The Journal of Immunology
Articles in this Issue
Decoding the Hallmark Features of Modular CAR Domains and Their Impact on CAR T Cell Tumoricidal Activity 2305603
Abstract Introduction Engineering T cells to express a Chimeric Antigen Receptor (CAR) directs potent tumor cytotoxicity, and this cellular i...
Sex-Dependent Immune Dysregulation and Neurodevelopmental Risk in Maternal Substance Use 2266696
Abstract Introduction Maternal substance use (SU) in pregnancy is associated with adverse neurodevelopmental outcomes in offspring, with male...
Multi-omic Signatures of Baseline Immunity Shape Antiviral Responses in Adults and Infants 2327944
Abstract Introduction Infants and young children are vulnerable to influenza and exhibit prolonged viral shedding, but their “baseline” immun...
The Immune Epitope Database: Revised Receptor Data and Integration with the Adaptive Immune Receptor Repertoire Knowledge Commons 2306862
Abstract Introduction The Immune Epitope Database (IEDB, iedb.org) is a freely available resource that catalogs experimentally defined immune...
The histone demethylase KDM5C orchestrates VGLL3 and TLR7 crosstalk to drive female-biased autoimmunity 2310043
Abstract Introduction Female bias in autoimmunity is attributed in part to incomplete X chromosome inactivation of immune genes such as TLR7....
Cannabinoid Modulation of Intestinal and Neuroimmune Dysregulation in Diet-Induced Obesity 2310209
Abstract Introduction Obesity drives systemic inflammation, metabolic dysfunction, and immune dysregulation that contribute to disease. Canna...
Stem cell therapy improved nerve regeneration and functional outcomes in vascularized composite allotransplantation 2258692
Abstract Introduction Vascularized composite allotransplantation (VCA) includes limb and face transplants an emerging field to improve the qu...
35-color CytoFLEX mosaic panel profiling B cells, myeloid cells, and diagnostic markers in chronic lymphocytic leukemia (CLL) 2306495
Abstract Introduction Advances in spectral flow cytometry have enabled high-resolution analysis of immune cell diversity, particularly within...
TCR-Associated Rasal1 rewires T-cell mitochondrial metabolism to regulate checkpoint immunotherapy 2267535
Abstract Introduction Rasal1, a GTPase-activating protein, is a novel component of the T-cell receptor (TCR) complex that associates with ZAP...
All cells are immune cells: the impact of endothelial-T cell crosstalk on protective pulmonary immune responses 2333504
Abstract Introduction Not all natural infections or vaccines elicit long-lived, protective immune responses. The mechanism(s) responsible for...
Targeting glycans for cancer immunotherapy 2308347
Abstract Introduction Despite the curative potential of checkpoint blockade immunotherapy, a majority of patients remain unresponsive to exis...
Programmable regulatory T cell platform for control of neuroinflammatory diseases 2310203
Abstract Introduction Inflammation is a fundamental component of immune defense but also a major driver of pathology across autoimmune, neuro...
Multifactorial Immune Response Between Male and Female BALB/cJ and C57BL/6J Mice Exposed to Aspergillus fumigatus 2310270
Abstract Introduction Aspergillus fumigatus is an opportunistic airborne fungus that poses significant health risks, particularly to immunoco...
C5 Inhibitor Nomacopan Preserves Mitochondrial Integrity and Function in Combined Traumatic Brain Injury and Hemorrhagic Shock 2259501
Abstract Introduction Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) induce robust complement activation and systemic infla...
Myoglobin expression boosts T-cell metabolism and antitumor effector function 2306919
Abstract Introduction The tumor microenvironment is often highly hypoxic and typically suffers from a marked lack of essential nutrients, inc...
The role of interferon-stimulated gene IFIT2 in a sex-dependent Treg modulation in CNS autoimmunity 2267558
Abstract Introduction Foxp3+ regulatory T (Treg) cells are essential for maintaining immune regulation and homeostasis by preventing excessiv...
Evolution and characterization of the Fc-mediated response in bats 2331633
Abstract Introduction Bats (order Chiroptera) serve as important reservoirs of known and potentially zoonotic pathogens, driven partially by...
T-bet-deficient CD4+ T cells are sufficient for acute host resistance against Toxoplasma gondii 2308791
Abstract Introduction The transcription factor T-bet is classically considered as the master-regulator of CD4+ T cell-derived IFN-γ, which is...
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency contributes to Treg Dysfunction and Susceptibility to Systemic Lupus Erythematosus 2328440
Abstract Introduction G6PD deficiency, the most common enzymopathy worldwide, is associated with an increased risk of systemic lupus erythema...
Investigating the role of the innate immune system in releasing neutrophil extracellular traps (NETs) in response to acute Toxoplasma gondii infection 2310314
Abstract Introduction Approximately one-third of the global human population is infected with the parasite Toxoplasma gondii. The immune syst...
Cytokine-Mediated Preconditioning of Naïve CD4 T Cells Biases Subsequent Effector Differentiation 2329947
Abstract Introduction Naïve CD4 T cells are activated in secondary lymphoid organs, where integration of T cell receptor, co-stimulatory, and...
Olfr2 Regulates oxLDL Signaling and Processing, Driving a Pro-inflammatory Foamy Macrophage Phenotype 2259845
Abstract Introduction Atherosclerosis is a lipid-driven, chronic inflammation of arterial wall, characterized by plaque formation within the...
Development of strategies to visualize spatially resolved, stimulated cytokine secretion in live tissue slices 2267589
Abstract Introduction The lymph node (LN) is a spatially organized tissue where lymphocytes communicate by secreting cytokines in response to...
Differential Protein Synthesis Rates in Tregs, conventional T cells, and ex-Tregs following LPS Stimulation 2332109
Abstract Introduction Protein synthesis is a metabolically demanding process that differs among T cell subsets based on their functional stat...
High Resolution Single-Cell Epigenetic Atlas of Immune Cell Types Reveals Gene Regulatory Circuits in Healthy Humans 2308992
Abstract Introduction Single-cell chromatin accessibility (scATAC-seq) profiles genome-wide regulatory elements that shape immune cell identi...