The Journal of Immunology
Articles in this Issue
Defining Macrophage Polarization Signatures via Bioactive Recombinant Proteins and LEGENDplex™ profiling 2257843
Abstract Introduction Macrophage polarization into pro-inflammatory M1 and anti-inflammatory M2 phenotypes, including M2a (tissue repair), M2...
USP22 orchestrates an NK-suppressive program for tumor immune evasion 2309931
Abstract Introduction Over the past 17 years, our laboratory has established USP22 as a key regulator of both oncogenic and immune-evasive pr...
Lyophilized Listeria monocytogenes vaccines for storage at non-ultra-low temperatures and cancer therapy 2249461
Abstract Introduction Lyophilization (freeze-drying) is a common method of preparing bacteria for storage at higher temperatures with lyoprot...
Mapping T cell phenotype with machine learning to optimize cancer immunotherapy 2307563
Abstract Introduction T cells play a central role in adaptive immune responses, enabling vertebrates to fight infections and eliminate cancer...
Human Apolipoprotein B Specific CD8 T Cells in Atherosclerosis 2260737
Abstract Introduction Atherosclerosis, contributing to ∼one-third of global deaths, is a chronic inflammatory disorder with autoimmune featur...
Carbohydrate-Modified Virus-Like Particles as a Vaccine Platform for Leishmania braziliensis 2247392
Abstract Introduction Leishmania braziliensis is an important etiological agent of cutaneous leishmaniasis in the Americas, and it is associa...
An AAV9-Based Strategy for the Treatment of Cervical Dysplasia 2259948
Abstract Introduction Cervical cancer is the fourth most commonly diagnosed cancer in women worldwide and in some countries is the most letha...
The BMP-KLF3 circuit promotes resilient programming in CD8+ T cells during chronic infection and cancer 2257332
Abstract Introduction Cytotoxic CD8+ T cells progressively lose function and become terminally exhausted during chronic infections and cancer...
Hippo pathway coactivator WWTR1 drives self-renewal in alveolar macrophages 2257963
Abstract Introduction It is well known that Alveolar macrophages (AMs) self-renew in the lung and do not depend on circulating monocytes to m...
Novel Roles of Splice-Derived Tumor Mirtrons in the Regulation of Macrophage Dichotomy 2310054
Abstract Introduction Background: Tumor-derived exosomes play key roles in cell-cell communication within the tumor microenvironment and have...
Broad-spectrum antibiotics affect CCR4+ and CCR6+ Th17 and Treg recruitment to the gingiva 2259700
Abstract Introduction Susceptibility to periodontitis depends on the interplay between the oral plaque microbiota and host immune response. I...
Assessing Susceptibility of Cervical Explant Tissue to HIV-1 Infection Following Masculinizing Hormone Therapy 2250590
Abstract Introduction Masculinizing hormonal therapy, integral to gender-affirming care for transgender men (TGM), has immunomodulatory prope...
Enhancing Classroom Engagement through Mood Assessment of Students 2263296
Abstract Introduction Understanding and responding to students’ emotional states is becoming an increasingly important part of effective teac...
Bacteria Ammoniphilus Associated with High Tertiary Lymphoid Structures in Lung Squamous Cell Carcinoma 2248408
Abstract Introduction Non—small cell lung cancer (NSCLC) is the leading cause of cancer death, and robust biomarkers predicting prognosis and...
Spatiotemporal analysis of macrophages in neuroinflammatory lesions 2259964
Abstract Introduction During neuroinflammation such as multiple sclerosis (MS), macrophages infiltrate into the CNS and act as important driv...
Subclinical disease detection and immune profiling in siblings of patients with Enthesitis-related arthritis category of juvenile idiopathic arthritis 2257529
Abstract Introduction Enthesitis related arthritis (ERA) category of juvenile arthritis is a form of juvenile spondylarthritis. In many immun...
CD25 expressed on keratinocytes sustains CD8+ T cell homeostasis and promotes anti-tumor responses 2258211
Abstract Introduction CD8+ T cells are crucial for anti-tumor immunity, with IL-2 signaling essential for maintaining their homeostasis. Whil...
Linking multi-barrier permeability with cognitive dysfunction in Borrelia infection-associated chronic illness 2257467
Abstract Introduction Infection-Associated Chronic Illnesses (IACI), such as Post-Treatment Lyme Disease (PTLD), are a significant public hea...
High-Throughput Proteomic Profiling of Hepatocyte Response to Oncologic Compounds for Toxicity and Immune Risk Prediction in Drug Development 2259796
Abstract Introduction The clinical success of immune modulatory compounds is inevitably accompanied by new risks of toxicity. Even well estab...
Single-cell buoyant mass reveals CD8+ T-cell fitness and predicts melanoma checkpoint response 2251212
Abstract Introduction Reliable, label-free evaluations of systemic T-cell fitness are lacking. Most biomarkers are tumor-intrinsic (e.g., TMB...
MHC-II polymorphisms regulate non-cognate negative selection of CD4 T cell orchestrators of type-1 diabetes 2267361
Abstract Introduction T cell-mediated autoimmune diseases, such as type-1 diabetes (T1D), occur when breaks in tolerance mechanisms allow lym...
SCGB1D2 is a Sex-Specific Mucosal Defense that impacts Lyme Disease Susceptibility 2251807
Abstract Introduction Lyme disease is a tick-borne disease caused by bacteria of the genus Borrelia. The host factors that modulate susceptib...
T cell differentiation drives programs of resistance to PD-1-mediated inhibition 2260353
Abstract Introduction Research into basic PD-1 biology, together with the clinical picture of cancer patients treated with PD-1 blockade, con...
Monoclonal antibody therapy for rabies disease: long term impact on central nervous system recovery 2257695
Abstract Introduction Lyssaviruses are the causative agent for rabies, a disease that is uniformly fatal in humans without post-exposure prop...
The role of Glutamine metabolism in conventional Dendritic Cells and the downstream polarization of CD4+ T-cells 2258081
Abstract Introduction Allergy induced asthma is defined as a chronic disease that plagues the airways of approximately 60% all asthmatic pati...