The Journal of Immunology
Articles in this Issue
Engineering bioluminescent bacteria for in vivo immune response tracking in D. melanogaster 2333028
Abstract Introduction Immune activation is a tightly controlled process, as overactivation leads to autoimmunity, while underactivation allow...
The multifaceted nature of digital distraction in contemporary learning environments 2256303
Abstract Introduction The rapid integration of digital technologies into daily life has transformed the educational landscape, providing unpr...
An antigen-less pro-vaccine to treat amyotrophic lateral sclerosis 2301013
Abstract Introduction Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that causes muscle paralysis and death w...
Signaling pathways via BAFF receptor/Nav1.7 channel contribute to the activation of monocytes and B cells in patients with Sjögren’s disease 2254637
Abstract Introduction We reported that the expression of a BAFF receptor, BR3, was enhanced in monocytes in patients with Sjögren’s disease (...
A Non-Invasive Dissolvable Microneedle Platform for Liposome-Encapsulated rBmHAXT(ΔCys) Delivery Against Lymphatic Filariasis 2304452
Abstract Introduction Lymphatic filariasis is a mosquito-borne neglected tropical disease-causing lymphatic dysfunction and long-term disabil...
Spatial Profiling Links Metabolic Reprogramming and Stromal Fibroblasts to PD-L1-Discordant NSCLC Responses 2309385
Abstract Introduction Understanding primary tumor features predicting post-recurrence immunotherapy response in resectable stage III non-smal...
Decoding Gut microbial immunity: How Natural Killer T cells recognise Bacteroides fragilis glycosphingolipids 2256741
Abstract Introduction The human gut microbiota comprises more than 50% of Bacteroides species that produce small diffusible molecules like sp...
Phosphatidylserine on Hypoxic Tumor-Derived sEVs Regulates ADAM17 Activity and T-Cell Fate 2310261
Abstract Introduction Tumor hypoxia is a hallmark of head and neck squamous cell carcinoma (HNSCC) and promotes tumor prgression. Tumor-deriv...
Novel autochthonous cancer model to investigate TCR signal strength in tumor-specific T cell differentiation 2334905
Abstract Introduction Immunotherapies demonstrate the potential power of CD8 T cells to eliminate cancer cells; however, these strategies onl...
Revisiting Chalk-and-Board Pedagogy in Immunology Education: A Cognitive and Visual Learning Perspective 2256289
Abstract Introduction This study examines the educational value of traditional chalk-and-board teaching in immunology courses. Despite the in...
Bisphenol-A (BPA) exposure dysregulates wound healing in larval zebrafish 2300547
Abstract Introduction Bisphenol A (BPA), a widely used component for polycarbonate plastic production, is often found in surface water and wa...
Overcoming Immunodominance by A Nanoparticle Adjuvant for Universal Influenza Vaccine Development 2255617
Abstract Introduction The immunodominance hierarchy of influenza antigens remains a major obstacle in developing broadly protective vaccines....
Phospholipid Phosphatase 6 (PLPP6) protects against influenza A virus infection in mice 2305239
Abstract Introduction Phospholipid phosphatase 6 (PLPP6) is a membrane-associated enzyme that regulates polyisoprenoid diphosphate signaling...
Identification of latanoprost as an effective vaccine adjuvant 2309626
Abstract Introduction Identifying safe and effective vaccine adjuvants remains a critical medical challenge. Finding in-clinic small molecule...
A single-nucleus atlas of skeletal muscle regeneration identifies distinct macrophage populations and their cytokine environments 2257143
Abstract Introduction Skeletal muscle possesses a remarkable capacity for regeneration, a process tightly regulated by interactions between r...
A neuronal protein fine-tunes T cell immunity in the central nervous system 2310305
Abstract Introduction CNS autoimmune diseases such as multiple sclerosis and uveitis are driven by IL-17—producing Th17 cells, whose pathogen...
Fh15 Modulates Human Neutrophil Activation and Reduces NETosis 2335416
Abstract Introduction Neutrophils are essential innate immune effectors, however, excessive activation can exacerbate inflammatory disease. A...
Antibiotic use in early life subsequently impairs MAIT-cell mediated immunity 2256328
Abstract Introduction The use of antibiotics in early life is associated with recurrent respiratory infections in children. However, the mech...
NOD1, but not NOD2, provides protection from systemic Listeria monocytogenes infection 2260383
Abstract Introduction Listeria monocytogenes (Lm) is a foodborne pathogen that can breach intestinal barriers and disseminate systemically, l...
Loss of the Y chromosome evokes extrinsic extramedullary myelopoiesis via genome-wide epigenetic reprogramming of bladder cancer tumor cells 2255981
Abstract Introduction Loss of the Y chromosome (LOY) is a prevalent chromosomal alteration occurring in a substantial proportion of male pati...
Humanized B-hIL4/hIL4RA/hTSLP/hTSLPR plus mice Model for Efficacy and Toxicity Evaluation 2302190
Abstract Introduction The IL-4 receptor (IL4RA) is a key mediator of the signaling pathways for both IL-4 and IL-13, which play pivotal roles...
High-Dose Influenza Vaccination Partially Restores Impaired T Follicular Helper Cell Function in Aging and HIV 2309758
Abstract Introduction We have previously noted that flu vaccine responses decline with aging and further impaired in people with HIV (PWH), l...
Location-directed functions of CD11c in regulating B cell tolerance 2259136
Abstract Introduction Autoimmunity, aging and infection drive aberrant accrual of CD11c+ B cells. CD11c (integrin α ITGAX), is classically de...
Manganese-Polydopamine Nano-Immunomodulator Synergistically Activates the STING Pathway and Pyroptosis for Renal Cell Carcinoma Immunotherapy 2308359
Abstract Introduction Renal cell carcinoma (RCC) remains highly resistant to conventional therapies, highlighting the need for innovative tre...
Neutrophil Activation Signature Associated with Pulmonary Fibrosis in Hermansky—Pudlak Syndrome Type 1 2308849
Abstract Introduction Hermansky—Pudlak Syndrome type 1 (HPS-1) is a rare lysosomal disorder in which all patients develop progressive pulmona...