The Journal of Immunology
Articles in this Issue
Beta-adrenergic receptors ADRB1 and ADRB2 regulate formation of memory CD8 T cells 2260268
Abstract Introduction Memory CD8 T cells persist long term in tissues and protect the body against reinfection over multiple decades. Both ly...
Polysorbate 80 Impairs Esophageal Epithelial Barrier Function: Implications for Eosinophilic Esophagitis Pathogenesis 2260115
Abstract Introduction Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease characterized by esophageal dysfunction and eosino...
A Specific Subset of Low-Density Neutrophils Aggravates Endothelial Denudation via NET-Mediated ANXA1 Sequestration: Implications for Plaque Erosion 2310364
Abstract Introduction Plaque erosion (PE) is a distinct pathological cause of acute coronary syndrome (ACS), characterized by neutrophil-medi...
Mucosal vaccination clears Clostridioides difficile colonization 2257244
Abstract Introduction Clostridioides difficile infection (CDI) is a leading cause of healthcare-associated infections in the United States. R...
Spatial IgA Plasma Cell Niches Drive Anti-Tumor Immunity in Pancreatic Cancer 2307077
Abstract Introduction Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among major cancers, with a five-year survival rate bel...
Imipridone treatment activates canonical NFkB and inflammatory signaling in THP1 differentiated macrophages 2258348
Abstract Introduction Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric high-grade glioma and is the leading cause of brain...
Proximity Proteomics Identifies IFI16 as a Host Factor of Human Coronavirus Infection 2258522
Abstract Introduction Several proteomic approaches have been employed to determine the interacting partners of SARS-CoV-2 encoded proteins, w...
Unraveling the Role of Dectin-1 in the Host Immune Response to Schistosoma mansoni Infection 2258129
Abstract Introduction Schistosomiasis is the second most prevalent parasitic disease, affecting over 250 million people worldwide. Schistosom...
Disruption of the Lung Microbiome Early in Life Protects Mice from Systemic Lupus Erythematosus 2260267
Abstract Introduction Systemic lupus erythematosus (SLE) is an incurable autoimmune disease. While the disease is well characterized, the pat...
Representation Learning on Population-Scale Proteomics to Stratify Immune Checkpoint Inhibitor Outcomes 2334712
Abstract Introduction High-throughput plasma proteomics has significant potential as a tool for monitoring immune checkpoint inhibitor (ICI)...
Regional Heterogeneity of Resident Memory CD8 T cells in the Human Brain 2259998
Abstract Introduction Resident memory T cells (TRM) reside in diverse tissues, including the central nervous system (CNS), where they provide...
The C-type lectin receptor Mincle is functionally expressed by murine bone cells and can mediate inflammatory responses to Staphylococcus aureus 2257334
Abstract Introduction It is now apparent that osteoblasts (OBs) and osteoclasts (OCs) have immune functions that play a critical role in shap...
Comparison of Bulk and Single-Cell B-Cell Receptor Sequencing Reveals Methodological Biases in Repertoire Analysis 2330649
Abstract Introduction High-throughput bulk and single-cell B cell receptor (BCR) sequencing each provide valuable insights into adaptive immu...
Characterizing C3orf52 and TSC1 as Emerging Molecular Targets in Triple-Negative and Multifocal Breast Cancer 2258409
Abstract Introduction Triple-negative and multifocal breast cancers lack effective targeted therapies and remain associated with poor clinica...
Reversible ISG15 conjugation regulates antiviral innate immunity and intracellular metabolism 2305671
Abstract Introduction ISG15 is an interferon-induced modifier that regulates diverse cellular events through protein ISGylation, a process th...
Establishing Mechanisms by which Viral Infection Exacerbates Asthma 2258608
Abstract Introduction Asthma exacerbations result in accelerated airway remodeling, increased airway obstruction, and significant loss of lun...
Non-canonical IL-2 Signalling in Treg Differentiation and Suppression 2260578
Abstract Introduction Interleukin-2 (IL-2) is indispensable for regulatory T cell (Treg) differentiation and function, signaling through the...
Pharmacological Evaluation of TSLP Dependency in Preclinical Asthma Models 2246596
Abstract Introduction Asthma is a complex life-threatening disease. Deep phenotyping of preclinical models can reveal disease-driving mechani...
Antibody affinity birth through somatic hypermutation 2260015
Abstract Introduction Developing B cells undergo V(D)J recombination, generating a B cell receptor (BCR) repertoire capable of recognizing di...
The serotonin receptor 5’HTR2c regulates alveolar macrophage responses post-helminth infection 2257539
Abstract Introduction Alveolar macrophages (AMs) are highly specialized cells that have long been recognized for their ability to regulate lu...
Viral modulation of antigen presentation: influenza A viral protein PA-X disrupts MHC I during infection 2334714
Abstract Introduction Influenza A virus can evade detection by the adaptive immune system, as evidenced by low vaccine efficacy and reinfecti...
Intestine-Resident Memory T Cells Are Differentially Controlled by TGF-β 2258442
Abstract Introduction Tissue-resident memory T cells (TRM) provide the first line of defense for the intestinal mucosa. It is well known that...
Novel FlowSOM Meta-clustering Method leveraging Insights from Cell Biology 2307173
Abstract Introduction FlowSOM is widely used for cytometry analysis due to the expansion of simultaneously detectable fluorochromes to over 4...
Expression of CD45RA on tissue resident memory T cells in the lung identifies a transcriptionally distinct population 2334756
Abstract Introduction Expression of CD45RA has been used to identify naïve T cells and a subpopulation of memory T cells which re-express CD4...
Role of ADAR1 in regulating IFN and TNF mediated responses 2260792
Abstract Introduction Immunotherapy has achieved remarkable success in hematologic malignancies, but its efficacy in solid tumors remains lim...