Abstract Introduction Epitope:paratope interactions define the breadth and affinity an antibody has towards an antigen. Computational structu...
NKG7 is upregulated by IL-2/T-bet pathway during effector differentiation of cytotoxic CD8+ T cells 2309827
Abstract Introduction Cancer immunotherapy has transformed the treatment landscape by leveraging the immune system to eradicate malignant cel...
Development of an in vitro Sjögren’s disease tissue chip for mechanistic studies and drug screening 2300053
Abstract Introduction This project aims to develop a Sjögren’s disease (SjD) tissue chip for disease modeling and drug discovery. SjD is a ch...
IgA Dengue Virus NS1 Immune Complexes Are Associated with In Vitro Neutrophil Activation 2308886
Abstract Introduction Dengue virus (DENV) causes ∼400 million infections annually, with severe disease occurring more frequently during heter...
Intratumoral administration of a single dose of the HEPLISAV-B Vaccine and IL-15 complexes induces tumor regression in Triple Negative Brest Cancer 2259444
Abstract Introduction Triple negative breast cancer (TNBC) is a disease with limited treatment options and a poor prognosis, highlighting an...
IL-22 Depletion is a Cornerstone of Gut Immune Dysregulation in Lupus-Prone Mice 2255818
Abstract Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease that features excessive immune activation and inflammation...
Maternal fructose—induced metabolic reprogramming underlies multi-tissue inflammation and dysbiosis in HF-fed offspring: partial normalization by PCA 2256918
Abstract Introduction Excess maternal fructose intake predisposes offspring to metabolic pathology. p-Coumaric acid (PCA), a phenolic with an...
GSDME-Mediated Pyroptosis Suppresses Anti-Tumor Immunity via IL-1α—Dependent Recruitment of Immunosuppressive Myeloid Cells 2309550
Abstract Introduction Pyroptosis is widely recognized as an immunogenic form of cell death that promotes anti-tumor immunity. Gasdermin E (GS...
PROTAC-Mediated SHP2 and STAT3 Degradation as a Therapeutic Strategy for Rheumatoid Arthritis 2309941
Abstract Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, fibroblast...
Regulation of Dendritic Cell Migration by RANK Signalling in Lymphatic Endothelial Cells 2303575
Abstract Introduction Lymph nodes (LNs) are key sites for initiating adaptive immune responses, enabling antigen-specific T cells to interact...
Tim-4 Effector B Cells Express a Th17-Like Proinflammatory Cytokine Module That Is Restrained by Nur77 2266650
Abstract Introduction B cells expressing various proinflammatory cytokines potentiate immune responses in infection, autoimmunity and transpl...
FCRL1 promotes tonic PI3K/AKT signaling and constrains inducible BCR pathways 2260146
Abstract Introduction Fc receptor-like 1 (FCRL1) is an understudied B cell immunoregulatory protein with tyrosine-based signaling in humans a...
The effect of type I interferon on infection and the CD8 T cell response to Coxsackievirus B3 2255932
Abstract Introduction Coxsackievirus B3 (CVB3) is the leading cause of viral myocarditis, which disproportionately affects males in both huma...
The Evolutionary Diversification of CD300s Reveals How Gene Duplication and Structural Innovation Shift the Landscape of Immune Recognition 2257270
Abstract Introduction The CD300 gene cluster encodes activating and inhibitory lipid-binding innate immune receptors that, in humans and mice...
In vitro and In vivo Neuroinflammatory Responses to LPS in Plcg2-Deficient Mice 2259976
Abstract Introduction PLCG2, a critical immune regulator, has emerged as a key factor in Alzheimer’s disease, with genetic variants conferrin...
ImmPort: An AI Eco-System for Reproducible Immunology Research 2310238
Abstract Introduction Immunology research generates diverse molecular and clinical datasets spanning autoimmunity, infectious diseases, aller...
CMPK2 controls metabolic adaptation and GDF15 induction in inflammatory macrophages 2300489
Abstract Introduction CMPK2 is a mitochondrial monophosphate nucleotide kinase robustly induced during inflammatory macrophage activation, in...
Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP 2267451
Abstract Introduction Nanobodies have recently emerged as an alternative to classical antibodies in therapeutic and diagnostic contexts, prom...
Regulatory T cell migration and accumulation in tumors and secondary lymphoid tissue during murine 4T1 breast cancer progression 2305484
Abstract Introduction Infiltrating regulatory T cells (Tregs) within tumor microenvironments suppress tumor immune responses and are correlat...
Ptpn22 Restricts Antiviral B cell Response by Modulating BCR Signaling 2256188
Abstract Introduction B cell receptor (BCR) signal strength governs effector functions that promote viral clearance. Defining how BCR signali...
Antigen dependency defines memory and exhausted CD8 T cell fates 2257447
Abstract Introduction Antigen experienced T cell subsets are heterogenous, and can be described based on their phenotype, function, and migra...
Gestational diabetes fetal programming activates the PI3K-Akt and NETosis inflammatory axis in neonatal endothelial colony-forming cells 2259927
Abstract Introduction Gestational diabetes mellitus (GDM) is a critical model for studying the developmental programming of cardiovascular ri...