The Journal of Immunology
Articles in this Issue
Distinct Treg subsets in human peripheral blood are defined by unique transcriptomic signatures 2252633
Abstract Introduction Regulatory CD4+ T cells (Tregs) are critical for maintaining tolerance to self. Chronic inflammation can cause Treg ins...
Immunomodulatory and neuroprotective effects of HEPPP in mice with status epilepticus 2259375
Abstract Introduction Epilepsy is a chronic neurological disorder marked by recurrent seizures caused by abnormal electrical discharges and n...
First Oral Small-molecule Inhibitors Designed by Generative AI Achieve Biologics-Like Pan-Inhibition of IL-17AA, AF, and FF Dimers 2309250
Abstract Introduction The most effective therapies for immunological diseases are injectable biologics that many patients cannot access and o...
Identification of Antigen-Specific T Cell Receptors with combinatorial peptide pooling 2259233
Abstract Introduction T cell receptor (TCR) repertoire diversity enables the orchestration of antigen-specific immune responses against the v...
Skin Immunization With ALFQ-Adjuvanted SARS-CoV-2-Spike Ferritin Nanoparticles Induces Broad and Durable Immunity in Young and Aged Mice 2259612
Abstract Introduction The development of next-generation SARS-CoV-2 vaccines with increased humoral and cellular immunogenicity and improved...
Skin mites enhance virtual memory T cell responses against immune checkpoint inhibitor-resistant tumors 2304047
Abstract Introduction Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, yet some patients remain non-responsive. The cu...
Persistent Microbial Peptidoglycan Drives Post-Infectious Autoimmunity in Lyme Disease 2265902
Abstract Introduction Persistent symptoms after infection remain a major clinical challenge, yet their immunopathogenesis is poorly understoo...
Assessing Medical Students’ Views on Using Music Parodies To Teach Immunology, As Well As The Impact of Music on Student Wellness 2257664
Abstract Introduction This study sought to determine the perspectives of medical students on the benefits of using music parodies to suppleme...
Mechanisms of mRNA lipid nanoparticle vaccines in enhancing the immunogenicity of conventional influenza and protein subunit vaccines 2253125
Abstract Introduction Lipid nanoparticles (LNP) used for mRNA vaccine delivery are known to be inflammatory at high doses. Here, we hypothesi...
Siglec-E functions as a brake for intestinal inflammation to protect from colitis-associated cancer 2260102
Abstract Introduction The lifetime risk for colorectal cancer (CRC) in the United States is approximately 4%. Individuals with Inflammatory B...
How do tissues sense proteolytic stress? 2309437
Abstract Introduction Excess proteolytic activity — from endogenous proteases, microbial toxins, venoms, and industrial enzymes — occurs duri...
High throughput CRISPR screens reveals novel roles for retroviral elements in proliferation and inflammation in murine macrophages 2259338
Abstract Introduction Ribosome Sequencing (RiboSeq) has identified translated open reading frames (ORFs) in “noncoding” elements of the trans...
Crosstalk Between Donor T Cells and Recipient IL-33+ Target Tissue Stroma Controls Alloimmune Responses Causing Graft-versus-Host Disease 2260079
Abstract Introduction Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation (AlloHCT...
Infection history and cellular origin shape long-term alveolar macrophage reprogramming 2301676
Abstract Introduction Alveolar macrophages (AMs) are essential sentinels of the lung, maintaining alveolar homeostasis through surfactant cle...
Reperfusion-Induced Low-Density Neutrophils Mediate Early Vascular Inflammation and Innate Reprogramming in Cardiac Grafts 2265648
Abstract Introduction The vascular endothelium acts as a mucosal-like barrier that regulates immune tolerance. During heart transplantation,...
Targeting NOX1 to Reprogram T Cell Activation and Metabolism for Enhanced CAR T Efficacy 2251163
Abstract Introduction T-cell exhaustion is a critical roadblock to achieving durable remission with adoptive cell therapies. The immunosuppre...
Immunology and Infection Biology in Cinema: An Interdisciplinary Undergraduate Course 2240912
Abstract Introduction Communicating the complexities of immunology and infection biology to undergraduate students, many of whom may not be s...
Oral Bacillus subtilis modulates immune responses and reduces clinical symptoms in a murine model of atopic dermatitis 2260134
Abstract Introduction Allergic diseases like atopic dermatitis (AD) have risen with modern lifestyle changes affecting the microbiome. AD inv...
Type 1 Interferon Restricts mRNA Vaccine Efficacy Through Suppression of Antigen Uptake in Conventional Dendritic Cells 2309444
Abstract Introduction mRNA-based vaccines are a versatile tool reshaping vaccinology. Therefore, it is critical to understand the underlying...
Strategy to activate ephrin-Eph signaling pathways and develop a novel therapeutic approach to regenerative wound repair in veterinary medicine 2259503
Abstract Introduction Intact skin is an essential part of innate immunity. In horses, full-thickness distal limb wounds are common and the li...
Discovery and Characterization of a Potent and Selective Oral Inhibitor of STAT6 for the Treatment of Allergic Diseases 2257118
Abstract Introduction STAT6 is a transcription factor downstream of IL-4 and IL-13 signaling that acts as a key driver of type 2 inflammation...
Yeast antigens source modulates vaccine potency and immunity mediated by CD8+ T cells in CD4+ T cell-deficient hosts 2305523
Abstract Introduction Given the global rise in fungal infections, which primarily occur in hosts with CD4+ T cell deficiency or dysfunction,...
Antibody Repertoire Modulation Alters Alzheimer’s Pathology and Behavior in the 5XFAD Mouse Model 2267871
Abstract Introduction Alzheimer’s Disease (AD) is one of the most prominent neurodegenerative diseases. The disease is associated with amyloi...
CX3CR1 Signaling Drives Tertiary Lymphoid Structure Formation and Fertility Impairment Following Treg Depletion in the Epididymis 2251411
Abstract Introduction Using an autoimmune model induced by Regulatory T cell (Treg) depletion, we found B and T cells form tertiary lymphoid...
When gut stem cells talk to the immune system: impacts on remote tumor 2240442
Abstract Introduction Pancreatic cancer is predicted to be the second leading cause of cancer deaths by 2030. Interleukin 17 (IL-17) signalin...